March 12, 2002 Dr. Doros Platika Curis, Inc. 61 Moulton Street Cambridge, MA 02138 Dear Doros: Reference is made to our letter agreement dated January 28, 2002 (the "January Letter Agreement"), relating to your severance arrangements and ongoing...

                                                                   Exhibit 10.47


                                  CURIS, INC.
                               00 Xxxxxxx Xxxxxx
                              Xxxxxxxxx, XX 00000

                                                     March 12, 2002



Xx. Xxxxx Platika
Curis, Inc.
00 Xxxxxxx Xxxxxx
Xxxxxxxxx, XX  00000

Dear Doros:

     Reference is made to our letter agreement dated January 28, 2002 (the
"January Letter Agreement"), relating to your severance arrangements and ongoing
relationship with Curis, Inc. (the "Company"). This letter agreement will
confirm that, notwithstanding the provisions of the second sentence of section 1
of the January Letter Agreement, you may actively pursue other employment
opportunities, including self employment opportunities, as of the date of this
letter agreement. All other provisions of your January Letter Agreement remain
in full force and effect, and you specifically acknowledge your continued
obligations under section 6 of the January Letter Agreement relating to your
Invention and Non-Disclosure Agreement and Non-Compete and Non-Solicitation
Agreement (as defined therein).

     Please indicate your agreement to the above by countersigning this letter
agreement in the space provided below.

                                   Sincerely yours,

                                   CURIS, INC.


                                   By: /s/ Xxxxxx X. Xxxxxxx
                                       ---------------------------------------



ACKNOWLEDGED AND AGREED,

/s/ Doros Platika
------------------------------
Xx. Xxxxx Platika