End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 EPublished on 27 June 2013. Downloaded by Radboud University Nijmegen on 9/5/2022 10:50:53 AM. Soft Matter PAPER Cite this: Soft Matter, 2013, 9, 10493 Received 26th April 2013 Accepted 27th June 2013 DOI: 10.1039/c3sm51163d xxx.xxx.xxx/xxxxxxxxxx Self-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array organization of the Xxxxxx bacterial cell-division protein FtsZ in confined environments† Xxxxx ObservatoryXxxxxxxx,‡a Begon~a Xxxxxxxxxx,‡b Xxxxxxxxxx Xxx Xxxxxxxx,a Esra xx Xxxxxx,a Xxxxxxxxxxxxx Xxxxxxxxxxxx,a Germa´n Xxxxx§*b and Xxxxxxx X. X. Xxxx§*a We report a microfluidic approach to generate aqueous droplets in oil of different dimensionality, stabilized by a lipid monolayer, to systematically probe the polymerization of bacterial cell-division protein FtsZ into fibrous networks as a function of the concentrations of crowding agent, FtsZ, and GTP. The identification is efficiently performed for neutrinos FtsZ bundles confined in droplets were dynamic, and their distribution depended on the intrinsic properties of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to system and restrictions imposed by the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–spatial boundaries.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology Instrumentation Calibration of the logarithmic-periodic dipole Observatory using an octocopter To cite this article: A. Aab et al 2017 JINST 12 T10005 View the article online for updates and Astroparticle Physics JCAP10(2019)022 Eenhancements. You may also like - ATLAS data quality operations and performance for 2015–2018 data-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19taking antenna (LPDA) radio stations at the Xxxxxx Xxxxx G. Xxx, 2019 Accepted September 5X. Abbott, 2019 Published October 8, 2019 AbstractX.X. Xxxxxx et al. Neutrinos with energies above 1017 eV are detectable with - Impact of atmospheric effects on the Surface Detec- tor Array energy reconstruction of air showers observed by the surface detectors of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Published on 11 October 2018. Downloaded on 9/4/2019 8:20:33 AM. FRONTIERS RESEARCH ARTICLE Cite this: Mater. Chem. Front., 2018, 2, 2263 Received 31st July 2018, Accepted 10th October 2018 DOI: 10.1039/c8qm00375k xxx.xx/xxxxxxxxx-xxxxxxxxx Wavelength dependent nonlinear optical response of Cosmology tetraphenylethene aggregation-induced emission luminogens† Xxxxxx Xxxxx,a Xxxxxx Xx,bc Xxxxxxxx Xxxx,b Xxxxxx Xxxxx,x Xxxxxxxx Xxx,a Xxxxxxxx Xx,*a Xxxx Xxxxxxx and Astroparticle Physics JCAP10(2019)022 EXxxx-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with Xx Xx *ad Since the Surface Detec- tor Array discovery of the Xxxxxx Xxxxx Observatorystriking aggregation-induced emission (AIE) phenomenon, tremendous efforts have been devoted to the exploration of brilliant organic solid-state light emitting materials and their underlying mechanistic theories. While AIE is well established in linear optics, the nonlinear optical (NLO) properties of the AIE luminogens (AIEgens) remain relatively unexplored. Here, we present a detailed study of the NLO properties of crystalline prototypical AIEgens based on tetraphenylethene (TPE). The identification results disclose a highly efficient NLO response of TPE crystals which is efficiently performed for neutrinos strongly dependent on the wavelength of all flavors interacting in the atmosphere incident near infrared (NIR) light. TPE exhibits mainly two-photon excited fluorescence (TPF) upon excitation at large zenith angles700 nm o l o 800 nm, as well as for Earthwhile it exhibits three-skimming τ neutrinos with nearly tangential trajectories relative to the Earthphoton excited fluorescence (3PF) if pumped at 800 nm o l o 840 nm. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxFor pump wavelengths longer than 840 nm, mainly second harmonic generation (SHG) is observed. The 90% C.L. single-flavor limit introduction of halogen atoms into the TPE backbone results in comparable NLO hyperpolarizabilities, but allows for future derivations and functionalizations. The exploration of the nonlinear optical properties of AIEgens might open a new avenue to the diffuse flux a next generation of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–multifunctional organic and composite photonic materials and devices.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos Search for photons with energies above 1017 1018 eV are detectable with using the Surface Detec- tor Array hybrid detector of the Xxxxxx Xxxxx Observatory To cite this article: X. Xxx et al JCAP04(2017)009 You may also like - ATLAS data quality operations and performance for 2015–2018 data-taking X. Xxx, X. Xxxxxx, X.X. Xxxxxx et al. - Impact of atmospheric effects on the energy reconstruction of air showers observed by the surface detectors of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Published on 05 January 2018. Downloaded by Radboud University Nijmegen on 2/21/2020 3:54:43 PM. PCCP PAPER Cite this: Phys. Chem. Chem. Phys., 2018, 20, 4067 Received 28th November 2017, Accepted 5th January 2018 DOI: 10.1039/c7cp07975c xxx.xx/xxxx Guanidinium/ammonium competition and proton transfer in the interaction of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable the amino acid arginine with the Surface Detec- tor Array tetracarboxylic 18-crown-6 ionophore† Xxxx Xxxx´n Xxxxx´s-Xxxxxx, a Xxxx Xxxxxx, b Xxx Xxxxxx b and Xxxxx Mart´xxxx-Xxxx *a 3 The recognition of arginine plays a central role in modern proteomics and genomics. Arginine is unique among natural amino acids due to the high basicity of its guanidinium side chain, which sustains specific interactions and