Exhibit 10.4 RIBOZYME PHARMACEUTICALS, INC. 2950 Wilderness Place Boulder, Colorado 80301 February 11, 2003 Elan International Services, Ltd. Clarendon House 2 Church St. Hamilton, Bermuda Attn: Boards of Directors Re: Securities Purchase Agreement,...Securities Purchase Agreement, License Agreements and Subscription, Joint Development and Operating Agreement • February 14th, 2003 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
