Research and Development Agreement & License Sample Contracts

RITTER PHARMACEUTICALS, INC. AMENDMENT NO. 1 TO RESEARCH AND DEVELOPMENT AGREEMENT & LICENSE
Research and Development Agreement & License • March 23rd, 2015 • Ritter Pharmaceuticals Inc • Pharmaceutical preparations • Hawaii

This Amendment No. 1 (the “Amendment”) to the Research and Development Agreement & License, dated as of November 17, 2010 (the “Original Agreement”), is made and entered into as of July 6, 2011, pursuant to Section 13.4 of the Original Agreement, by and among KOLU POHAKU TECHNOLOGIES, LLC, a Delaware limited liability company (together with its successors and assigns, “Kolu Pohaku”); KOLU POHAKU MANAGEMENT, LLC, a Delaware limited liability company (together with its successors and assigns, “KPM”); and RITTER PHARMACEUTICALS, INC., a Delaware corporation (together with its successors and assigns, the “Company”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the respective meanings assigned to them in the Original Agreement.

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RITTER PHARMACEUTICALS, INC. AMENDMENT NO. 3 TO RESEARCH AND DEVELOPMENT AGREEMENT & LICENSE
Research and Development Agreement & License • March 23rd, 2015 • Ritter Pharmaceuticals Inc • Pharmaceutical preparations • Hawaii

This Amendment No. 3 (the “Amendment”) to the Research and Development Agreement & License, dated as of November 17, 2010, and amended on Tidy 6, 2011, and September 30, 2011 (as amended to date, the “Original Agreement”), is made and entered into as of February 6, 2012, pursuant to Section 13.4 of the Original Agreement, by and among KOLU POHAKU TECHNOLOGIES, LLC, a Delaware limited liability company (together with its successors and assigns, “Kolu Pohaku”); KOLU POHAKU MANAGEMENT, LLC, a Delaware limited liability company (together • with its successors and assigns, “KPM”); and RITTER PHARMACEUTICALS, INC., a Delaware corporation (together with its successors and assigns, the “Company”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the respective meanings assigned to them in the Original Agreement.

RITTER PHARMACEUTICALS, INC. AMENDMENT NO. 2 TO RESEARCH AND DEVELOPMENT AGREEMENT & LICENSE
Research and Development Agreement & License • March 23rd, 2015 • Ritter Pharmaceuticals Inc • Pharmaceutical preparations • Hawaii

This Amendment No. 2 (the “Amendment”) to the Research and Development Agreement & License, dated as of November 17, 2010, and first amended on July 6, 2011 (as amended to date, the “Original Agreement”), is made and entered into as of September 30, 2011, pursuant to Section 13.4 of the Original Agreement, by and among KOLU POHAKU TECHNOLOGIES, LLC, a Delaware limited liability company (together with its successors and assigns, “Kolu Pohaku”); KOLU POHAKU MANAGEMENT, LLC, a Delaware limited liability company (together with its successors and assigns, “KPM”); and RITTER PHARMACEUTICALS, INC., a Delaware corporation (together with its successors and assigns, the “Company”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the respective meanings assigned to them in the Original Agreement.

RITTER PHARMACEUTICALS, INC. AMENDMENT NO. 4 TO RESEARCH AND DEVELOPMENT AGREEMENT & LICENSE
Research and Development Agreement & License • March 23rd, 2015 • Ritter Pharmaceuticals Inc • Pharmaceutical preparations • Hawaii

This Amendment No. 4 (the “Amendment”) to the Research and Development Agreement & License, dated as of November 17, 2010, and amended on July 6, 2011, September 30, 2011 and February 6, 2012 (as amended to date, the “Original Agreement”), is made and entered into as of November 4, 2013, pursuant to Section 13.4 of the Original Agreement, by and among KOLU POHAKU TECHNOLOGIES, LLC, a Delaware limited liability company (together with its successors and assigns, “Kolu Pohaku”); KOLU POHAKU MANAGEMENT, LLC, a Delaware limited liability company (together with its successors and assigns, “KPM”); and RITTER PHARMACEUTICALS, INC., a Delaware corporation (together with its successors and assigns., the “Company”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the respective meanings assigned to them in the Original. Agreement.

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