0001104659-08-042403 Sample Contracts

THIRD AMENDMENT to the Collaboration, License and Supply Agreement, dated July 6, 2004 by and between Acusphere Inc. (“Acusphere”) and Nycomed Danmark ApS (“Nycomed”)
Collaboration, License and Supply Agreement • June 26th, 2008 • Acusphere Inc • Pharmaceutical preparations

This Third Amendment (the “Third Amendment”), effective as of June 4 2008, is entered into by and between Acusphere and Nycomed (the “Parties”).

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