Parentral factor Xa inhbitors Sample Clauses

Parentral factor Xa inhbitors. Idraparinux sodium (SR34006) is a synthetic pentasaccharide administered subcutaneously with a similar chemical structure and same method of action as fondaparinux but with a much longer elimination half-life, making feasible a once-a-week dosing scheme. The drug never reached the market due to concerns of excessive bleeding following the use of this agent, documented in the AMADEUS trial which tested its efficacy in preventing thromboem- bolic events, against adjusted dose vitamin K antagonists, in patients with atrial fibrillation255. Instead Idrabiotaparinux (SSR126517), a biotinylated version of idraparinux, was developed. Despite the similar mode and duration of action, Idrabiotaparinux can be safely inactivated, if this becomes necessary, by i.v. infusion of xxxxxx that neutralizes its anti-Xa activity256. Results from phase III trials, assessing idrabiotaparinux’s efficacy in preventing thromboembolism in the setting of deep vein thrombosis and atrial fibrillation, are expected257, 258. Otamixaban (XRP0673) is a short-acting, intravenously administered, selective inhibitor of factor Xa. It has already been tested in two phase II trials in the setting of routine PCI interventions and NSTEMI ACS ((Prevention of Ischemia with Anti-Xa inhibition in acute coronary syndromes 1 - Thrombolysis in Myocardial Infarction 42, SEPIA-ACS1 TIMI 42 and Otamixaban in Comparison to Heparin in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention, SEPIA-PCI) with promising results259, 260. A Phase III trial, comparing it to standard therapy in high risk ACS patients undergoing early invasive strategy, is currently recruiting patients261. Ultra low molecular weight heparin (AVE5026) is a hemi-synthetic molecule with an average molecular weight of 2000 to 3000 Da (almost half compared to other LMWH). It has nearly pure anti-Xa activity and is currently being assessed in phase III trials as an alternative to standard therapy for prevention of DVT thromboembolism262-264.
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Related to Parentral factor Xa inhbitors

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