HPA axis Sample Clauses

HPA axis. A primary function of the HPA axis is modulating the response to stress, which comprises an individual’s reaction to external and internal (psychological) stimuli and challenge. HPA axis activity begins with stimulatory input to the hypothalamus, which stimulates secretion of corticotropin-releasing-hormone (CRH) and vasopressin. CRH and vasopressin stimulate the secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary into the blood stream, which thereby stimulates the secretion of glucocorticoids (GCs; cortisol in humans, corticosterone in rodents) from the adrenal cortex. Once released, GCs exert their action primarily by binding to glucocorticoid receptors (GRs) found in many body tissues. GCs exert inhibitory effects on the HPA axis through activation of GRs in the hypothalamus, thereby executing negative feedback as a self-regulatory mechanism. The HPA axis is also involved in the modulation of a range of other physiological processes such as metabolism and immunity, as well as psychological processes such as memory.
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