0001193125-10-061957 Sample Contracts

AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations

This Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Joint Filing Agreement, dated June 27, 2007, by and among Invus, L.P., Invus Public Equities, L.P., Invus Advisors, L.L.C., Invus Public Equities Advisers, LLC, Ulys, L.L.C. and Raymond Debbane.

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SUPPLEMENT TO TRANSACTION AGREEMENTS
Supplement to Transaction Agreements • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations • New York

This Supplement to Transaction Agreements (this “Supplement”) is entered into as of March 15, 2010 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

PURCHASE AGREEMENT
Purchase Agreement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations
PURCHASE AGREEMENT SUPPLEMENT
Purchase Agreement Supplement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations
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