Cangrelor Sample Clauses

Cangrelor. Cangrelor is a direct acting reversible platelet P2Y12 inhibitor. Unlike the previously described agents, cangrelor is administered intravenously with its effect rapidly reversed following end of the infusion. Similar to prasugrel and ticagrelor, cangrelor is characterized by a rapid onset of action and more effective platelet inhibition compared to clopidogrel, with a favorable safety profile concluded from the initial phase II trials. Cangrelor underwent two phase III clinical trials, the “Clinical Trial to Demonstrate the Efficacy of Cangrelor (PCI)”221, 222 and the “Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition (Platform)”223 that were discontinued due to insufficient evidence of cangrelor’s clinical ef- fectiveness. Cangrelor is still being studied as a bridge for patients on clopidogrel who are planned for CABG operation (BRIDGE: Maintenance of Platelet inihiBition With cangRelor After dIscontinuation of ThienopyriDines in Patients Undergoing surgery)224.
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Cangrelor. Cangrelor is a novel P2Y12 inhibitor that, like ticagrelor, binds directly to the receptor and induces reversible blockade. The drug is a non-thienopyridine adenosine triphosphate analogue that is administered intravenously and has shown promising results in clinical trials to date 129. The drug has a rapid onset and offset of action, reaches steady state within a few minutes, and achieves greater than 90 % inhibition of platelet activation resulting from the P2Y12 pathway 130. In a series of randomised-controlled studies, when compared with current standard therapy, however, no significant differences in mortality or further MI were observed when patients were treated with either clopidogrel or cangrelor before 131 or during PCI 132. A double-blind placebo- controlled trial involving 11,145 patients subsequently found that cangrelor significantly reduced the rate of ischemic events during PCI, with no increase in severe bleeding, compared with clopidogrel 133. At present, cangrelor has been approved by US and European regulatory agencies for use in patients undergoing PCI, although it has not yet been recommended by the National Institute for Health and Care Excellence (NICE) for use in the UK due to a relative lack of clear data 134 135
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