Master Manufacturing Services and Supply Agreement Sample Contracts

AMENDMENT NO. 1 TO MASTER MANUFACTURING SERVICES AND SUPPLY AGREEMENT
Master Manufacturing Services and Supply Agreement • February 25th, 2021 • Akebia Therapeutics, Inc. • Pharmaceutical preparations

This Amendment No. 1 to Master Manufacturing Services and Supply Agreement (“Amendment No. 1”) is made effective and entered into on December 21, 2020 (the “Amendment Effective Date”) by and between Siegfried Evionnaz SA, with principal offices located at Route du Simplon 1, 36, 1902 Evionnaz, Switzerland (together with its Affiliates and subsidiaries “Vendor”); and Keryx Biopharmaceuticals, Inc., with its offices at 245 First Street, Cambridge, Massachusetts, USA 02142 (“Keryx”).

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AMENDMENT NO. 4 TO MASTER MANUFACTURING SERVICES AND SUPPLY AGREEMENT
Master Manufacturing Services and Supply Agreement • March 1st, 2022 • Akebia Therapeutics, Inc. • Pharmaceutical preparations

This Amendment No. 4 to Master Manufacturing Services and Supply Agreement (“Amendment No. 4”) is made effective and entered into on December 17, 2021 (the “Amendment Effective Date”) by and between Siegfried Evionnaz SA, with principal offices located at Route du Simplon 1, 36, 1902 Evionnaz, Switzerland (together with its Affiliates and subsidiaries “Vendor”); and Keryx Biopharmaceuticals, Inc., with its offices at 245 First Street, Cambridge, Massachusetts, USA 02142 (“Keryx”).

MASTER MANUFACTURING SERVICES AND SUPPLY AGREEMENT
Master Manufacturing Services and Supply Agreement • February 21st, 2018 • Keryx Biopharmaceuticals Inc • Pharmaceutical preparations

This Master Manufacturing Services and Supply Agreement (this “Agreement”) is entered into as of the date of last signature (the “Agreement Date”), by and between Siegfried Evionnaz SA (together with its Affiliates and subsidiaries, “Vendor”), with principal offices located at Route du Simplon 1, 36, 1902 Evionnaz, Switzerland, and Keryx Biopharmaceuticals, Inc. (together with its Affiliates and subsidiaries, “Keryx”), with principal offices located at One Marina Park Drive, 12th Floor, Boston, MA 02210, USA.

AMENDMENT NO. 2 TO MASTER MANUFACTURING SERVICES AND SUPPLY AGREEMENT
Master Manufacturing Services and Supply Agreement • February 25th, 2021 • Akebia Therapeutics, Inc. • Pharmaceutical preparations

This Amendment No. 2 to Master Manufacturing Services and Supply Agreement (“Amendment No. 2”) is made effective and entered into on January 29, 2021 (the “Amendment Effective Date”) by and between Siegfried Evionnaz SA, with principal offices located at Route du Simplon 1, 36, 1902 Evionnaz, Switzerland (together with its Affiliates and subsidiaries “Vendor”); and Keryx Biopharmaceuticals, Inc., with its offices at 245 First Street, Cambridge, Massachusetts, USA 02142 (“Keryx”).

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