Splicing and SR proteins Sample Clauses

Splicing and SR proteins. SR proteins are amongst the first components that interact with the pre-mRNA transcript during splicing. They have an essential role during alternative splicing, acting as regulators of mRNA metabolism (Xxxxxx, 1996; Long and Xxxxxxx, 2009). SR proteins promote exon inclusion by binding to ESE motifs on pre- mRNA through their RRM. They bind almost exclusively to exonic regions, probably because of their role in the recruitment of other splicing factors that may stabilize their interaction with the pre-mRNA (Xxx et al., 2005). The binding of SR proteins to ESE motifs enhances spliceosome assembly and promotes exon inclusion in two ways:
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