Collaborative Research Agreement and License and Royalty Agreement Sample Contracts

AMENDMENT #1 TO COLLABORATIVE RESEARCH AGREEMENT AND LICENSE AND ROYALTY AGREEMENT
Collaborative Research Agreement and License and Royalty Agreement • November 8th, 2004 • Medarex Inc • Services-commercial physical & biological research

This AMENDMENT #1 TO COLLABORATIVE RESEARCH AGREEMENT AND LICENSE AND ROYALTY AGREEMENT (“Amendment #1”) is entered into as of September 15, 2004 (the “Amendment #1 Effective Date”) by and between PFIZER INC, a Delaware corporation, having an office at 235 East 42nd Street, New York, New York 10017 (together with its Affiliates, “Pfizer”), and MEDAREX, INC., a New Jersey corporation, with a principal place of business at 707 State Road, Princeton, New Jersey 08540, and GENPHARM INTERNATIONAL, INC., a wholly owned subsidiary of Medarex, Inc. (Medarex, Inc. and GenPharm International, Inc., together, “Medarex”).

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