Gastric pH Rationale (pH Pill) Sample Clauses

Gastric pH Rationale (pH Pill). The role of CFTR as a regulator of bicarbonate secretion is an old concept that is being increasingly appreciated in recent years. With the availability of a new minimally invasive tool, we have an extraordinary chance to study gastrointestinal pH in patients with CF in a multicenter manner. In CF patients with the G551D mutation, ivacaftor potentiates CFTR- mediated chloride secretion and leads to improved lung function and nutritional status.11 As part of the GOAL study, when subjects had GI pH measured using a pH pill before and after taking ivacaftor, bicarbonate secretion in the proximal GI tract improved, normalizing duodenal pH more efficiently.58 pH pill testing will be performed on a subset of subjects enrolled in the Part B CORE study to determine whether combination therapy with ivacaftor and lumacaftor can achieve a similar degree of improvement in GI tract bicarbonate secretion in CF patients who are homozygous for the F508del mutation.
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