GENZYME GENZYME TRANSGENICS CORP. TRANSGENICS 175 CROSSING BOULEVARD, SUITE 410 PO. BOX 9322 FRAMINGHAM, MA 01701-9322 TEL 508-620-9700 FAX 508-370-3797 MANAGEMENT AGREEMENT This Severance Agreement, dated as of June 14, 2000, is among Genzyme...Severance Agreement • May 6th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
W I T N E S S E T H:Loan Agreement • August 13th, 1997 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Arkansas
EIGHTH AMENDMENT TO REVOLVING CREDIT AGREEMENT THIS EIGHTH AMENDMENT TO REVOLVING CREDIT AGREEMENT (this "Eighth Amendment") is made and entered into as of March 20, 1998, by and among GENZYME TRANSGENICS CORPORATION, a Massachusetts corporation...Revolving Credit Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.52.1 AMENDED AND RESTATED OPERATING AGREEMENTOperating Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Delaware
REGISTRATION RIGHTS AGREEMENTRegistration Rights Agreement • August 8th, 2005 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)
This Agreement is made pursuant to the Securities Purchase Agreement, dated as of the date hereof among the Company and the Purchasers (the “Purchase Agreement”).
Exhibit 10.28.4 AMENDED AND RESTATED SECURITY AGREEMENT THIS AMENDED AND RESTATED SECURITY AGREEMENT dated as of December 28, 1998 (this "Agreement") among GENZYME CORPORATION, a Massachusetts corporation having its principal offices at One Kendall...Security Agreement • April 4th, 2000 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
ARTICLE 1 EMPLOYMENT OF EXECUTIVEExecutive Employment Agreement • March 28th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
Exhibit 10.1 SEPARATION AGREEMENT AND GENERAL RELEASE This Agreement dated as of May 16, 2001 is by and between Genzyme Transgenics Corporation ("GTC"), its predecessors, subsidiaries, successors, related and affiliated companies, assigns, officers,...Separation Agreement • August 7th, 2001 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.4 GENZYME TRANSGENICS CORPORATION CONSULTING AGREEMENT This Consulting Agreement dated as of July 1, 1998 is between James A. Geraghty (the "Consultant") and Genzyme Transgenics Corporation (the "Company"), a Delaware corporation. In...Consulting Agreement • November 12th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
RECITALSSublease Agreement • August 2nd, 2002 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
GENZYME TRANSGENICS CORPORATION FEBRUARY 6, 2001 STOCK PURCHASE AGREEMENTStock Purchase Agreement • March 13th, 2001 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Delaware
Exhibit 10.54 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of March 20, 1998, by and between GENZYME TRANSGENICS CORPORATION, a Massachusetts corporation, with headquarters located at Five Mountain...Securities Purchase Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • New York
Exhibit 10.16.4 LOAN MODIFICATION AGREEMENT This Loan Modification Agreement (this "Loan Modification Agreement") is entered into as of January 25, 2004, by and between SILICON VALLEY BANK, a California-chartered bank, with its principal place of...Loan Modification Agreement • March 8th, 2004 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)
EXHIBIT 10.28.2 FIRST AMENDMENT TO SECURITY AGREEMENT This FIRST AMENDMENT TO SECURITY AGREEMENT is dated as of December 15, 1997 (this "First Amendment"), by GENZYME TRANSGENICS CORPORATION, a Massachusetts corporation with its principal place of...Security Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.1 EMPLOYMENT AGREEMENT (Sandra Nusinoff Lehrman, M.D.) This Employment Agreement ("Agreement"), effective as of July 1, 1998, by and between Genzyme Transgenics Corporation (together with its affiliates and subsidiaries, "GTC"), a...Employment Agreement • August 11th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
FIFTH AMENDMENT TOTerm Loan Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.57.1 CREDIT AGREEMENTCredit Agreement • April 5th, 1999 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
AMENDMENT AGREEMENTAmendment Agreement • May 14th, 1997 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances)
Exhibit 10.28.6 THIRD AMENDMENT TO CREDIT AGREEMENT AND AMENDMENT TO REVOLVING CREDIT NOTE AND TERM NOTE Reference is hereby made to that certain Credit Agreement dated as of December 28, 1998, as amended, by and between Genzyme Transgenics...Credit Agreement • March 22nd, 2002 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
SECURITIES PURCHASE AGREEMENTSecurities Purchase Agreement • August 8th, 2005 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York
This Securities Purchase Agreement (this “Agreement”) is dated as of August 8, 2005, among GTC Biotherapeutics, Inc., a Massachusetts corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and permitted assigns, a “Purchaser” and collectively the “Purchasers”).
