0001193805-18-001374 Sample Contracts

AMENDED AND RESTATED DEPOSIT AGREEMENT
Deposit Agreement • November 29th, 2018 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

AMENDED AND RESTATED DEPOSIT AGREEMENT, dated as of November 4, 2011, by and among (i) Amarin Corporation plc, a company organized under the laws of England and Wales, and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America acting in its capacity as depositary, and any successor depositary hereunder (the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

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To: Citibank, N.A. – ADR Depositary 388 Greenwich Street, 14th Floor New York, NY 10013 Attention: Depositary Receipt Department Re: Corsicanto II Designated Activity Company Limited – Exchangeable Senior Notes Due 2047
Citibank,N.A./ADR • November 29th, 2018 • Pharmaceutical preparations • New York

References is made to the Amended and Restated Deposit Agreement, dated as of November 4, 2011, by and among Amarin Corporation plc, a company organized under the laws of England and Wales (the "Company"), Citibank, N.A., as depositary (the "Depositary"), and all Holders and Beneficial Owners of American Depositary Shares ("ADSs") issued thereunder (the "Deposit Agreement"). Terms used, but not otherwise defined, herein shall have the meaning ascribed to them in the Deposit Agreement.

Citibank, N.A. – ADR Department
Letter Agreement • November 29th, 2018 • Citibank,N.A./ADR • Pharmaceutical preparations

Reference is made to the Amended and Restated Deposit Agreement, dated as of November 4, 2011, as amended and supplemented from time to time (the “Amended and Restated Deposit Agreement”), by and among Amarin Corporation PLC, a company organized under the laws of England and Wales (the “Company”), Citibank, N.A., a national banking association (“Citibank”) organized and existing under the laws of the United States of America, in its capacity as Depositary (the “Depositary”), and all Holders and Beneficial Owners of American Depositary Shares (the “ADSs”) issued thereunder, as supplemented by the Restricted ADS Letter Agreement, dated July 26, 2012 (the “Restricted ADS Letter Agreement” and together with the Amended and Restated Deposit Agreement, the “Deposit Agreement”). Capitalized terms used but not otherwise defined herein shall have the meaning ascribed to them in the Deposit Agreement.

To: Citibank, N.A. – ADR Depositary 388 Greenwich Street, 14th Floor New York, NY 10013 Attention: Depositary Receipt Department Re: Amarin Corporation plc – ADSs (CUSIP No.: 023111206) & Restricted ADSs (CUSIP No.: 0231119L3)
Ads Letter Agreement • November 29th, 2018 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

Reference is made to the Amended and Restated Deposit Agreement, dated as of November 4, 2011, by and among Amarin Corporation plc, a company organized under the laws of England and Wales (the "Company"), Citibank, N.A., as Depositary (the "Depositary"), and all Holders and Beneficial Owners of American Depositary Shares ("ADSs") issued thereunder (the "Deposit Agreement"). All capitalized terms used, but not otherwise defined, herein shall have the meaning assigned thereto in the Deposit Agreement.

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