Supplement to Transaction Agreements Sample Contracts

SUPPLEMENT TO TRANSACTION AGREEMENTS

Supplement to Transaction Agreements • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations • New York

• Contract Type
  Supplement to Transaction Agreements
• Filed
  March 19th, 2010
• Company
  Invus, L.P.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Supplement to Transaction Agreements (this “Supplement”) is entered into as of March 15, 2010 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

SUPPLEMENT NO. 2 TO TRANSACTION AGREEMENTS

Supplement to Transaction Agreements • February 24th, 2012 • Invus, L.P. • Pharmaceutical preparations • New York

• Contract Type
  Supplement to Transaction Agreements
• Filed
  February 24th, 2012
• Company
  Invus, L.P.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Supplement No. 2 to Transaction Agreements (this “Supplement”) is entered into as of February 23, 2012 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

SUPPLEMENT TO TRANSACTION AGREEMENTS

Supplement to Transaction Agreements • March 16th, 2010 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

• Contract Type
  Supplement to Transaction Agreements
• Filed
  March 16th, 2010
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Supplement to Transaction Agreements (this “Supplement”) is entered into as of March 15, 2010 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

TRANSACTION AGREEMENTS

Supplement to Transaction Agreements • February 24th, 2012 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

• Contract Type
  Supplement to Transaction Agreements
• Filed
  February 24th, 2012
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Supplement No. 2 to Transaction Agreements (this “Supplement”) is entered into as of February 23, 2012 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

SUPPLEMENT NO. 3 TO TRANSACTION AGREEMENTS

Supplement to Transaction Agreements • December 18th, 2020 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Supplement to Transaction Agreements
• Filed
  December 18th, 2020
• Company
  Lexicon Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Supplement No. 3 to Transaction Agreements (this “Supplement”) is entered into as of December 16, 2020 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).