Unusual receptor subunit assemblies Sample Clauses

Unusual receptor subunit assemblies. There is also evidence of promiscuous subunit assembly between different members of the Cys- loop family. For example, GABAA γ2s can co-assemble with glycine α subunits to form functional glycine receptors (Li and Xxxxxxxxx 2007). There is also evidence of co-localization of α1 glycine receptor subunit with the GABAA γ2 and GABAA receptor subunits in spinal cord but not retina (Frazao, Nogueira et al. 2007). Also, glycine α and GABAA γ subunit mRNA may be co-expressed in large DRG neurons (Furuyama, Sato et al. 1992). In sum, earlier conclusions that classical GABAA receptors are essential for PAD based on pharmacological observations can no longer be viewed as definitive.
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