proton exchange biochemical processes. The search for suitable macrocyclic iono- phores constitutes a promising route towards the development of arginine receptors. This study evaluates the conformational features involved in the binding of free arginine by the polyether macrocycle (18-crown-6)-tetracarboxylic acid. Infrared action vibrational spectroscopy and quantum- chemical computations are combined to characterize the complexes with net charges +1 and +2. The spectrum of the Xxxxxx Xxxxx Observatory+1 complex can be explained in terms of a configuration predominantly stabilized by a robust bidentate coordination of guanidinium with a carboxylate group formed from the deprotonation of one side group of the crown ether. The identification released proton is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative transferred to the Earthamino terminus of arginine, which then coordinates with the crown ether ring. No neutrino candidates were found in ∼ 14.7 years In an alternative type of data taken up to 31 August 2018conformation, partly consistent with experiment, the amino terminus is neutral and the guanidinium group inserts into the crown ether cavity. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to In the diffuse flux +2 complexes, arginine is always doubly protonated and the most stable conformations are characterized by a tripodal coordination of ultra-high-energy neutrinos the ammonium –NH + group of arginine with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–oxygen atoms of the macrocycle ring, while the interactions of the amino acid with the side carboxylic acid groups of the crown ether acquire a remarkable lesser role.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 JCAP06(2020)017 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19April 23, 2019 2020 Accepted September May 5, 2019 2020 Published October June 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array 2020 ArXiv ePrint: 2004.10591 ⃝c 2020 IOP Publishing Ltd and Sissa Medialab xxxxx://xxx.xxx/10.1088/1475-7516/2020/06/017 JCAP06(2020)017 3 Methods 3 3.1 Multiplets 3 3.2 Thrust ratio 4 4 Target selection and benchmark simulation 4 4.1 Target selection 5 4.2 Benchmark simulation 6 5 Sensitivity studies 8 5.1 Sensitivity of the Xxxxxx Xxxxx Observatory. multiplets method 8 5.2 Sensitivity of the thrust method 11 A Thrust ratio: p-value calculation for the all-sky blind search 18 1 Introduction The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux sources of ultra-high-energy neutrinos with an Eν−2 spectrum cosmic rays (UHECRs) is one of the main unsolved challenges in astrophysics. Since UHECRs are charged particles, their path from their sources to Earth is modified by the extragalactic and Galactic magnetic fields they traverse, most notably by the latter. The knowledge of these intervening fields is still poor, despite the considerable experimental effort in the area (see e.g. [1–3] and references therein). Another element that makes the magnetic deflections difficult to predict is the uncertain composition of UHECRs. This is due to the fact that measurements of the maximum of the shower development, which depends on the mass of the primary particle, have low statistics at the highest energies and its interpretation depends on the modelling of the hadronic inter- actions. The results from the Xxxxxx Xxxxx Observatory [4–6] indicate that the composition becomes heavier with increasing energy. However, measurements do not rule out a light nu- clei fraction at the highest energies, which might originate in a few nearby sources, different from the average ones. In such a case, the search for magnetically-induced signatures in the arrival directions of UHECRs could help identify this type of sources. Several analysis techniques have been designed to capture this kind of effect, including indirect ways such as in [7]. In this work, we show the results of two different methods applied to perform this search in a direct way, which are referred to as “multiplets” and “thrust”. Multiplets are defined as a set of events that show a correlation between their arrival direction and the inverse of their energy, which is expected if they come from the same source, they have the same electric charge and their deflections are small and remain coherent. The observation of multiplets could enable the accurate identification of the direction of the source and could also provide a new means to probe the Galactic magnetic field by inferring the value of its integrated component orthogonal to the trajectory of cosmic rays. JCAP06(2020)017 A search for multiplets was performed by the Xxxxxx Xxxxx collaboration in [8]. In that work, data up to 31st December 2010 were used, which amounted to a total exposure of 25,800 km2 sr yr. The results obtained were not statistically significant. The largest multiplet found above 20 EeV had 12 events and the probability that it would appear by chance in an isotropic distribution of events was 6%. There were also two independent 10-plets and the chance probability of having at least three multiplets with a multiplicity equal to or larger than 10 was 20%. With the larger dataset used in this work, the number of events added to these multiplets is not statistically significant when comparing it to the number of events that would be added if the arrival directions were isotropic, with a p-value of 60.5%. In the thrust method, an observable is built from a principal axis analysis in a localized region of the sky, measuring the elongation of a pattern with respect to the center of the region of interest (ROI). The thrust method was applied to data by the Xxxxxx Xxxxx collab- oration in [9], with events detected up to 19th March 