Central blood pressure (CBP) Sample Clauses

Central blood pressure (CBP). Brachial SBP (bSBP) and DBP (bDBP) measurements are the current gold standard for the diagnosis of hypertension.46 Over the past decade emerging epidemiological data suggests that central measures of blood pressure and other CBP waveform indices taken from either invasively measured or non-invasively derived aortic blood pressure waveform have an independent predictive value in cardiovascular risk assessment.47 Whether CBP indices have unquestionable advantages over brachial measurements is less clear. The 2013 ESH guideline does not recommend routine measurement of central haemodynamic indices in clinical practice, except for a potential role in assessing ISH in young patients. However it acknowledges their fundamental role in aiding the understanding of the haemodynamic mechanisms and therapeutics of hypertension.10 CBP indices are potentially important in the study of pulsatile haemodynamics because central pulse pressure (cPP) is what vital organs such as the brain, the heart and the kidney are exposed to not bPP.18, 48, 49 Since pulse pressure amplification may vary between subjects the assessment of central pulsatility by bPP may be inaccurate.48, 50 Furthermore, different classes of anti-hypertensive drugs appear to have differential effects on central and peripheral blood pressure measurements with consequent impact on outcomes favouring regimes that preferentially reduce CBP.19, 51-55
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