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XXXXXXXXXXXX XXXXX • September 20th, 2016

Amendment No. 1 to Contract on Clinical Trial concluded on 26. 11. 2014 by and between F. Hoffmann-La Roche Ltd, having a place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland represented by Quintiles Czech Republic s.r.o., having a place of business at Radlická 714/113a, 158 00 Praha 5, Czech Republic (Hereinafter referred to as the ‘Sponsor’) and Contractual research organization Quintiles Czech Republic, s.r.o., having a place of business at Radlická 714/113a, 158 00 Praha 5, Czech Republic, Identification number: 247 68 651, Tax Identification number: CZ247 68 651 (Hereinafter referred to as the ‘Contractual research organization’) and Krajská nemocnice T. Bati, a. s., having a place of business at Havlíčkovo nábřeží 600, 762 75 Zlín, Czech Republic, Identification number: 276 61 989, Tax identification number: CZ27661989, represented by Ing. Pavel Calábek, Chairman of the Board of Directors and MUDr. Marcel Guřan, Member of the Board of Directors, reg

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