Rho-Kinase (ROCK Sample Clauses

Rho-Kinase (ROCK. Inhibitors Rho-kinase (ROCK) inhibits myosin phosphatase activity by phosphorylating the myosin- binding subunit of the enzyme, promoting actin-myosin-mediated contractile force gen- eration, thus resulting in the augmented vascular smooth muscle contraction in a calcium- independent xxxxxx000, 125. The activation of ROCK is involved in the regulation of vascular tone, endothelial dysfunction, inflammation and remodeling .The inhibition of ROCK has a beneficial effect in a variety of cardiovascular disorders. Evidence from animal models and from clinical use of ROCK in- hibitors, such asY-27632, fasudil supports the hypothesis that ROCK is a potential therapeutic target126.
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