2013, amounting to a total exposure of 32,800 km2 sr yr. The measured distributions of the thrust observables with the centroid corresponding to the highest energy range 1.0 × 1017 eV–cosmic rays did not reveal any local patterns in the arrival directions of UHECRs. In this work, we update these analyses with more statistics. The data set used, which amounts to a total exposure of 101,900 km2 sr yr, is described in section 2. This is an increase of a factor 4 with respect to [8] and a factor 3 with respect to [9]. The methods used are discussed in detail in section 3. Their expected sensitivity is shown in section 5, using a benchmark simulation described in section 4. The methods are applied to a targeted search on a selection of nearby active galactic nuclei (AGNs) and starburst galaxies (SBGs), candidates to be sites of ultra-high-energy (UHE) acceleration, and the results are presented in section 6. Moreover, in section 7, we apply the methods to an all-sky blind search. Finally, in section 8, we present our conclusions.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal International Edition: DOI: 10.1002/anie.201808085 German Edition: DOI: 10.1002/ange.201808085 Nucleophilic versus Electrophilic Reactivity of Cosmology Bioinspired Superoxido Nickel(II) Complexes Xxxxxxxxx Xxxxx+, Xxxxxxx Xxxxxxx+, Xxxxxx Xxxxxx, Xxxx Xxxxxx, Xxxxxxx Xxxxxx, Xxxxxxxx Xxxxx, Xxxx Xxxxxxxxxxx, Xxxxxx Xxxxxxxx, Xxxx X. Xxxxxxxx, Xxxx Xxxxxxxx,* Xxxxxxx Xxxxxxxxx,* Xxxxxxxx Xxxxxx,* and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Xxx*
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 Exxxxxx. De vermeende feitelijk bestuurder ont- springt de dans nu Esma xx xxxxxx heeft aange- voerd om vast xx xxxxxx stellen dat deze per- soon feitelijk beleidsbepaler was. mr. L.J.J. Kerstens xxxxxxxx bij Rutgers & Xxxxx NV te Amsterdam 274 Xxxx Xxxx 23 juni 2023, nr. 21/04233, o(CEncl.A-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19GRank-Berenschot,ECLI:NL:PHR:2022:1077,xxxxxxxxxxxxxxxx.xxx.xx) CLI:NL:HR:2023:970 (xx. Xxxxxx, 2019 Accepted September 5mr. Xxxxx-xxx xxx Xxxxx, 2019 Published October 8xx. Xxxxxxxxxxx, 2019 Abstractmr. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx ObservatoryXxx Xxxxx, mr. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith anglesMakkink) (Concl. A-G Rank-Berenschot, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the EarthECLI:NL:PHR:2022:1077, te vinden op opmaat. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018xxx.xx) Noot prof. This leads to restrictive upper bounds on their fluxxx. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–X.X. Xxxxxxx
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Correspondence Xxxx X. Xx x.xx@xxxxxxx.xx.xx Received June 19, 2019 3 September 2010 Revised 9 November 2010 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array 10 November 2010 Physiological role of the respiratory quinol oxidase in the anaerobic nitrite-reducing methanotroph ‘Candidatus Methylomirabilis oxyfera’ Xxxx X. Xx,1 Xxxxx xx Xxxxx,2 Xxxx X. xxx Xxxx,1 Xxxxxxxx X. Xxxxxx,13 Xxxx X. X. Op den Camp,1 Xxx X. Keltjens,1 Xxxx X. X. Jetten1,2 and Marc Strous1,3,4 1Department of Microbiology, Institute of Wetland and Water Research (IWWR), Radboud University Nijmegen, Xxxxxxxxxxxxx 000, 0000 XX Xxxxxxxx, Xxx Xxxxxxxxxxx 2Department of Biotechnology, Delft University of Technology, Xxxxxxxxxxx 00, 0000 XX Xxxxx, Xxx Xxxxxxxxxxx 3Max Xxxxxx Xxxxx ObservatoryInstitute for Marine Microbiology, Xxxxxxxxxx. 0, X-00000 Xxxxxx, Xxxxxxx 4Centre for Biotechnology, University of Bielefeld, Postfach 10 01 31, D-33501 Bielefeld, Germany The anaerobic nitrite-reducing methanotroph ‘Candidatus Methylomirabilis oxyfera’ (‘Ca. M. oxyfera’) produces oxygen from nitrite by a novel pathway. The identification major part of the O2 is efficiently performed used for neutrinos methane activation and oxidation, which proceeds by the route well known for aerobic methanotrophs. Residual oxygen may serve other purposes, such as respiration. We have found that the genome of ‘Ca. M. oxyfera’ harbours four sets of genes encoding terminal respiratory oxidases: two cytochrome c oxidases, a third putative bo-type ubiquinol oxidase, and a cyanide- insensitive alternative oxidase. Illumina sequencing of reverse-transcribed total community RNA and quantitative real-time RT-PCR showed that all flavors interacting four sets of genes were transcribed, albeit at low levels. Oxygen-uptake and inhibition experiments, UV–visible absorption spectral characteristics and EPR spectroscopy of solubilized membranes showed that only one of the four oxidases is functionally produced by ‘Ca. M. oxyfera’, notably the membrane-bound bo-type terminal oxidase. These findings open a new role for terminal respiratory oxidases in anaerobic systems, and are an additional indication of the atmosphere at large zenith anglesflexibility of terminal oxidases, as well as for Earthof which the distribution among anaerobic micro-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–organisms may be largely underestimated.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology 9th Workshop on Speech and Astroparticle Physics JCAP10(2019)022 ELanguage Technology in Education (SLaTE) 18-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 1920 August 2023, 2019 Accepted September 5Dublin, 2019 Published October 8Ireland Simone Wills1, 2019 AbstractXxxxxxxx Xxxxxxx-Garc´ıa1, Catia Cucchiarini1, Xxxxxx Strik1 1Radboud University Nijmegen, The Netherlands xxxxxx.xxxxx@xx.xx, xxxxxxxx.xxxxxxxxxxxxx@xx.xx, xxxxx.xxxxxxxxxxx@xx.xx, xxxxxx.xxxxx@xx.xx With recent advancements in automatic speech recognition (ASR), ASR-based educational applications have become in- creasingly viable. