ALTERNATIVE CELLULAR SOURCE OF NOX2 Sample Clauses

ALTERNATIVE CELLULAR SOURCE OF NOX2. Another possibility is that macrophages are known key players and that their activation and migration into cardiac tissue and production of TGFβ are significant events in the development of AngII induced cardiac fibrosis (Xxxxxx et al., 2004). In keeping with this, the ACE activity in monocyte-derived macrophages from pre-hypertensive patients has been shown to be increased (Xxxxxx et al., 2007). Also, in hypertensive rats, macrophages accumulate in the perivascular area, co-localising with fibroblasts, and promote the increased production of collagen (Sun et al., 2002b). Thus monocytes/macrophages could be another possible critical cellular source for Nox2 in AngII induced cardiac fibrosis. In the next chapter bone marrow-derived macrophages (BMM) are used to investigate the role of Nox2 in the ability of BMM to migrate as a measure of the cell’s ability to chemotax and infiltrate tissue. The dependence on Nox2 in this process, and the lack of it in Nox2-/- mice, could explain the elimination of fibrosis in vivo in Nox2-/- mice to angiotensin II or aldosterone stimulation.
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