No observable adverse effect level definition

No observable adverse effect level or "NOAEL" means the highest tested concentration that did not cause a statistically significant occurrence of an adverse effect in comparison with a control when no lower test concentration caused an injurious or adverse effect.
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No observable adverse effect level or "NOAEL" means the highest exposure level at which there is no statistically or biologically significant increase in the frequency or severity of adverse effects between the exposed population and its appropriate control group.
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Examples of No observable adverse effect level in a sentence

  • No observable adverse effect level (NOAEL) was recorded in rats when a single dose of 126 X 106 cells/kg body weight (10 X TD) Stempeucel – CLI™ was administered.

  • The higher vulnerability of these groups is expressed by the lower No observable adverse effect level (NOAEL).

  • We believe that the results obtained fully agree with the mechanism.In histological study the polymeric ester has one exposure level, NOEL (No observable adverse effect level) the high dose that did not cause any clinical adverse effect.

  • Publications are vital for the execution of the maintenance program.

  • These relate to hazard characterization, describing the dose-response relationship and the derivation of an estimate of a Point of Departure (PoD) such as the Benchmark Dose (BMD) or a No observable adverse effect level (NOAEL) which can then be used to establish „safe‟ human exposure.

Related to No observable adverse effect level

  • Partnership Material Adverse Effect means any change, circumstance, effect or condition that is, or could reasonably be expected to be, materially adverse to the business, financial condition, assets, liabilities or results of operations of the Partnership Group, taken as a whole.

  • Company Material Adverse Effect means any (x) termination of the Commercial Supply Agreement, dated as of October 9, 2013, by and between the Company and LTS Xxxxxxx Therapy Systems Corp. or the Interim Supply Agreement, dated as of October 9, 2013, by and between the Company, LTS Xxxxxxx Therapy Systems Corp. and LTS Xxxxxxx Therapy Systems Corp. or (y) change, effect, event, occurrence, state of facts or development which individually or in the aggregate (i) results in any change or effect that is materially adverse to the business, financial condition, properties, assets, liabilities (contingent or otherwise) or results of operations of the Company, taken as a whole, (ii) prevents or materially impedes, interferes with, hinders or delays the consummation by the Company of the Merger or the other transactions contemplated by this Agreement, or (iii) results in the inability of the Company to manufacture at least 500,000 units of the Core Product per year; provided that none of the following shall be deemed, either alone or in combination, to constitute a Company Material Adverse Effect: (A) any change relating to the economy or securities markets in general, (B) any adverse change, effect, event, occurrence, state of facts or development attributable to conditions affecting the industry in which the Company participates, including any changes to reimbursement rates related to any Products, (C) any failure, in and of itself, by the Company to meet any internal or published projections, forecasts or revenue or earnings predictions for any period ending on or after the date of this Agreement (provided, that the underlying causes of such failure may be considered in determining whether a Company Material Adverse Effect has occurred), (D) the effect of any change in any applicable Law or GAAP or (E) any change, effect, event, occurrence, state of facts or development resulting from the execution, pendency or pursuit of the transactions contemplated hereby, including any Litigation resulting therefrom, or any action required pursuant to the terms of this Agreement; except, in the cases of clauses (A), (B) or (D) above, if such change, effect, event, occurrence, state of facts or development disproportionately affects the Company, in a material respect, as compared to other participants in the industry in which the Company participates.

  • Seller Material Adverse Effect means any event, change or occurrence that materially impairs or delays the ability of any of the Selling Parties to perform its obligations or to consummate the transactions under the Basic Documents or that otherwise materially threatens or materially impedes the consummation of the transactions under the Basic Documents.

  • Material Adverse Effect shall have the meaning assigned to such term in Section 3.1(b).

  • Purchaser Material Adverse Effect means any material adverse change in or material adverse effect on the ability of Purchaser to perform its obligations under this Agreement or to consummate the transactions contemplated hereby.

  • Serious Adverse Event means any adverse event that led to any of the following:

  • Material Adverse Change means any material adverse change in the business, condition (financial or otherwise), operations, performance, properties or prospects of the Borrower or the Borrower and its Subsidiaries taken as a whole.