Complement component immunoreactivity in the bronchial mucosa of asthmatics Sample Clauses

Complement component immunoreactivity in the bronchial mucosa of asthmatics. Global expression of complement components and their receptors was compared in the bronchial mucosa of a group of asthmatics with a range of disease severity and normal controls. The characteristics of the patients are summarised in Chapter 2, Table 2.1. Comparing all asthmatics with controls (Figure 3.3), increased immunoreactivity for C3 and C5b-9 was observed in the epithelium, smooth muscle and submucosa, but not the glandular areas of the bronchial mucosal sections. C3d immunoreactivity was elevated only in the epithelium. Expression of C3a and C5a receptors was detectable on cells in all areas of the mucosa (epithelium, submucosa, smooth muscle and glands) although the amount of expression did not differ in asthmatics and controls except in the case of the C3aR, expression of which was elevated on smooth muscle.
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