Common use of Study Payments Clause in Contracts

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 240.00 16 nights Duration of Follow-Up Period (Discharge to Follow-up Up Phone Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 days Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 1,200.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 5,530.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS – PART A Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 20 240.00 18 $5,100.00 Washout Between Periods $15.00 12 $180.00 4,320.00 Duration of Follow-Up Period (Discharge to Follow-up Up Call) $15.00 26 $390.00 Follow-up visit Up Visit to CRU $250.00 1 $250.00 Follow-Follow Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 1,350.00 $1,450.00 1,350.00 Total Payment Part A $7,470.00 Cohort 2 6,410.00 STUDY PARTICIPANTS – PART B (DOSING SEQUENCE 1) Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 16 245.00 23 $4,080.00 Washout Between Periods $15.00 9 $135.00 5,635.00 Duration of Follow-Up Period (Discharge to Follow-up Up Call) $15.00 26 $390.00 Follow-up visit Up Visit to CRU $250.00 1 $250.00 Follow-Follow Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 1,610.00 $1,210.00 1,610.00 Total Payment Part B $6,165.00 Cohort 3 7,985.00 STUDY PARTICIPANTS – PART B (DOSING SEQUENCE 2) Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 245.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 4,410.00 Duration of Follow-Up Period (Discharge to Follow-up Up Call) $15.00 26 $390.00 Follow-up visit Up Visit to CRU $250.00 1 $250.00 Follow-Follow Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 1,260.00 $1,330.00 1,260.00 Total Payment Part B $6,660.00 6,410.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 20 $5,100.00 Washout Between Periods $15.00 240.00 12 $180.00 2,880.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 30 $390.00 Follow-up visit $250.00 1 $250.00 450.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 900.00 $1,450.00 900.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 4,330.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law. In some countries, compensation may not be allowed due to immigration status • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 240.00 16 nights Duration of Follow-Up Period (Discharge to Follow-up Up Phone Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 days Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 1,200.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 5,530.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law. In some countries, compensation may not be allowed due to immigration status • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study • You may be offered transportation to and from the study site at no additional charge to you The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods $15.00 305.00 12 $180.00 nights Duration of Follow-Up Period Participation (Discharge to Follow-up Callphone call) $15.00 26 $390.00 days Follow-up visit Up Visit to CRU $250.00 1 $250.00 0 planned Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 1,085.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 5,235.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: •  If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate •  You will not be given the study completion bonus if you drop out of the study early •  Partial payments are planned during the study. Details will be provided at screening •  A final payment will be provided to you within 2 weeks of finishing the study •  If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law; in some countries compensation may not be allowed due to immigration status  Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study  You may be offered transportation to and from the study site and lodging at no additional charge to you The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 225.00 12 Washout Period Between Doses $5,100.00 Washout Between Periods $15.00 12 $180.00 Duration of 100.00 0 Follow-Up Period (Discharge Visit to Follow-up Call) $15.00 26 $390.00 Follow-up visit CRU $250.00 1 $250.00 0 planned Time Between Discharge and Follow-Up Phone Call $100.00 1 $100.00 4 weeks Completion Bonus $1,450.00 $1,450.00 900.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 4,000.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 20 250.00 25 $5,100.00 Washout Between Periods 6,250.00 Time from first dose of Saxenda to admission $15.00 12 28 $180.00 420.00 Duration of Follow-Up Period (Discharge to Follow-up Up Call) $15.00 26 24 $390.00 360.00 Follow-up visit Up Visit to CRU $250.00 1 5 $250.00 Follow-1,250.00 Follow Up Phone Call $100.00 1 $100.00 Procedures at Home $75.00 28 $2,100.00 Completion Bonus $1,450.00 1,926.00 $1,450.00 1,926.00 Total Payment Part D $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 12,406.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law; in some countries compensation may not be allowed due to immigration status • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study • You may be offered transportation to and from the study site at no additional charge to you The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 230.00 18 Washout Period Between Doses $5,100.00 Washout Between Periods $15.00 12 $180.00 Duration of 100.00 0 Follow-Up Period (Discharge Visit to Follow-up Call) $15.00 26 $390.00 Follow-up visit CRU $250.00 1 $250.00 Follow-0 planned Time Between Discharge and Follow- Up Phone Call $100.00 1 $100.00 4 weeks Completion Bonus $1,450.00 $1,450.00 1,260.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 5800.