IQGAP family of scaffold proteins Sample Clauses

IQGAP family of scaffold proteins. The IQGAP family of scaffold proteins has received a lot of attention as Rac1 and Cdc42 effectors (Xxxxxx and Xxxxx, 2003). IQGAP1 was the first member of the family to be discovered and was initially shown to interact with activated Rac1 and Cdc42 (figure 1.5) and becoming enriched at COS7 cell areas with membrane ruffling as well cell junctions of MDCK cells (Xxxxxx et al., 1996). Since then, IQGAP1 has been implicated in various cytoskeletal processes including directional cell migration, cell adhesion and cell polarity while another two IQGAP members, IQGAP2 and IQGAP3 have also been identified sharing some functionality but also harbouring unique properties (Xxxxx et al., 2015). Recently, a genetic profiling screen based on approximately 200 tumours that was performed at the Breast Cancer Now Unit of Guy’s Hospital and King’s College London (xx Xxxxxxxx et al., 2013) revealed that IQGAP3 is upregulated in TNBC compared to other classes of breast cancer and normal breast tissue (figure 1.6).