0001104659-05-049845 Sample Contracts

FIRST AMENDMENT to the Collaboration, License and Supply Agreement, dated July 6, 2004 by and between Acusphere Inc. (“Acusphere”) and Nycomed Danmark ApS (“Nycomed”)
Collaboration, License and Supply Agreement • October 24th, 2005 • Acusphere Inc • Pharmaceutical preparations

This First Amendment (the “First Amendment”), effective as of October 19, 2005, is entered into by and between Acusphere and Nycomed (the “Parties”).

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