Pregnenolone-16α-carbonitrile (PCN Sample Clauses

Pregnenolone-16α-carbonitrile (PCN. Pregnenolone-16α-carbonitrile is a potent activator of rodent PXR but not human PXR (Xxxxx, et al., 2000) and does not activate CAR (Wei et al., 2002).The concentration of PCN used, 10 µM, was taken from previous literature (Xxxxx, et al., 2000). After 48 hours treatment of 10 µM PCN with or without β- NF (100 µM-1µM), CYP3A2 protein expression was observed, but there was no significant effect of β-NF (Figure 3.5b).
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Related to Pregnenolone-16α-carbonitrile (PCN

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