Secured Non-Revolving Sample Contracts

SECURED NON-REVOLVING TIME NOTE
Secured Non-Revolving • March 1st, 2004 • Curis Inc • Biological products, (no disgnostic substances)

Unless the entire principal balance hereunder is converted to a term note in accordance with the Agreement for value received, on January 20, 2005, the undersigned, Curis, Inc. (the “Borrower”) promises to pay to Boston Private Bank & Trust Company (the “Bank”), or order, the principal sum of One Million Two Hundred Fifty Thousand ($1,250,000.00) Dollars, or if less, such amount as may be the aggregate unpaid principal amount of all Advances made by the Bank to the Borrower pursuant to a Line of Credit Agreement for the Acquisition of Equipment and Leasehold Improvements between the Borrower and the Bank of even date (the “Agreement”), together with interest (as provided below) on the aggregate unpaid principal balance from time to time outstanding on the first day of each calendar month, commencing on the first day of the first month next succeeding the date hereof, at a fluctuating interest rate per annum equal to the Bank’s Base Rate in effect from time to time plus one (1.0%) perce

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SECURED NON-REVOLVING TIME NOTE
Secured Non-Revolving • March 15th, 2005 • Curis Inc • Biological products, (no disgnostic substances)

Unless the entire principal balance hereunder is converted to a term note in accordance with the Agreement for value received, on February 28, 2005, the undersigned, Curis, Inc. (the “Borrower”) promises to pay to Boston Private Bank & Trust Company (the “Bank”), or order, the principal sum of Two Million Two Hundred Fifty Thousand ($2,250,000.00) Dollars, or if less, such amount as may be the aggregate unpaid principal amount of all Advances made by the Bank to the Borrower pursuant to a Line of Credit Agreement for the Acquisition of Equipment and Leasehold Improvements between the Borrower and the Bank of even date (the “Agreement”), together with interest (as provided below) on the aggregate unpaid principal balance from time to time outstanding on the first day of each calendar month, commencing on the first day of the first month next succeeding the date hereof, at a fluctuating interest rate per annum equal to the Bank’s Base Rate in effect from time to time plus one (1.0%) perc

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