Supplement to Guarantee Sample Contracts

Contract
Supplement to Guarantee • September 11th, 2017 • PRA Health Sciences, Inc. • Services-commercial physical & biological research

SUPPLEMENT NO. 1 dated as of September 6, 2017 (this “Supplement”) to the Guarantee dated as of December 6, 2016, among each of the Guarantors listed on the signature pages thereto and any other entity that becomes a party thereto pursuant to Section 20 thereof (each such entity individually, a “Guarantor” and, collectively, the “Guarantors”), and Wells Fargo Bank, National Association, as Collateral Agent for the Secured Parties (the “Guarantee”).

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