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array This paper presents a preliminary investiga- tion into whether peer evaluations of the Xxxxxx Xxxxx Observatoryspeech produced dur- ing the use of these applications, by primary school-aged chil- dren, is reliable and valid. Twenty-one Dutch primary school children assessed non-native read speech in terms of intelligi- bility, accuracy, and reading performance. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angleschildren’s judge- ments were compared to those made by adult Dutch speakers, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years performance of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxthe Whisper ASR system. The 90% C.L. singlechildren proved to be reliable raters with agreement levels en par with the adult group, with findings indicating that primary school-flavor limit to aged children can provide peer evaluation of speech suit- able for enhancing the diffuse flux of ultrafeedback provided by ASR-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–based lan- guage learning applications.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology Markus Klinik1(✉), Xxxxxxx van Gastel1,2, Xxxxxxx Kop1, and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19Marko van Eekelen1,2 1 Radboud University, 2019 Accepted September 5Nijmegen, 2019 Published October 8, 2019 The Netherlands {M.Klinik,X.xxxXxxxxx,X.Xxx,Xxxxx}@xx.xx.xx 2 {Xxxxxxx.xxxXxxxxx,Xxxxx.xxxXxxxxxx}@xx.xx Abstract. Neutrinos with energies above 1017 eV are detectable with Energy consumption in embedded systems plays a large role as it has implications for the Surface Detec- tor Array power supply and the batteries used. Pro- grammers of the Xxxxxx Xxxxx Observatorythese systems should consider how their programs control external devices, and where energy consumption hotspots lie. The identification is efficiently performed for neutrinos We present a static analysis to predict and visualize energy consumption of all flavors interacting external devices controlled by programs written in a simple imperative program- ming language. Currently available energy consumption analysis tech- niques generate graphs over time, which makes it difficult to see from where in the atmosphere at large zenith anglessource code the consumption originates. Our method gen- erates graphs over source locations, called skyline diagrams, showing the maximum power draw for each line of source code. Our method harnesses symbolic execution extended with support for controlling external devices. This gives accurate predictions and com- plete code path coverage, as well far as for Earth-skimming τ neutrinos the limits of computability allow. To make the diagrams easier to understand, we introduce a merge algo- rithm that condenses all skylines into a concise overview. We demonstrate the potential by analysing various example programs with nearly tangential trajectories relative our prototype implementation. We envision this approach being used to identify energy consumption hotspots of embedded systems during the Earthdesign and devel- opment phase, in a less involved way than traditional approaches. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Keywords: Symbolic execution · Program analysis · Energy use
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 Published in JCAP as DOI: 10.1088/1475-7516/2019/11/004 arXiv:1906.07419v2 [astro-ph.HE] 8 Nov 2019 Observatorio Xxxxxx Xxxxx, Malargu¨e, Argentina E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with With the Surface Detec- tor Array Detector array (SD) of the Xxxxxx Xxxxx ObservatoryObservatory we can detect neutrinos with energy between 1017 eV and 1020 eV from point-like sources across the sky, from close to the Southern Celestial Pole up to 60◦ in declination, with peak sensitiv- ities at declinations around ∼ −53◦ and ∼ +55◦, and an unmatched sensitivity for arrival directions in the Northern hemisphere. The identification is efficiently A search has been performed for highly-inclined air showers induced by neutrinos of all flavors interacting flavours with no candidate events found in data taken between 1 Jan 2004 and 31 Aug 2018. Upper limits on the atmosphere at large zenith anglesneutrino flux from point-like steady sources have been derived as a function of source declination. An unrivaled sensitiv- ity is achieved in searches for transient sources with emission lasting over an hour or less, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative if they occur within the field of view corresponding to the Earth. No neutrino candidates were found in ∼ 14.7 years zenith angle range between 60◦ and 95◦ where the SD of data taken up the Xxxxxx Xxxxx Observatory is most sensitive to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–neutrinos.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Psychophysiology, 40 (2003), 60–68. Xxxxxxxxx Publishing Inc. Printed in the USA. Copyright Ⓒ 2003 Society for Psychophysiological Research Auditory event-related potentials in humans and rats: Effects of Cosmology task manipulation XXXX XXXXXXX, J. H. R. XXXX, XXXXXX XXX LUIJTELAAR, XXXXXXXX X. X. XXXXXXXXX, MARIJTJE X. X. XXXXXXX, AND XXXXXXXXXX X. XXX XXXX Nijmegen Institute of Cognition and Astroparticle Physics JCAP10(2019)022 Information/Department of Biological Psychology, University of Nijmegen, Nijmegen, The Netherlands Abstract The purpose of this study was to compare components of the rat and human auditory event-related potential (ERP) as generated in active oddball and passive single-stimulus tasks. The rats were trained to discriminate between target and standard stimuli in an oddball task, whereas the human subjects received