Alternatively spliced tau exons Sample Clauses

Alternatively spliced tau exons. 1.3.1.1 Tau exon 2 and 3 The amino-terminal of tau proteins contains a 29- or 58-amino acid insert encoded for by exon 2 alone (1 N-terminal insert) and exons 2 and 3 (2 N-terminal inserts) respectively (Xxxxxxx et al., 1989a) (Figure 1.2). These N- terminal inserts of tau are expressed in an adult-specific manner. Exon 2 can be expressed independently in the tau mRNA transcript; however exon 3 is never expressed independently (Xx et al., 2003). By default, the expression of exon 3 is exclusion and dependent on the presence of exon 2 (Xxxxxxxxx, 2005; Xxxxxxxxx et al., 1995) while the default splicing pattern of exon 2 is inclusion (Xxxxxxxxx et al., 1995). Tau interacts with neuronal plasma membrane through its N-terminal and is proposed to mediate the microtubule-plasma membrane interaction (Xxxxxx et al., 1995).