Drug Product Production and Clinical Supply Agreement Sample Contracts

Second Amendment to Drug Product Production and Clinical Supply Agreement
Drug Product Production and Clinical Supply Agreement • May 7th, 2008 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)

This Second Amendment (the “Second Amendment”) is entered into and effective as of March 12, 2008 (the “Second Amendment Date”) for the purpose of amending that certain Drug Product Production and Clinical Supply Agreement dated August 15, 2006 by and between Altus Pharmaceuticals Inc., a Delaware corporation (“Altus”), and Althea Technologies, Inc., a Delaware corporation (“Althea”), as amended by that certain First Amendment to Drug Product Production and Clinical Supply Agreement dated June 25, 2007 (collectively, the “Agreement”). Capitalized terms used but not otherwise defined herein shall have the meanings provided in the Agreement.

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First Amendment to Drug Product Production and Clinical Supply Agreement
Drug Product Production and Clinical Supply Agreement • August 8th, 2007 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)

This First Amendment (the “Amendment”) is entered into and effective as of June 25, 2007 (the “Amendment Date”) for the purpose of amending that certain Drug Product Production and Clinical Supply Agreement dated August 15, 2006 (the “Agreement”) by and between Altus Pharmaceuticals Inc., a Delaware corporation (“Altus”), and Althea Technologies, Inc., a Delaware corporation (“Althea”). Capitalized terms used but not otherwise defined herein shall have the meanings provided in the Agreement.

ARTICLE 1 DEFINITIONS.
Drug Product Production and Clinical Supply Agreement • November 14th, 2006 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)
Third Amendment to Drug Product Production and Clinical Supply Agreement
Drug Product Production and Clinical Supply Agreement • March 11th, 2009 • Altus Pharmaceuticals Inc. • Biological products, (no disgnostic substances)

This Third Amendment (the “Third Amendment”) is entered into and effective as of November 25, 2008 (the “Third Amendment Date”) by and between Altus Pharmaceuticals Inc., a Delaware corporation (“Altus”), and Althea Technologies, Inc., a Delaware corporation (“Althea”).

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