EXHIBIT 10.46 CONFIDENTIAL PORTIONS HAVE BEEN OMITTED BASED UPON A REQUEST FOR CONFIDENTIAL TREATMENT PURSUANT TO RULE 24b-2 OF THE SECURITIES EXCHANGE ACT OF 1934 AND HAVE BEEN SEPARATELY FILED WITH THE COMMISSION. AMENDMENT TO TIMOLOL AGREEMENT This...Timolol Agreement • April 30th, 2003 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances
