Evolution of WFDC family proteins Sample Clauses

Evolution of WFDC family proteins. The WFDC domain, with its characteristic 8 cysteine residues forming 4 disulphide bonds, has been highly conserved from mammals down to cnidarians and urochordates (Xxxxx, 2011). There are 18 WFDC domain containing proteins in man (fig. 1.1), most of which have not been characterized beyond the gene level (Bingle and Vyakarnam, 2008). Due predominantly to studies of the function and expression of SLPI and elafin, WFDC domain containing proteins have become associated with the homeostatic regulation of inflammation (Xxxxxxxxx et al., 1994) through a well- characterized serine protease inhibitor function (Sallenave, 2010). However both SLPI and elafin possess well characterised anti-microbial functions, including anti- bacterial, anti-viral and anti-fungal activity (Xxxxxxxx et al., 2006). Both SLPI and elafin therefore are proposed to protect tissues from protease induced damage,
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