Change in pharmacokinetics. Re- sults of pharmacokinetics measure- ments (i.e., biotransformation, extent of absorption, tissue distribution, and excretion) obtained in rats receiving the single inhalation exposure to the low dose of the test substance (Group B) shall be compared to the cor- responding results obtained in rats re- ceiving repeated inhalation exposures to the low dose of the test substance (Group F).
Change in pharmacokinetics. R e- s u l t s of p h a r m a co k i n e t ics m e a s ur e- m e n t s ( i . e., bio t r a n sfo r m a t io n , ex t e n t of a bso r p t io n , t iss u e dis t r ib u t io n , a n d exc r e t io n) ob t a i n ed i n r a t s r eceivi n g t h e s i n gle i nh a l a t io n expos ur e t o t h e low dose of t h e t es t s u bs t a n ce ( G r o u p B) s h a ll be co m p a r ed t o t h e co r - r espo n di n g r es u l t s ob t a i n ed i n r a t s r e- ceivi n g r epe a t ed i nh a l a t io n expos ur es t o t h e low dose of t h e t es t s u bs t a n ce ( G r o u p F ).
