Hedgehog Pathway definition

Hedgehog Pathway means either or both (as the case may be) (a) the Hedgehog protein family or (b) the signaling pathway activated by an extracellular ligand of the Hedgehog protein family.
Hedgehog Pathway. Hedgehog Pathway shall mean all of the following members of the Hedgehog cell-signaling pathway: (i) all hedgehog ligands (Sonic, Indian, Desert) and transmembrane transport-like proteins, like Disp1 or Disp2, involved in the secretion of the HH ligand, (ii) Smoothened (Smo), including alternatively spliced forms and Smo with activating mutations, (iii) all Gli transcription factors (Gli 1, 2, 3), (iv) mutated or unmutated Patched (Ptch) receptor 1 and 2, (v) Cdo, Cdon and Xxx (brother of Cdo), (vi) Suppressor of Fused (SuFu), (vii) Cdc2l1 kinase, (viii) Hedgehog interacting protein (HHIP), and (ix) ARL13B.
Hedgehog Pathway is as defined in the Hedgehog Agreement.

Examples of Hedgehog Pathway in a sentence

  • Curis and Genentech desire to enter into a collaborative relationship for research, discovery and development activities using Curis’ Hedgehog Pathway technologies and for the development and commercialization of human therapeutic products resulting from such activities.

  • See A Randomized, Phase II Multicenter Trial Evaluating the Efficacy and Safety of a Systemic Hedgehog Pathway Antagonist (GDC-0449) in Patients With Basal Cell Nevus Syndrome (BCNS), ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/results/NCT00957229 (primary completion date January 2014) (last updated June 6, 2016).

  • A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma.

  • Correlations between the Sonic Hedgehog Pathway and basal cell carcinoma.

  • Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation.

  • Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.

  • Chapter Twenty-Six - Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes.

  • Sonic Hedgehog Pathway as a Target for Therapy in Angiogenesis-Related Dis- eases.

  • Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy.

  • In addition, our collaborators have continued to advance our partnered assets, including Genentech’s testing of Hedgehog Pathway Inhibitor GDC-0449 in three Phase II clinical studies and Debiopharm’s Phase I testing of Heat Shock Protein 90 inhibitor Debio 0932.


More Definitions of Hedgehog Pathway

Hedgehog Pathway means the biological signaling cascade which stimulates the transcription of various genes that mediate Hedgehog-dependent phenotypic cellular changes, as evidenced by the upregulation of transcription of Gli.
Hedgehog Pathway shall have the meaning ascribed to the term in the License Agreement.
Hedgehog Pathway means the [**] Hedgehog[**] as evidenced by the [**]
Hedgehog Pathway. Hedgehog Pathway shall mean all of the following members of the Hedgehog cell-signaling pathway: (i) all hedgehog ligands (Sonic, Indian, Desert) and transmembrane transport-like proteins, like Disp1 or Disp2, involved in the secretion

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