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 20 215.00 3 $5,100.00 Washout Between Periods $15.00 12 $180.00 645.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 28 $390.00 Follow-up visit $250.00 1 $250.00 420.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 300.00 $1,450.00 300.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 1,465.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 20 300.00 23 $5,100.00 Washout Between Periods 6,900.00 Time from first dose of Saxenda to admission $15.00 12 27 $180.00 405.00 Duration of Follow-Up Period (Discharge to Follow-up Up Call) $15.00 26 27 $390.00 405.00 Follow-up visit Up Visit to CRU $250.00 1 5 $250.00 Follow-1,250.00 Follow Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 2,046.00 $1,450.00 2,046 Total Payment Part D $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 11,106.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: •  If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate •  You will not be given the study completion bonus if you drop out of the study early •  Partial payments are planned during the study. Details will be provided at screening •  A final payment will be provided to you within 2 weeks of finishing the study •  Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 240.00 9 nights Duration of Follow-Up Period (Discharge to Follow-up Call) Up Phone Call $15.00 15 26 $390.00 Follow-up visit $250.00 1 $250.00 days Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 675.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 3,325.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-safety- related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods 390.00 5 nights Admission to Day 60 $15.00 12 $180.00 Duration of 60 days Follow-Up Period (Discharge to Follow-up Call) beyond 60 days $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 25.00 212 days Follow-Up Phone Call Visit to CRU $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 500.00 8 visits Total Payment $7,470.00 Cohort 2 12,150.00 Groups 3 through 8, and 12 (if done) STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 16 $4,080.00 Washout Between Periods 390.00 5 nights Admission to Day 60 $15.00 9 $135.00 Duration of 60 days Follow-Up Period (Discharge to Follow-up Call) beyond 60 days $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 25.00 482 days Follow-Up Phone Call Visit to CRU $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 500.00 11 visits Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 20,400.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests. If you have any unresolved events that may be related to having an immune response to the study drug you will be asked to stay on study for extended follow-up (beyond the last expected study visit day) and will return for follow-up visit(s) every 3 months. You will be compensated $2750.00 for every 90 days you remain on study.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: •  If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate •  You will not be given the study completion bonus if you drop out of the study early •  Partial payments are planned during the study. Details will be provided at screening •  A final payment will be provided to you within 2 weeks of finishing the study •  If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law. In some countries, compensation may not be allowed due to immigration status  Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 240.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 nights Duration of Follow-Up Period (Discharge to Follow-up Up Phone Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 27 days Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 1,500.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 6,805.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law; in some countries compensation may not be allowed due to immigration status • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study • You may be offered transportation to and from the study site at no additional charge to you The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS IN STUDY TREATMENT SEQUENCES 1 & 2 Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 260.00 21 Washout Period Between Doses $5,100.00 Washout Between Periods $15.00 12 $180.00 Duration of 100.00 2 weeks Follow-Up Period (Discharge Visit to Follow-up Call) $15.00 26 $390.00 Follow-up visit CRU $250.00 1 $250.00 Follow-None Time Between discharge and Follow- Up Phone Call $100.00 1 $100.00 4 weeks Completion Bonus $1,450.00 $1,450.00 1,365.00 Total Payment $7,470.00 Cohort 2 7425.00 STUDY PARTICIPANTS IN STUDY TREATMENT SEQUENCES 3 & 4 Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 16 260.00 14 Washout Period Between Doses $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of 100.00 1 week Follow-Up Period (Discharge Visit to Follow-up Call) $15.00 26 $390.00 Follow-up visit CRU $250.00 1 $250.00 Follow-None Time Between discharge and Follow- Up Phone Call $100.00 1 $100.00 4 weeks Completion Bonus $1,210.00 $1,210.00 910.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 5050.