Biological (re)activity Sample Clauses

Biological (re)activity. There is currently not agreement on how one should determine the biological surface reactivity of a MNM. Several more or less specific methods may be applied to determine the formation of reactive oxygen species (ROS), which is the key requirement in R6-1 v. 1.0 (2016). In D2.08, SOPs were tested on methods to assess the pH and oxidative reactivity in cell media using a Sensor Dish Reader (SDR) and synthetic biological fluids using an Atmosphere-pH-Temperature-controlled Stirred Batch Reactor (ATempH-SBR). In the SDR method, the ability of a MNM to affect the pH and O2 concentrations in cell media is measured in situ during specific cell incubation conditions. In this caser the difference between O2 concentrations in exposed and unexposed xxxxx can be used to indirectly calculate the change in redox potential and thereby the theoretical MNM-induced change in free electron equivalents in the media during incubation. This procedure is under development for technical specification in CEN. In the ATempH-SBR method, the pH, temperature and atmosphere is fixed to mimic conditions in e.g., a biological compartment such as the lung-lining or the phagolysosome. Fixing these conditions enables a rather accurate measurement of the redox potential in the test medium. The difference in redox potential between the MNM-free test media and the MNM-exposed media can be used to calculate the MNM-induced change in free electron equivalents during incubation in the tested compartment. In both cases future work should include further assessment of the data generated by using of these methods and their comparability with biological effects as well as other methods for determination of ROS. This should be followed by interlaboratory comparison studies and development of technical guidance documents.
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Biological (re)activity. The hypothalamus-pituitary-adrenal (HPA) axis, the inflammatory response, and abnormalities in metabolic function have all been found to be influenced by early life stress. In addition each of these systems has been associated independently with depression. This section will explore the link between abnormalities in each of these systems and depression, as well as the impact of early life stress upon them. Thus, they will be treated both as outcomes in their own right, as well as potential mechanisms for the pathogenesis of depression within the context of the influence of early life stress.

Related to Biological (re)activity

  • Substance Abuse The dangers and costs that alcohol and other chemical abuses can create in the electrical contracting industry in terms of safety and productivity are significant. The parties to this Agreement resolve to combat chemical abuse in any form and agree that, to be effective, programs to eliminate substance abuse and impairment should contain a strong rehabilitation component. The local parties recognize that the implementation of a drug and alcohol policy and program must be subject to all applicable federal, state, and local laws and regulations. Such policies and programs must also be administered in accordance with accepted scientific principles, and must incorporate procedural safeguards to ensure fairness in application and protection of legitimate interests of privacy and confidentiality. To provide a drug-free workforce for the Electrical Construction Industry, each IBEW local union and NECA chapter shall implement an area-wide Substance Abuse Testing Policy. The policy shall include minimum standards as required by the IBEW and NECA. Should any of the required minimum standards fail to comply with federal, state, and/or local laws and regulations, they shall be modified by the local union and chapter to meet the requirements of those laws and regulations.

  • Substance Abuse Program The SFMTA General Manager or designee will manage all aspects of the FTA-mandated Substance Abuse Program. He/she shall have appointing and removal authority over all personnel working for the Substance Abuse Program personnel, and shall be responsible for the supervision of the SAP.

  • Infectious Diseases The Employer and the Union desire to arrest the spread of infectious diseases in the nursing home. To achieve this objective, the Joint Health and Safety Committee may review and offer input into infection control programs and protocols including surveillance, outbreak control, isolation, precautions, worker education and training, and personal protective equipment. The Employer will provide training and ongoing education in communicable disease recognition, use of personal protective equipment, decontamination of equipment, and disposal of hazardous waste.

  • Substance Abuse Treatment Information Substance abuse treatment information shall be maintained in compliance with 42 C.F.R. Part 2 if the Party or subcontractor(s) are Part 2 covered programs, or if substance abuse treatment information is received from a Part 2 covered program by the Party or subcontractor(s).

  • Critical Illness Three (3) days per year, with pay, shall be granted in the case of a critical illness or accident to a member of the employee's immediate family as defined in Section 9.4.2. A statement by the physician verifying the need for the employee to be present with the immediate family member shall be attached to the absence form.

  • Substance Abuse Testing The Parties agree that it is in the best interest of all concerned to promote a safe working environment. The Union has no objection to pre-employment substance abuse testing when required by the Employer and further, the Union has no objection to voluntary substance abuse testing to qualify for employment on projects when required by a project owner. The cost and scheduling of such testing shall be paid for and arranged by the Employer. The Union agrees to reimburse the Employer for any failed pre-access Alcohol and Drug test costs.

  • Statistical, Demographic or Market-Related Data All statistical, demographic or market-related data included in the Registration Statement, the Disclosure Package or the Prospectus are based on or derived from sources that the Company believes to be reliable and accurate and all such data included in the Registration Statement, the Disclosure Package or the Prospectus accurately reflects the materials upon which it is based or from which it was derived.

  • Study An application for leave of absence for professional study must be supported by a written statement indicating what study or research is to be undertaken, or, if applicable, what subjects are to be studied and at what institutions.

  • Electrical appliance safety The Hirer shall ensure that any electrical appliances brought by them to the premises and used there shall be safe, in good working order, and used in a safe manner in accordance with the Electricity at Work Regulations 1989. Where a residual circuit breaker is provided the hirer must make use of it in the interests of public safety.

  • Human Leukocyte Antigen Testing This plan covers human leukocyte antigen testing for A, B, and DR antigens once per member per lifetime to establish a member’s bone marrow transplantation donor suitability in accordance with R.I. General Law §27-20-36. The testing must be performed in a facility that is: • accredited by the American Association of Blood Banks or its successors; and • licensed under the Clinical Laboratory Improvement Act as it may be amended from time to time. At the time of testing, the person being tested must complete and sign an informed consent form that also authorizes the results of the test to be used for participation in the National Marrow Donor program.

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