FOURTH AMENDMENT TO REVOLVING CREDIT AGREEMENTRevolving Credit Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.4 CONFIDENTIAL MATERIALS OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS. AMENDED AND RESTATED COLLABORATION AGREEMENTCollaboration Agreement • November 13th, 2001 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
Exhibit 10.3.2 CONFIDENTIAL MATERIALS OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS. CONFIDENTIAL DOCUMENT AMENDED AND RESTATED LICENSE AGREEMENT THIS AMENDED AND RESTATED LICENSE AGREEMENT...License Agreement • August 2nd, 2002 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
CONFIDENTIAL GTC Biotherapeutics, Inc.Placement Agent Agreement • February 11th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York
ARTICLE I INTERPRETATION AND APPLICATIONService Agreement • March 28th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
REVO BIOLOGICS, INC. FORM OF [DIRECTOR][OFFICER] INDEMNIFICATION AGREEMENTIndemnification Agreement • June 25th, 2014 • rEVO Biologics, Inc. • Biological products, (no disgnostic substances) • Delaware
This Indemnification Agreement (“Agreement”) is made as of by and between rEVO Biologics, Inc., a Delaware corporation (the “Company”), and (“Indemnitee”).
ARTICLE 1 EMPLOYMENT OF EXECUTIVEExecutive Employment Agreement • November 13th, 2001 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
12,000,000 Shares and Warrants to Purchase 7,800,000 Shares GTC BIOTHERAPEUTICS, INC. Shares of Common Stock ($.01 par value) PLACEMENT AGENT AGREEMENTPlacement Agent Agreement • July 20th, 2006 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York
This opinion is furnished to you pursuant to Section 6(d) of the Placement Agent Agreement dated July , 2006 (the “Placement Agent Agreement”) by and among GTC Biotherapeutics, Inc., a Massachusetts corporation (the “Company”), C.E. Unterberg, Towbin, LLC, Rodman & Renshaw, LLC and Oppenheimer & Co. Inc. (the “Placement Agents”), relating to the proposed sale of an aggregate of units consisting of shares (the “Shares”) of the Company’s common stock, $0.01 par value per share (the “Common Stock”) and Common Stock Purchase Warrants to purchase an aggregate of shares (the “Warrant Shares”) of Common Stock. Capitalized terms that are defined in the Placement Agent Agreement and not otherwise defined herein have the meanings set forth in the Placement Agent Agreement.
Exhibit 10.51.4 FIRST AMENDMENT TO CREDIT AGREEMENT Reference is hereby made to that certain Credit Agreement dated as of December 28, 1998, by and between Genzyme Transgenics Corporation (the "Borrower"), and Fleet National Bank ("Lender") (as...Credit Agreement • April 4th, 2000 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
FORM OF SECURITIES PURCHASE AGREEMENTSecurities Purchase Agreement • February 11th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York
This Securities Purchase Agreement (this “Agreement”) is dated as of February 7, 2008, between GTC Biotherapeutics, Inc., a Massachusetts corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).
Exhibit 1. Form of Underwriting AgreementUnderwriting Agreement • February 4th, 2000 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • New York
GTC Biotherapeutics, Inc. and , as Trustee INDENTURE Dated as of ,Indenture • May 2nd, 2007 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
INDENTURE, dated as of , , by and between GTC Biotherapeutics, Inc., a Massachusetts corporation, as Issuer (the “Company”), and , a organized under the laws of , as Trustee (the “Trustee”).
EXHIBIT 10.2 CONFIDENTIAL MATERIALS OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS. PURCHASE AGREEMENTPurchase Agreement • November 13th, 2001 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
Exhibit 10.2 CONFIDENTIAL TREATMENT GTC Biotherapeutics, Inc. has requested that the marked portions of this document be accorded confidential treatment pursuant to Rule 24b-2 promulgated under the Securities Exchange Act COLLABORATION AGREEMENTCollaboration Agreement • November 26th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts
EXHIBIT 10.52.2 PURCHASE AGREEMENTPurchase Agreement • March 27th, 1998 • Genzyme Transgenics Corp • Biological products, (no disgnostic substances) • Massachusetts