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: •  If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate •  You will not be given the study completion bonus if you drop out of the study early •  Partial payments are planned during the study. Details will be provided at screening •  A final payment will be provided to you within 2 weeks of finishing the study •  If total payment by Pfizer is $600.00 or more in a calendar year, your payment will be reported to the Internal Revenue Service in accordance with Federal tax law; in some countries compensation may not be allowed due to immigration status  Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study  You may be offered transportation to and from the study site and lodging at no additional charge to you The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 225.00 20 Washout Period Between Doses $5,100.00 Washout Between Periods $15.00 12 $180.00 Duration of 100.00 0 Follow-Up Period (Discharge Visit to Follow-up Call) $15.00 26 $390.00 Follow-up visit CRU $250.00 1 $250.00 Follow-0 planned Time Between Discharge and Follow- Up Phone Call $100.00 1 $100.00 4 weeks Completion Bonus $1,450.00 $1,450.00 1,500.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 6,400.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: •  If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate •  You will not be given the study completion bonus if you drop out of the study early •  Partial payments are planned during the study. Details will be provided at screening •  A final payment will be provided to you within 2 weeks of finishing the study •  Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay Stay* $255.00 20 $5,100.00 Washout Between Periods $15.00 12 $180.00 240.00 18 nights Duration of Follow-Up Period (Discharge to Follow-up Up Phone Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 27 days Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 $1,450.00 1,350.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 6,175.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay Stay* $300.00 Daytime Stay $190.00 *Overnight stay rates include an increase for COVID restriction inconveniences Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days/Weeks) Total Overnight Stay $255.00 20 240.00 22 $5,100.00 Washout Between Periods $15.00 12 $180.00 5,280.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 28 $390.00 Follow-up visit $250.00 1 $250.00 420.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,450.00 1,650.00 $1,450.00 1,650.00 Total Payment $7,470.00 Cohort 2 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 9 $135.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,210.00 $1,210.00 Total Payment $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 7,450.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.

Study Payments. The payment for completing the entire study is listed below. Please be aware that: • If you do not follow instructions (including those listed in the New Haven CRU House Rules), if you are late for blood draws, or if you miss procedures, your payment may be reduced. You will be paid a prorated amount based on the extent of your participation if: o You are not able to complete the study o You choose to leave the study o You are withdrawn from the study early by the study investigator for non-safety-related issues o The study is stopped early o You are qualified but not chosen to participate • You will not be given the study completion bonus if you drop out of the study early • Partial payments are planned during the study. Details will be provided at screening • A final payment will be provided to you within 2 weeks of finishing the study • Pfizer may use information resulting from the study or samples collected in the study to develop products or processes. Pfizer may make a profit from these. There are no plans to pay you or provide you with any products developed from this research. Pfizer will own all products or processes that are developed using information or samples from the study The decision to admit you into the study is based upon results of pre-study requirements. No one is guaranteed a place in the study until the first dose is complete. Enough numbers of participants will be brought in to be sure we fill the study. Cohort 1 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 20 225.00 4 $5,100.00 Washout Between Periods $15.00 12 $180.00 900.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit Up Visit (females able to have children only) $250.00 1 $250.00 Follow-Up Phone Call (males and females unable to have children only) $100.00 1 $100.00 Completion Bonus $1,450.00 360.00 $1,450.00 360.00 Total Payment Males and females unable to have children $7,470.00 Cohort 2 1,750.00 Females able to have children $1,900.00 Groups 6 & 7 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay $255.00 16 $4,080.00 Washout Between Periods $15.00 240.00 9 $135.00 2,160.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit Up Visit (females able to have children only) $250.00 1 $250.00 Follow-Up Phone Call (males and females unable to have children) $100.00 1 $100.00 Completion Bonus $1,210.00 675.00 $1,210.00 675.00 Total Payment Males and females unable to have children $6,165.00 Cohort 3 STUDY PARTICIPANTS Type of Activity Payment per Activity Total Number (Days) Total Overnight Stay 3,325.00 Females able to have children $255.00 18 $4,590.00 Washout Between Periods $15.00 0 $0.00 Duration of Follow-Up Period (Discharge to Follow-up Call) $15.00 26 $390.00 Follow-up visit $250.00 1 $250.00 Follow-Up Phone Call $100.00 1 $100.00 Completion Bonus $1,330.00 $1,330.00 Total Payment $6,660.00 3,475.00 BACK-UP PARTICIPANTS Type of Activity Payment per Activity Overnight Stay $300.00 Daytime Stay $190.00 Additional payments are made if we ask you to return to the CRU or to outside medical providers for additional tests ($250.00 per visit). During times that you need to stay in the CRU, you will not be paid more for repeat or added tests.