instructions. Task effects on various ERP components were found in both species. Interestingly, effects on the P3 component were similar in the species with regard to amplitude: Target stimuli elicited a higher amplitude in the oddball task than did standard stimuli. This might indicate that the P3 shares the same characteristics between species. However, the first four components occurred 1.82 times earlier in rats than in humans, expecting a P3 of about 200 ms in rats. The P3 in rats appeared at 380 ms. We conclude that either the relation between human and rat peak latencies is not linear, or the P3 in rats is not the equivalent of the human P3. Descriptors: Auditory event-related potential, P3, Oddball task, Human, Rat Event-related potentials (ERPs) are averaged electroencephalo- graphical potentials triggered by, and time-locked to, sensory stimuli (Na¨ a¨ ta¨ nen, 1990). These potentials consist of various components that are either defined by polarity and order of occurrence (e.g., N2 is the second negative component), or by polarity and latency (e.g., P300 is a positive component approximately 300 ms after stimulus onset). ERPs can be used to study information processes. Numerous ERP studies have been performed in humans, often in a so-called oddball paradigm. Frequently occurring standard stimuli are interspersed with infrequently occurring target stimuli, and subjects are instructed to count targets or to press a button after the presentation of the target stimulus. Both the N1, which is suggested to be involved in attention processes (Garcı´a-Larrea, Xxxxxxxxxxx, & Xxxxxxx` re, 1992; Na¨ a¨ ta¨ nen, 1990), and the P3, which is involved in stimulus evaluation (Xxxxxxx, 1981), usually have a larger amplitude for target than for standard stimuli (Xxxxxxx, Xxxxxxx, & Xxxxxxxxx, 1987; Xxxxx & Xxxxxx, 2000; Xxxxxxxxx et al., 1996). The latencies of the N1 and P3 are generally longer at target in comparison to standard stimuli or to stimuli in a passive paradigm requiring no response (Xxxxxx & Xxxxxxx, 1990; Xxxxxxx & Xxxxxx, 1997). In addition, ERP studies have been performed in nonhuman species (Molna´ r, 1994). Monkeys (Xxxxxx, Xxxxxx, Xxxxxxxx, & Xxxxx-Xxxxxxx, 1986; Xxxxxx, XxXxxxxx, Xxxxxxxx, Xxxxxxx, & Xxxx, 1992), cats (Bas,xx-Xxxxxx, Xxx,ar, & Xxxxxxxxx, 1991; Xxxxxxxx, Xxxxxxxx, Xxxx, Xxxxx, & Xxxxxxx, 1988), and xxxxxxx (Xxxx, Xxxxxxxxx, Xxxxx, & Xxxxxxxxx, 1998) all show a component in the cortical EEG that resembles the human P3 with respect to latency. Although a component (250–500 ms) that is somewhat similar to the human P3 with respect to latency has also been found in rats (Brankacˇ k, Xxxxxxxxxxxx, & Mu¨ ller- Ga¨ rtner, 1996; Xxxxxx, Xxxxxx, Xxxxxxx, & Xxxxx, 1994; Xxxxxxx, Xxxxx, & Xxxxxxxxxxx, 1987; Xxxx, Xxxxxxxx, & Xxxxxx, 1995; Xxxxxx, 1999), others proposed that an earlier component (220–240 ms) might be considered as the equivalent of the P3 in the rat (Galicia et al., 2000; Xxxxxxxxx, Globus, & Xxxxxx, 1993). Latency alone however is not sufficient for suggesting equivalence of the P3 between rats and humans. Besides latencies, there are other uncertainties with respect to the P3 in rats. Much less work has been performed in rats than in humans. Its sensitivity to task manipulations is hardly described, and the Xxxxxx xxx Xxxxxxx, Xxxxxx Xxxxx, Xxxx Xxxxxxx, Xxxx-Xxxx Xxxxxxx, Xxxx Xxxxxxx-xxx Xxxx, Francien van de Pol, and Xxxxx Xxxxx are thanked for their (bio)technical support. Prof. dr. A. M. L. Xxxxxx is greatly acknowledged for making this study possible. Address reprint requests to: X. X. xxx Xxxx, MD, PhD, NICI/ University of Nijmegen, Xxxxxxxxxxxxxx 0, Xxxxxxx 0000, 0000 XX Xxxxxxxx, Xxx Xxxxxxxxxxx. E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19xxxx@xxxx.xxx.xx. (Xxxxxxxˇ k et al., 2019 Accepted September 51996; Xxxxxxx et al., 2019 Published October 81987; Xxxx et al., 2019 Abstract1995). Neutrinos with energies above 1017 eV are detectable with This is important because amplitudes of earlier components might influence the Surface Detec- tor Array amplitude of the P3. A final point to bear in mind is the expected latency of components. As noted, some authors suggest that the latency of the P3 is the same in rats and humans (Brankacˇ k et al., 60 1996; Xxxxxx Xxxxx Observatoryet al., 1994; Xxxxxx, 1999). However, the brain of rats is much smaller than that of humans. Therefore the conduction of a signal is faster, which should result in shorter latencies of components in rats compared to humans. This might imply that the P3 in rats, as found in some earlier studies, might not be the equivalent of the human P3 (Jodo et al., 1995; Xxxxxx, 1997; Xxxxxxxxx et al., 1993), but merely a reflection of some other late cognitive process. Direct comparisons between the human and rat ERP were not made until now, although comparative studies form the basis for the search for the nonhuman equivalent of the human ERP, particularly the P3. These studies are important, as such research may constitute a necessary basis for the establishment of neurophysiological substrata of cognitive processes. ERPs, as obtained in different species with an oddball paradigm, can be compared on similarities and differences in, for example, topographical localization, influence of task manipulation, and effects of drugs. One may have an argument for their equivalence if the components of the ERP in different species react in the same way in those species. The identification is efficiently performed for neutrinos present experiments assess the effects of all flavors interacting in task manipula- tion on the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years ERP of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxhumans and rats. The 90% C.L. singlesubjects first received auditory target and standard stimuli in an active oddball task, and, subsequently, auditory stimuli in a passive single stimulus paradigm. Methods The present experiment was part of a larger study performed at the University of Nijmegen. The effects of a drug on the ERP were investigated in a double-flavor limit to blind, placebo-controlled study in humans. In rats, silastic implants were used. Only the diffuse flux data of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–placebo groups will be reported here.