Quantitative assessment of calcification on CT Sample Clauses

Quantitative assessment of calcification on CT. Scans were assessed by two raters (a clinical scientist [SE] and a Consultant Radiologist [DD]) who were blinded to subject demographics, BMD results, lateral VFA scores and to each other’s readings. Scan images were identified by the subject’s study number only. Scans were labelled as scan 1 and scan 2 on the workstation to enable the viewer to distinguish the first from the second scan. Each 3mm transverse slice was analysed individually and calcified deposits were defined as any area greater that 1mm2, within the blood vessel being assessed, with an attenuation coefficient of ≥ 130 Hounsfield units (HU). Individual calcified deposits on each transverse CT slice were identified by the rater and then a ‘seeding’ tool was used to delineate each deposit using the thresholding method as described in Chapter 2. Calcified deposits were labelled according to anatomical location and deposit number; for example a calcified deposit located in the AA was labelled as AAORTA Dep 1 (Figure 3.2 and 3.3). The total Agatston [349], modified Agatston [553] and volume scores [554] were calculated by summing the scores obtained for all cross-sectional slices (Section 2.12, Chapter 2). Each scan was analysed twice by each rater with a minimum of two weeks between the first and second analysis, with each scan taking approximately 45 mins to analyse. Figure 3.1 Transaxial CT image showing normal aortic anatomy with no calcified deposits in the aorta (red arrow) located anterior to lumbar vertebral body L2. Figure 3.2 Transaxial CT image showing a calcified deposit within the abdominal aorta with a ROI around the calcified deposit (shown in red). Calcium scores for this deposit were: Agatston 20 AU, modified Agatston score 472 AU and volume score 0.017cm3. Figure 3.3 Transaxial CT image showing a calcified deposit within the right iliac artery (red arrow) with a ROI around a calcified deposit (shown in red). Calcium scores for this deposit were: Agatston score 28 AU, modified Agatston score 686.6 AU and volume score 0.021cm3
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