Lowest observed adverse effect level definition

Lowest observed adverse effect level or "LOAEL" means the lowest tested dose or concentration of a substance that resulted in an observed adverse effect in exposed test organisms when all higher doses or concentrations resulted in the same or more severe effects.
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Lowest observed adverse effect level or “LOAEL” means the lowest concentration of a hazardous substance at which there is a statistically or biologically significant increase in the frequency or severity of an adverse effect between an exposed population and a control group.
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Lowest observed adverse effect level or "LOAEL" means the low- est concentration of a hazardous substance at which there is a statis- tically or biologically significant increase in the frequency or se- verity of an adverse effect between an exposed population and a con- trol group.
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Examples of Lowest observed adverse effect level in a sentence

  • The Observed Effect Levels are as follows: Significant observed adverse effect level: This is the level of noise exposure above which significant adverse effects on health and quality of life occur; Lowest observed adverse effect level: this is the level of noise exposure above which adverse effects on health and quality of life can be detected; and No observed effect level: this is the level of noise exposure below which no effect at all on health or quality of life can be detected.

  • A clinical test for detecting lead in living humans LOAEL Lowest observed adverse effect level.

  • Summarised toxic risk values for fluoride (Source: TERA (toxicology excellence for risk assessment)) Organization NameAgency for Toxic Substances Disease registry (ATSDR) **NOAEL = No observed adverse effect level; *LOAEL = Lowest observed adverse effect level.

  • Repeated dose toxicity - Lowest observed adverse effect level - 300 mg/kg Rat - male + female(ECHA) liver - Practical/human experience.

  • Margin of Exposure; NOAEL = No observed adverse effect level; and LOAEL = Lowest observed adverse effect level.

  • The Observed Effect Levels are as follows: ▲ Significant observed adverse effect level: This is the level of noise exposure above which significant adverse effects on health and quality of life occur; ▲ Lowest observed adverse effect level: This is the level of noise exposure above which adverse effects on health and quality of life can be detected; and ▲ No observed effect level: This is the level of noise exposure below which no effect at all on health or quality of life can be detected.

  • Lowest observed adverse effect level (LOAEL) and no observed adverse effect level (NOAEL) have been identified in animal experiments for only a few substancesFurther, well-controlled laboratory animal studies published in the peer-reviewed scientific literature are insufficient alone to inform mechanisms relevant to human workplace exposures.

  • The ADI concept has often been used as a tool in reaching risk management decisions with an equation as follows: Acceptable Daily Intake (ADI) = NOAEL (or LOAEL)/(UF*MF) (Eq. 1) NOAEL = No observed adverse effect level LOAEL = Lowest observed adverse effect level UF = uncertainty factor MF = modifying factor In this equation the NOAELs (or LOAELs) that are derived directly from toxicological studies, may be modified by both an UF and MF.

  • Noise levels measured from enclosed outdoor private amenity areas (gardens) should attain the 50dB(A) desirable criteria (Considered by Worcestershire Regulatory Services (WRS) to be the Lowest observed adverse effect level (LOAEL) and not exceed the upper limit recommended within BS8233:2014 being 55dB(A) (Considered by WRS to be the Significant Observed Adverse Effect Level (SOAEL)**.

  • In other words, it is the tested dose that directly precedes the LOAEL.9 Lowest observed adverse effect level: minimum dose leading to an observed harmful effect.


More Definitions of Lowest observed adverse effect level

Lowest observed adverse effect level or "LOAEL" means the lowest tested dose or concentration of a substance which results in an observed
Sample 1
Lowest observed adverse effect level or "LOAEL" means the lowest concentration of a hazardous substance at which there is a statis- tically or biologically significant increase in the
Sample 1Sample 2
Lowest observed adverse effect level or "LOAEL" means the low- est concentration of a hazardous substance at which there is a statis-
Sample 1

Related to Lowest observed adverse effect level

  • Material Adverse Effect shall have the meaning assigned to such term in Section 3.1(b).

  • Material Adverse Change means any material adverse change in the business, condition (financial or otherwise), operations, performance, properties or prospects of the Borrower or the Borrower and its Subsidiaries taken as a whole.

  • Highest-level owner means the entity that owns or controls an immediate owner of the offeror, or that owns or controls one or more entities that control an immediate owner of the offeror. No entity owns or exercises control of the highest level owner.