Zero-Order Dermal Absorption Sample Clauses

Zero-Order Dermal Absorption. 43 5.1.3.3. Excretion 43 5.1.4. Acute Oral Toxicity 43 5.1.5. Subchronic or Chronic Systemic Toxic Effects 44
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Zero-Order Dermal Absorption. ‌ 2 Exposure scenarios involving the assumption of zero-order dermal absorption require an estimate of 3 dermal permeability (Kp) in units of cm/hour. No experimental data were found on the dermal 4 permeability rate of indaziflam. In the absence of experimental data, FS risk assessments use a QSAR 5 algorithm developed by U.S. EPA (SERA 2014a). The U.S. EPA algorithm is derived from an analysis of 6 95 organic compounds with Kow values ranging from 0.0056 to 309,000 and molecular weights 7 ranging from 30 to 770 g/mole (U.S. EPA/ORD 2007). These ranges of Kow values and molecular 8 weights encompass the estimates of the corresponding values for indaziflam. As detailed in 9 Worksheet B03a of Attachment 1, the estimated dermal permeability (Kp) is approximately 0.0025 10 (95% Confidence Interval: 0.0017 to 0.0038) cm/hour. 11 5.1.3.3. Excretion‌ 12 Excretion rates are typically not used quantitatively in FS risk assessments. However, excretion half- 13 lives can be used to infer the effect of longer-term exposures on body burden, based on the plateau 14 principle. As described in SERA 2014a, this principle can be applied to a compound that is eliminated

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