MtrA Sample Clauses

MtrA. The AraC-XylS family transcriptional regulator MtrA had been shown to activate expression of the mtrCDE efflux operon when gonococci are exposed to sublethal concentrations of the HA TritonX-100, which is a substrate of the MtrCDE efflux pump. It has been proposed that induction of pump expression serves as an efficient defense mechanism that prepares the gonococcus to expel antibiotics or host defense factors thus ensuring infectivity and survival (164). Utilizing a mouse infection model it has been demonstrated that a gonococcal strain bearing a mutation in mtrA is significantly less fit in vivo, indicating the importance of this DNA-binding protein for gonococcal pathogenicity (206). Unpublished observations by Zalucki and Xxxxxx suggest that MtrA is a global regulatory protein and acts directly or indirectly to activate or repress a number of gonococcal genes in addition to the mtrCDE efflux operon.
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