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array Pieces of the Xxxxxx Xxxxx Observatorypuzzle International organizations (IOs) nowadays seem ubiquitous. It is hard to imagine any policy domain at the international level in which IOs are not involved in some way or other. The identification growing importance of IOs in global xxxxx- xxxxx, which is efficiently performed related to the rise of globalization and the end of the Cold War, has prompted students of international relations to reflect once again on their status. Rather than perceiving IOs merely as extensions of states or arenas in which to build winning coalitions, scholars increasingly view them as actors in their own right which play an ever more salient role in global politics than previ- ously envisioned (x.x. Xxxxxxx and Xxxxxxxxx 1999, 2004; Dijkzeul and Xxxxxxxxx 2003). As recent studies have aptly demonstrated, IOs can be agenda setters (x.x. Xxxxxxx 1997; Xxxxxxxx and Xxxxxxx 1998), adjudicators (Alter 2001) and teachers (Xxxxxxxxx 1996) and can affect decision-making processes (Xxxxxxxx and Xxxxxxx 2004). This edited volume builds on the growing body of literature which works on the assumption that rather than merely being the instruments of states, IOs can influence the course of international events. It seeks to determine the role of IOs in implementation processes and explores the following questions:
1 What resources do IOs have at their disposal to ensure that states follow through on their international commitments, and how effective are these? 2 How do domestic institutions, actors and political processes impede or facil- itate the efforts of IOs? Why study the role of IOs in implementation? First, states are increasingly dele- gating the implementation of international agreements and policies to IOs (Xxxxxxx et al. 2006). The World Trade Organization (WTO), for neutrinos example, has become a major player in interpreting and ensuring compliance with its rules. IOs, such as the Food and Agriculture Organization (FAO), the United Nations High Commissioner for Refugees (UNHCR) or the World Health Organization (WHO), are engaged in missions throughout the world, delivering food to those in need, preventing the spread of all flavors interacting diseases or providing shelter. The North Atlantic Treaty Organization (NATO) and the United Nations (UN) are monitor- ing and administering peace agreements in Kosovo and the Democratic Republic of Congo. The International Bank for Reconstruction and Development (IBRD, also known as World Bank), meanwhile, has launched an anti-corruption cam- paign and closely monitors both the preparation and the implementation of development-aid projects in recipient countries. Second, despite the growing involvement of IOs in implementation, we still know very little about how they do their job, what instruments they have at their disposal and which of them they use to ensure that states take action to meet their global commitments. Most of our insights stem from studies on the Euro- pean Union (EU) (x.x. Xxxxx and Xxxxxxxx 2000; Xxxxxx 2001; Xxxxxxx et al. 2005) which examine the likelihood of member states to comply with Commun- ity directives or regulations (see Mastenbroek 2005 for an overview). While these enquiries provide a valuable starting point for generating hypotheses and a baseline for comparison, they are of limited applicability. Given that the EU is the most institutionalized organization to date and equipped with exceptionally strong enforcement powers (Xxxx and Joerges 2005), including legal and xxxxx- cial penalties, findings regarding its role in implementation cannot easily be gen- eralized to include other more conventional IOs, which do not possess such tools. In addition to research on the EU, implementation has also figured in the atmosphere literature on environmental regimes (x.x. Xxxxxx et al. 1998; Xxxxx et al. 1999). However, scholars have been much more interested in the effectiveness and problem-solving capacity of such regimes (Xxxx and Xxxxxxx 2005), as opposed to examining how international agreements are translated into domestic-level policies and what specific role IOs play in this process. Third, partly owing to the paucity of empirical research, there is an ongoing debate among scholars as to how to ensure compliance with international agree- ments. While some suggest that enforcement is the only way to prevent states from reneging on internationally agreed commitments (Xxxxx et al. 1996), others, by contrast, argue that a managerial approach consisting of knowledge transfer and financial assistance will yield more satisfactory results (Xxxxxx and Xxxxxx 1993, 1995). These two approaches have hitherto been viewed as mutu- ally exclusive, so that it was either the iron fist – enforcement – or the velvet glove – management – that were assumed to prompt states to take certain actions. Recently, a third perspective has been developed which stresses IOs’ less tangible resources, such as their authority and legitimacy (e.g. Xxxxxxx and Xxxxxxxxx 1999, 2004). Yet, similarly to the previous two, we still know little about its scope conditions, that