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COM503 definition

COM503 means the Antibody with the heavy chain and light chain protein sequences described in Schedule 1.51 (COM503) and with the internal CGEN identifier COM503.
Sample 1

Examples of COM503 in a sentence

  • COM503 is a potential first-in-class, high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby releasing natural IL-18 in the tumor microenvironment and inhibiting cancer growth.

  • Reasonably in advance of the IND filing for COM503, the Parties shall discuss and agree to the initial Clinical Trial protocol for the COM503 Phase 1 Trial (the “COM503 Phase 1 Trial Protocol”).

  • Within [**] after the Effective Date, CGEN and Gilead will start working together to commence the transfer to Gilead (or its designee) all IL-18 Know-How that is necessary or reasonably useful to enable the Manufacture of COM503, [**], and [**] (including [**]) (a “Manufacturing Technology Transfer”).

  • The COM503 Phase 1 Trial includes the COM503 Phase 1a Trial and COM503 Phase 1b Trial.

  • Within [**] after the COM503 Phase 1 Trial Completion, CGEN shall deliver to Gilead [**] from the COM503 Phase 1 Trial.

  • Gilead shall have the sole right and control over the Manufacture, either by itself or through one or more Third Parties, of any COM503 for Commercialization activities conducted by or on behalf of Gilead in the Field in the Territory.

  • During the Development Term, CGEN is responsible, at its sole cost and expense (subject to Section 10.1(e) (Early Development Program Transfer Costs)), for the Manufacture, either by itself or through its Permitted Subcontractors, of, and shall provide, all amounts of IL-18 Product necessary to undertake the Development activities conducted by or on behalf of the Parties under the Development Plan (including, for clarity, the COM503 Phase 1 Trial), including [**].

  • In addition, the Company’s therapeutic pipeline of early-stage immuno-oncology programs consists of programs aiming to address various mechanisms of immune resistance, of which the most advanced program, in IND enabling studies is COM503, which is licensed to Gilead.COM503 is a potential first-in-class, high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby freeing natural IL-18 in the tumor microenvironment to inhibit cancer growth.

  • Any proposed amendments to the Development Plan or the COM503 Phase 1 Trial Protocol will become effective only upon [**] and [**], including under Section 4.1(d) (Decision-Making) to the extent applicable.

  • CGEN uses a CMO for the Manufacture of COM503 engaged under the CGEN CMO Manufacturing Agreement(s).

Related to COM503

  • 03 Regulation S Global Notes"................................. 2.01 "Representative"............................................ 11.03 "Resale Restriction Termination Date"....................... 2.15 "U.S. Global Notes"......................................... 2.01

  • ESFA means the Education and Skills Funding Agency.

  • Sxxxxxxx-Xxxxx Act means the Sxxxxxxx-Xxxxx Act of 2002, as amended.

  • Xxxx-Xxxxx-Xxxxxx Act means the Xxxx-Xxxxx-Xxxxxx Antitrust Improvements Act of 1976, as amended.

  • Xxxx-Xxxxx Act means the Xxxx-Xxxxx Xxxx Street Reform and Consumer Protection Act.

  • Xxxxxxxx-Xxxxx Act means the Xxxxxxxx-Xxxxx Act of 2002.

  • Xxxxx–Xxxxx Act For any federally assisted construction contract, in excess of two thousand dollars ($2,000), the contractor, subcontractor, subrecipient shall comply with all of the requirements of the Xxxxx-Xxxxx Act (40 U.S.C. 3141 – 3148) as supplemented by Department of Labor Regulations (29 CFR Part 5, “Labor Standards Provisions Applicable to Contracts Covering Federally Financed and assisted Construction”); and the Xxxxxxxx “Anti-Kickback” Act (40 U.S.C. 3145), as supplemented by Department of Labor regulations (29 CFR Part 3, “Contractors and Subcontractors on Public Building or Public Work Financed in Whole or in Part by Loans or Grants from the United States”).

  • Notification Email Address means the email address (if any) designated by Customer, via the user interface of the Processor Services or such other means provided by Google, to receive certain notifications from Google relating to these Data Processing Terms.

  • NI 51-102 means National Instrument 51-102 – Continuous Disclosure Obligations;

