Apolipoprotien A-1 Sample Clauses

Apolipoprotien A-1. (Apo A-1) Milano infusion ApoA-I Milano is a variant of apolipoprotein A-I identified in individuals in rural Italy who exhibit very low levels of HDL (10-30 mg/dl), yet despite of that had a reduced atherosclerotic disease burden and longer lives102, 103. Infusion of recombinant Apo A-I Milano–phospholipid complexes (ETC-216) produces rapid regression of atherosclerosis in animal models, which can occur in as little as 48 hs104, 105. Moreover, it was recently found in animal studies that ApoA-1 Milano administration not only induced plaque size regression but was also as- sociated with a significant reduction in markers of plaque vulnerability, suggesting further plaque stabilization106.
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Apolipoprotien A-1. (Apo A-1) Milano infusion This therapy was piloted in humans when ETC-216, recombinant apolipoprotein A-I Milano complexed with phospholipid, was randomly infused in 57 patients within 2 weeks of an acute coronary syndrome (ACS) over 5 weekly treatments171. There was significant reduction in intravascular ultrasound (IVUS)-measured coronary atheroma burden with ETC-216, with 1 patient reported to have a significant rise in transaminases171. In a trial of 47 patients after an acute coronary syndrome, recombinant apolipoprotein A-I Milano infusion was associated with reverse coronary remodeling and reduced atheroma burden172. A future study will assess the effects of CER-001, an ApoA-I-based HDL mimetic, on indices of atherosclerotic plaque progression and regression as assessed by IVUS measurements in patients with ACS173.
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