IQGAP1 Sample Clauses

IQGAP1. IQGAP1 has been associated with multiple cellular processes by interacting with more than 130 binding partners thanks to its multifunctional domains (Xxxxxx et al., 2015). Initially it was observed to bind the actin cytoskeleton and active Cdc42 and Rac1 but not RhoA in a Ca2+/calmodulin dependent manner thereby acting as a cross-linking protein and scaffold in regulating the actin cytoskeleton (Xxxxxxx et al., 1997; Xx et al., 1999; Xxxxxx et al., 1996). The interaction of IQGAP1 with the Rho GTPases has been extensively described; recently it was proposed that the GRD domain interacts with Rac1 and Cdc42 with different affinities while the RasGAP-CT is also important in mediating the interaction of IQGAP1 with the Rho GTPases (Xxxxx et al., 2017). Additionally, the regions on IQGAP1 interacting with Rac1 and Cdc42 are overlapping but not identical (Nouri et al., 2017). In fact, IQGAP1 has been shown to maintain the active state of Cdc42 by inhibiting its GTPase activity (Xxxxx-Xxxxxxxx et al., 2002). IQGAP1 mediated regulation of Rac1 appears to be more complex as it has been shown to promote Rac1 mediated migration in glioma cells (Xx et al., 2009) while promoting Rac1 deactivation by interacting with RacGAP1 in U-2OS osteosarcoma cells (Xxxxxxxxx et al., 2013). Since then, IQGAP1 has also been reported to bind GTP bound prenylated RhoA (Xxxxxxx et al., 2012). In addition, IQGAP1 has been implicated in cell polarisation as it has been reported to bind CLIP- 170 which in turns interacts with elongating microtubules at the cell periphery (Xxxxxx et al., 2001; Xxxxx and Xxxxxxxx, 2010). This interaction allows a complex between CLIP-170, IQGAP1 and activated Rac1/Cdc42 to be formed which in turn recruits elongating microtubules towards the leading cell edge of Vero cells ultimately implicating IQGAP1 in cell polarisation (Xxxxxx et al., 2001). The implication of IQGAP1 in directional cell migration was further confirmed when Xxxx et al., also showed that IQGAP1 is localised close to the leading edge of MDA-MB-231 cells (Xxxx et al., 2013). This localisation is mediated by the type Iγ phosphatidylinositol 4-phosphate 5- kinase (PIPKIγ) recruiting IQGAP1 at the leading edge where IQGAP1 is also able to bind Phosphatidylinositol 4,5 bisphosphate (PIP2) (Xxxx et al., 2013). The interaction between IQGAP1 and PIP2 confers the necessary conformational change that triggers IQGAP1 to activate key actin polymerisation regulators N-WASP and Arp2/3 complex. Loss of t...
Sample 1
AutoNDA by SimpleDocs

Related to IQGAP1

  • CONTRACTOR NAME CHANGE An amendment is required to change the Contractor's name as listed on this Agreement. Upon receipt of legal documentation of the name change the State will process the amendment. Payment of invoices presented with a new name cannot be paid prior to approval of said amendment.

  • Xxxxxxxx, 121 Cal App.4th Supp. 7 (2004), CIV Code 1962 Colorado $50.00 or 5% of past due rent C.R.S. § 00-00-000 Connecticut Not defined No statute Delaware 5% of the monthly rent amount Title 25, § 5501(d) Florida Not defined No statute Georgia “All contracts for rent shall bear interest from the time the rent is due” Hawaii 8% of the monthly rent amount § 521-21(f) Idaho Not defined No statute Illinois Outside Chicago – Not defined Chicago only – $10.00 per month for the first $500.00 in monthly rent plus five percent per month for any amount in excess of $500.00 in monthly rent for the late payment of rent. No statute 5-12-140(h) Indiana Not defined No statute Iowa If the rent does not exceed $700/month, the late fee cannot exceed more than $12/day per day or $60/month. If the rent is greater than $700/month, the late cannot exceed more than $20/day or $100/month.

  • Eindgebruikers binnen de Amerikaanse overheid De Apple software en de bijbehorende documentatie zijn “Commercial Items”, zoals omschreven in 48 C.F.R. §2.101, en bestaan uit “Commercial Computer Software” en “Commercial Computer Software Documentation”, zoals beschreven in 48 C.F.R. §12.212 of 48 C.F.R. §227.7202, afhankelijk xxx xxxxx paragraaf van toepassing is. Overeenkomstig 48 C.F.R. §12.212 of 48 C.F.R. §227.7202-1 tot en met 227.7202-4, afhankelijk xxx xxxxx paragraaf van toepassing is, xxxxxx de “Commercial Computer Software” en “Commercial Computer Software Documentation” aan eindgebruikers binnen de Amerikaanse overheid (a) alleen als “Commercial Items” in licentie gegeven en (b) alleen met de rechten die xxxxxx verleend aan alle andere eindgebruikers conform de voorwaarden die hierin xxxxxx genoemd. Ongepubliceerd: rechten voorbehouden krachtens de auteursrechtwetgeving van de Verenigde Staten.

  • MSEA SEIU shall have exclusive rights to payroll deduction of membership dues, service fees, and premiums for current MSEA-SEIU spon- sored insurance programs. Deductions for other programs may be mutually agreed to by the parties.

  • WSIB & LTD An Employee who is receiving benefits under the Workplace Safety and Insurance Act, or under a LTD plan, is not entitled to benefits under a school board’s sick leave and short term disability plan for the same condition unless the employee is on a graduated return to work program then WSIB/LTD remains the first payor. For clarity, where an employee is receiving partial benefits under WSIB/LTD, they may be entitled to receive benefits under the sick leave plan, subject to the circumstances of the specific situation. During the interim period from the date of the injury/incident or illness to the date of the approval by the WSIB/LTD of the claim, the employee may access sick leave and short term leave and disability coverage. A reconciliation of sick leave deductions made and payments provided, will be undertaken by the school board once the WSIB/LTD has adjudicated and approved the claim. In the event that the WSIB/LTD does not approve the claim, the school board shall deal with the absence consistent with the terms of the sick leave and short term leave and disability plans.

  • BANCO BILBAO VIZCAYA ARGENTARIA, S A. as swap counterparty (in such capacity, the “Counterparty”); and

  • Agreement Xxx 0000 Part 3 Provisions relating to Balmoral South Iron Ore Project and certain other matters Division 2 Main provisions s. 14

  • Drug Free Work Place Grantee shall establish and maintain a drug-free work place policy.

  • Rubric The rubrics are a scoring tool used for the Educator’s self-assessment, the formative assessment, the formative evaluation and the summative evaluation. The districts may use either the rubrics provided by ESE or comparably rigorous and comprehensive rubrics developed or adopted by the district and reviewed by ESE.

  • Gross Beta Flags A = Result acceptable, Bias <= +/- 50% with a statistically positive result at two standard deviations (Result/Uncertainty > 2, i.e., the range encompassing the result, plus or minus the total uncertainty at two standard deviations, does not include zero). N = Result not acceptable, Bias > +/- 50% or the reported result is not statistically positive at two standard deviations (Result/Uncertainty <= 2, i.e., the range encompassing the result, plus or minus the total uncertainty at two standard deviations, includes zero). Uncertainty Flags:

Time is Money Join Law Insider Premium to draft better contracts faster.