  • Van Xxxxxx Xxxrican Capital Tax Free High Income Fund ("Tax Free High Income Fund") Van Xxxxxx Xxxrican Capital California Insured Tax Free Fund ("California Insured Tax Free Fund") Van Xxxxxx Xxxrican Capital Municipal Income Fund ("Municipal Income Fund") Van Xxxxxx Xxxrican Capital Intermediate Term Municipal Income Fund (Intermediate Term Municipal Income Fund") Van Xxxxxx Xxxrican Capital Florida Insured Tax Free Income Fund ("Florida Insured Tax Free Income Fund") Van Xxxxxx Xxxrican Capital New Jersey Tax Free Income Fund ("New Jersey Tax Free Income Fund") Van Xxxxxx Xxxrican Capital New York Tax Free Income Fund ("New York Tax Free Income Fund") Van Xxxxxx Xxxrican Capital California Tax Free Income Fund ("California Tax Free Income Fund") Van Xxxxxx Xxxrican Capital Michigan Tax Free Income Fund ("Michigan Tax Free Income Fund") Van Xxxxxx Xxxrican Capital Missouri Tax Free Income Fund ("Missouri Tax Free Income Fund") Van Xxxxxx Xxxrican Capital Ohio Tax Free Income Fund ("Ohio Tax Free Income Fund")

  • NI 44-102 means National Instrument 44-102 – Shelf Distributions;

  • Master Street Address Guide or "MSAG" is a database of street names and house number ranges within their associated communities defining particular geographic areas and their associated ESNs to enable proper routing of 911 calls. "Meet Point" is a point of Interconnection between two (2) networks, designated by two (2) Telecommunications Carriers, at which one Carrier's responsibility for service begins and the other Carrier's responsibility ends.

  • 01 Change of Control Offer"..................................................... 4.08 "covenant defeasance option".................................................. 8.01(b) "Custodian"................................................................... 6.01 "Definitive Securities"....................................................... Appendix A "Event of Default"............................................................ 6.01 "Excess Proceeds"............................................................. 4.06 "Exchange Securities"......................................................... Preamble "Global Securities"........................................................... Appendix A "Guaranteed Obligations"...................................................... 10.01 "incorporated provision"...................................................... 11.01 "Initial Securities".......................................................... Preamble "legal defeasance option"..................................................... 8.01(b) "Notice of Default"........................................................... 6.01 "Offer Period"................................................................ 4.06(d) "Original Securities"......................................................... Preamble "Paying Agent"................................................................ 2.04 "protected purchaser"......................................................... 2.08 "Refinancing Indebtedness".................................................... 4.03(b) "Refunding Capital Stock"..................................................... 4.04 "Registration Agreement"...................................................... Appendix A "Registered Exchange Offer"................................................... Appendix A "Registrar"................................................................... 2.04 "Restricted Payment".......................................................... 4.04(a) "Retired Capital Stock"....................................................... 4.04(b) "Securities Custodian"........................................................ Appendix A "Shelf Registration Statement"................................................ Appendix A "Special Redemption".......................................................... 3.07(b) "Special Redemption Date"..................................................... 3.07(b) "Special Redemption Price".................................................... 3.07(b) "Successor Company"........................................................... 5.01(a) "Successor Guarantor"......................................................... 5.01(b)(i) "TRW Automotive Luxembourg"................................................... 4.11(d)

  • NI 45-102 means National Instrument 45-102 – Resale of Securities;

  • Post Office Box means each post office box to which Obligors are directed to mail payments in respect of the Pledged Loans.

  • O. Reg. 419/05 means the Ontario Regulation 419/05, Air Pollution – Local Air Quality.

  • 15(519) means the weekly statistical release designated as such, or any successor publication, published by the Board of Governors of the Federal Reserve System. The date of determination of a Make-Whole Premium will be the third Business Day prior to the applicable prepayment date and the "most recent H.15(519)" means the H.15(519) published prior to the close of business on the third Business Day prior to the applicable prepayment date.

  • LOCKHEED XXXXXX means LOCKHEED XXXXXX CORPORATION, acting through its companies or business units as identified on the face of this Contract. If a subsidiary or affiliate of LOCKHEED XXXXXX CORPORATION is identified on the face of this Contract, then "LOCKHEED XXXXXX" means that subsidiary or affiliate.

  • X.X. Xxxxxx shall have the meaning set forth in the preamble.

  • Cathodic protection tester means a person who can demonstrate an understanding of the principles and measurements of all common types of cathodic protection systems as applied to buried or submerged metal piping and tank systems. At a minimum, such persons must have education and experience in soil resistivity, stray current, structure-to-soil potential, and component electrical isolation measurements of buried metal piping and tank systems.

  • Xxx Xxxxxxx “Xxxxx Xxxxxxx” “Xxxxx Xxxxx”

  • Xxx Xxxxxx Xxxx Xxxxx” ”Xxxxx Xxxxxxx” ”Xxxxx Xxxxxxxx” ”Xxxxxxxxx Xxxxxxx” ”Xxxxx Xxxxxx”

  • NI 81-102 means National Instrument 81-102 – Investment Funds.

  • Xxxxxxx Act means the Xxxxxxx Antitrust Act of 1890, as amended, and the rules and regulations promulgated thereunder.

  • XX Xxxxx “Xxx Xxxxxxx”

  • Xxx Xxxxxxxx “Xxxx Xxxxxxx”

Most Referenced Clauses

Most Referenced Definitions