USE OF ANTIXA LEVELS DURING RIVAROXABAN TREATMENT Sample Clauses

USE OF ANTIXA LEVELS DURING RIVAROXABAN TREATMENT. The manufacturers of rivaroxaban state that the drug plasma levels do not need to be monitored, since there a large therapeutic index. Current guidance recognises this, but states that, in situations when it is important to know if rivaroxaban is present in the plasma in clinically relevant levels, a normal antiXa measurement can exclude this. (Ikeda & Tachibana, 2015) Thus, if an urgent or invasive procedure is required, or in the situation of a haemorrhage or major trauma, antiXa measurement is suggested. (Xxxxxx et al., 2014) AntiXa levels are also recommended if a rivaroxaban concentration quantitation is required, for example, if a patient has had a bleed or recurrent VTE while taking rivaroxaban. (Xxxxx et al., 2012; Xxxxxxx, 2013)
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