is, how and when these resources matter. This volume aims at large zenith anglesa better understanding of the role IOs play in implemen- tation by comparing a broad range of organizations in a variety of policy areas. It is the third in a series of books about IOs in a changing global environment. The first investigated the autonomy of IOs (Xxxxxxxx and Xxxxxxx 1998); the second examined decision making within them (Xxxxxxxx and Xxxxxxx 2004). The findings of the current volume are revealing in several respects. The case studies show that IOs not only use the resources at their disposal in a more flexible way than the literature suggests, but that IOs which lack strong enforce- ment tools are not necessarily any less effective than those which have these at their disposal. Furthermore, the case studies also suggest that the normative power of IOs plays a far more important role than previously assumed. Regard- ing domestic-level factors, we find that while deeply entrenched domestic insti- tutions and the opposition of powerful societal or state actors can frustrate the work of IOs, they do not necessarily paralyse them. In this introduction, we will ‘set the table’ for the subsequent chapters. Section 2 discusses the concept of implementation, distinguishing it from effec- tiveness and compliance. Drawing on different international relations approaches, in Section 3, we will identify and discuss two major factors in the literature which may empower or restrict IOs in implementation: 1 the resources of IOs 2 domestic-level factors. While the former include both enforcement measures, such as monitoring and sanctioning, and softer instruments, such as managerial skills or authority, the latter include the nature of political systems (especially mature versus new democratic states), domestic institutions and the power of societal groups, bureaucracies or civil services. Finally, Section 4 offers an overview of this volume. Traditionally, implementation has been the subject of policy and legal studies as well as public administration. Research on this subject flourished during the 1970s and 1980s but came to a halt during the last decade. Reflecting on the very latest research on implementation, Saetren (2005) lists a number of reasons for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found declining interest in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–implementation, including:
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology and Astroparticle Physics JCAP10(2019)022 EMeasurement of the average shape of longitudinal profiles of cosmic-mailray air showers at the Xxxxxx Xxxxx Observatory To cite this article: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 AbstractX. Xxx et al JCAP03(2019)018 View the article online for updates and enhancements. Neutrinos You may also like - Limits on point-like sources of ultra-high- energy neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with In the Surface Detec- tor Array Rules for the Direction of the Xxxxxx Xxxxx ObservatoryMind (Rule 12), Xxxx´ Xxxxxxxxx pokes fun at the Aristotelian definition of motion. “Who doesn’t know what motion is?,” he asks rhetorically; he then contends that motion has no need of an explanation, because each and every one of us knows what it is. In The World ch. 7, started around the same time, Xxxxxxxxx even claims that he finds the scholastic definition of motion so obscure that he is forced to leave it in “their language” – that is, motus est actus entis in potentia xxxxx in potentia est (“motion is the actuality of a thing in potentiality insofar as it is in potentiality”).1 For Xxxxxxxxx, however, and the medievals in his wake, motion was not merely an event familiar from everyday experience, but a phenomenon whose nature needed closer investigation. The identification is efficiently performed for neutrinos of all flavors interacting central place that motion occupied in medieval thought can be understood only in the atmosphere at large zenith anglescontext of Xxxxxxxxxxxx natural philoso- phy, particularly as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative it was set out in Book III of Xxxxxxxxx’s Physics and developed by medieval thinkers. This chapter will restrict itself to the Earth. No neutrino candidates were found in ∼ 14.7 years medieval discussion of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit the nature of motion – that is, it will restrict itself to the diffuse flux question ‘What is motion?’ or, more generally, ‘What is change?’ Other significant problem areas which medieval thinkers addressed include the dynamic and kinematic aspects of ultramotion – that is, motion’s relations to distance and time, and the causes of motion. In medieval terminology, these aspects concerned the study of motion “with respect to effect” (penes effectum) and “with respect to cause” (penes causam). In the latter case, some consideration was given also to the forces acting on bodies to pro- duce motions. Phenomena that fourteenth-highcentury thinkers discussed under these headings – and toward which they often took a quantitative, mathemat- ical approach – were gravity, accelerated free fall, projectile motion, and also qualitative changes in a given subject, such as heating. Because the accomplish- ments of fourteenth-energy neutrinos with an Eν−2 spectrum century scholars such as Xxxxxx Xxxxxxxxxxx, Xxxxxxx
