Examples of ISIS 14803 in a sentence
In preclinical studies, ISIS 14803 demonstrated specific reduction of the HCV RNA expression in both cell cultures and mouse model systems.
As noted in Section 2, some of our datasets include only women (e.g., the National Longitudinal Surveys of Mature or Younger Women) or only men (the Occupational Changes in a Generation datasets), so a possible concern is that the differences in mobility by sex are an artifact of using different datasets.
Upon binding to the complementary target sequence, ISIS 14803 inhibits expression of HCV proteins required for viral replication.
The ability of ISIS 14803 to inhibit HCV gene expression in cell culture and in a novel in vivo mouse model of HCV gene expression demonstrates the potential of this compound as a drug development candidate.
ISIS 14803 our antisense inhibitor of HCV, ISIS 14803, may represent a significant therapeutic advance in treating this serious viral epidemic.
Patients in this Phase I/II trial will receive ISIS 14803 intravenously 3 times a week for 4 weeks.
ISIS 14803 is an antisense inhibitor of the Hepatitis C Virus that is in Phase I/II clinical trials in patients with chronic Hepatitis C.
Studies of the subcutaneous delivery of ISIS 14803 are also planned.
In conjunction with its continuing restructuring efforts, Elan concluded its participation in the HepaSense collaboration in 2002 and the Company reacquired all rights to ISIS 14803, the compound that the collaboration had been developing.
Subsequently, studies of ISIS 14803 using Elan's MEDIPAD, a minimally invasive microinfusion pump, will be initiated.