License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of LeidenRegulation of Immune Responses in Atherosclerosis • March 28th, 2013
Objective: Restoration of immune homeostasis in atherosclerosis represents the ultimate goal of an immune-based therapy. Myeloid-derived suppressor cells (MDSCs) are a population of immature myeloid cells that potently suppress immune responses in various pathological settings, via multiple mechanisms, including inhibition of T cell responses. They express the myeloid markers CD11b and Gr-1 and can be subdivided in monocytic-MDSCs, expressing high levels of Ly6C, or granulocytic-MDSCs, which are Ly6G positive. In the present study, we determined the role of MDSCs in atherosclerosis by an adoptive transfer of CD11b+Gr-1+ cells into LDLr-/- mice fed a Western-type diet.
