Common use of Dermal studies Clause in Contracts

Dermal studies. Unless precluded by corrosivity, the test substance shall be applied and kept on the skin for a minimum of 6 hours. At the time of re- moval of the porous covering, the treated area shall be washed with an appropriate solvent to remove any test substance that may be on the skin sur- face. Both the covering and the wash- ing shall be assayed to recover residual radioactivity. At the termination of the studies, each animal shall be sac- rificed and the exposed skin area re- moved. An appropriate section of the skin shall be solubilized and assayed for radio-activity to ascertain if the skin acts as a reservoir for the test substance. Studies on the dermal ab- sorption of corrosive test substances should be discussed with EPA prior to initiation.

Dermal studies. Unless precluded by corrosivity, the test substance shall be applied and kept on the skin for a minimum of 6 hours. At the time of re- moval of the porous covering, the treated area shall be washed with an appropriate solvent to remove any test substance that may be on the skin sur- face. Both the covering and the wash- ing shall be assayed to recover residual radioactivity. At the termination of the studies, each animal shall be sac- rificed and the exposed skin area re- moved. An appropriate section of the skin shall be solubilized and assayed for radio-activity to ascertain if the skin acts as a reservoir for the test substance. Studies on the dermal ab- sorption of corrosive test substances should be discussed with EPA prior to initiation.. Environmental Protection Agency § 795.228