Atherosclerotic Plaque Rupture Sample Clauses

Atherosclerotic Plaque Rupture. The progressive development of atherosclerotic plaques, also pose a serious risk to cardiac viability in the acute setting. The rupturing of an atherosclerotic plaque releases a thrombus into the coronary vasculature. As the coronary arteries branch into the prearterioles and arterioles, and become narrower, the thrombus can become lodged. This may severely restrict, or even completely impede blood flow to myocardium distal to the occlusion. In experimental animals with a coronary perfusion rate that is 10% of normal flow, cardiomyocytes begin to die after about 20 min [14-15]. In sufferers this acute event may cause severe unabated pain in the left arm and chest (unstable angina). As a result of restricted or inhibited perfusion a wave of cell death (infarction) begins to spreads from the subendocardial zone, which requires the most energy, outwards towards the epicardium [14]. If treatment is not administered in order to breakdown or remove the thrombus and restore blood flow, the most severely ischaemic regions of the myocardium will become unsalvageable within 60 minutes.
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Related to Atherosclerotic Plaque Rupture

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