Dosing and Dosing Schedules for Mirvetuximab Sample Clauses

Dosing and Dosing Schedules for Mirvetuximab. Soravtansine and Chemotherapeutic Agents The dose and schedule of study treatment are outlined in Table 5. The dose of chemotherapeutic agents will be calculated using body surface area (BSA). Institutional conventions may be used to calculate BSA. Table 5: Study Drug Doses and Schedules of Administration Group Drug Dose Dosing Schedule Arm 1 MIRV 6 mg/kg AIBW IV Day 1 of a 3-week cycle Arm 2 Pac 80 mg/m2 IV Days 1, 8, 15, and 22 of a 4-week cycle PLD 40 mg/m2 IV Day 1 of a 4-week cycle Topo 4 mg/m2 IV Days 1, 8, and 15 of a 4-week cycle Topo 1.25 mg/m2 IV Days 1 to 5 of a 3-week cycle Abbreviations: MIRV = mirvetuximab soravtansine; Pac = paclitaxel; PLD = pegylated liposomal doxorubicin; Topo = topotecan; AIBW = adjusted ideal body weight.
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