Oxford Project to Investigate Memory Sample Clauses

Oxford Project to Investigate Memory and Aging (OPTIMA) Samples from this source are covered by REC project reference 10/H0703/30. On enrolment, participants in OPTIMA consented for their tissue to be used in research. As part of OPTIMA participants underwent detailed clinical evaluations approximately every six months until death. Information on medication was also collected at most visits. I wrote an application to OPTIMA for DNA samples relating to cases which met the below inclusion/exclusion criteria: Inclusion criteria: For pathologically confirmed samples: • Meet the Consortium to Establish a Registry for Alzheimer's disease (CERAD) criteria for probable or definite Alzheimer’s disease (Xxxxx, 1991) or the National Institute of Aging (XXX-XXXXXX) criteria for high likelihood of Alzheimer's disease (Xxxxx et al., 1997); Or for clinically diagnosed samples: • Operationalised clinical diagnosis of AD at death made using National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable Alzheimer's disease (XxXxxxx et al., 1984).
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