1 For further discussion of Xxxxxxxxx’s criticism of the Aristotelian account of motion, see Xxxxxx Xxxxxx, Xxxxxxxxx’ Metaphysical Physics (Chicago: University of Chicago Press 1992) pp. 157–9. 280 Xxxxxxxx X. X. X. Thijssen Xxxxxxxxxx, Xxxxxxx Xxxxxxxxxx, Xxxxxxx Xxxxxxxxxx, and Xxxx Xxxxxxxxx (all at Oxford University’s Merton College) and Xxxx Xxxxxxx, Xxxxxx Xxxxxx, and Xxxxxx of Saxony (all at the University of Paris) on these topics have already received considerable attention in histories of science,2 however, this chapter focuses instead on what one might call the energy range 1.0 × 1017 eV–“ontological” aspects of motion.3
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Euro. Jnl of Cosmology Applied Mathematics (2018), vol. 29, pp. 1035–1061. doi:10.1017/X0000000000000000 ⃝c Cambridge University Press 2018 1035 Time adaptive numerical solution of a highly non-linear degenerate cross-diffusion system arising in multi-species biofilm modelling† MARYAM GHASEMI1, XXXXXXXX SONNER2 and Astroparticle Physics JCAP10(2019)022 EXXXXXXX X. EBERL3 1Department Applied Mathematics, University of Waterloo, Waterloo Ontario, Canada email: x00xxxxx@xxxxxxxxx.xx 2Department Mathematics, Radboud University, Nijmegen, the Netherlands email: xxxxxxxx.xxxxxx@xxx-xxxx.xx 3Department Mathematics and Statistics, University of Guelph, Guelph Ontario, Canada email: xxxxxx@xxxxxxxx.xx We propose a numerical method for the simulation of a quasi-maillinear parabolic biofilm model that exhibits three non-linear diffusion effects: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19(i) a power law degeneracy, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract(ii) a super diffusion singularity and (iii) non-linear cross-diffusion. Neutrinos with energies above 1017 eV The method is based on a spatial Finite Volume discretisation in which cross-diffusion terms are detectable with the Surface Detec- tor Array formally treated as convection terms. Time-integration of the resulting semi-discretised system is carried out using an error-controlled, time-adaptive, embedded Xxxxxxxxxx–Xxxxxx Xxxxx Observatorymethod. The identification We compare several variants of the method and two variants of the model to investigate how details such as the choice cross-diffusion coefficients, and specific variants of the time integrator affect simulation time. MSC (2010): 35K65, 65L05, 68U20, 92D25 Key words: biofilm, cross-diffusion, time-adaptivity 1 Introduction Bacterial biofilms are microbial communities attached to an immersed surface. Depending on the context, they can be formed by one or multiple species. A characteristic of biofilms is efficiently performed for neutrinos that they produce gel-like extracellular polymeric substances in which they are embedded and which offers them protection against chemical and mechanical washout and against antimicrobial agents [13, 17, 35]. Biofilms are prevalent in natural, industrial, and hospital settings. Depending on the situation, they can be harmful or beneficial. Biofilms can cause corrosion and clogging in drinking water pipelines [31]. Dental plaque, which provokes tooth decay and gum disease, is a consequence of all flavors interacting biofilm formation on teeth. Biofilm formation in the atmosphere at large zenith anglesbody can lead to failure of medical implants and This studies was financially supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) with a PGS-D scholarship awarded to MG, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative a Discovery Grant and a Research Tools and Infrastructure Grant awarded to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–HJE.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Environ Monit Assess (2020) 192: 339 xxxxx://xxx.xxx/10.1007/s10661-020-08293-3 Soils in lakes: the impact of Cosmology inundation and Astroparticle Physics JCAP10(2019)022 Estorage on surface water quality Xxx X. X. Xxxx • Xxx N. J. Xxxxxx • Xxxxx X. Xxxxxxxx • Xxxx X. X. Xxxxxx Received: 24 April 2019 / Accepted: 13 April 2020 / Published online: 7 May 2020 Ⓒ Springer Nature Switzerland AG 2020 Abstract The large-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19scale storage and inundation of contaminated soils and sediments in deep waterlogged former sand pits or in lakes have become a fairly com- mon practice in recent years. Decreasing water depth potentially promotes aquatic biodiversity, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstractbut it also poses a risk to water quality as was shown in a previous study on the impact on groundwater. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting To provide in the atmosphere at large zenith anglesurgent need for practical and robust risk indicators for the storage of terrestrial soils in surface waters, as well as for Earththe redistribution of metals and nutrients was studied in long-skimming τ neutrinos with nearly tangential trajectories relative term mesocosm experiments. For a range of sur- face water turbidity (suspended matter concentrations Electronic supplementary material The online version of this article (xxxxx://xxx.xxx/10.1007/s10661-020-08293-3) contains supplementary material, which is available to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–authorized users.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal DOI: 10.1002/JLB.MR0318-104R R E V I E W Xxxxx Xxxxxxxxx-Xxxxxx0 Xxxxx X. Xxxxx0,2,3 During the last few years, a growing body of Cosmology evidence has shown that immunological memory is not an exclusive trait of lymphocytes, as many inflammatory insults can alter the functional- ity and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array responsiveness of the Xxxxxx Xxxxx Observatoryinnate immune system in the long term. Innate immune cells, such as monocytes, macrophages, dendritic cells, and NK cells can be influenced by the encoun- ters with inflammatory stimuli, undergoing functional reprogramming and developing changed responses to subsequent chellenges. The identification is efficiently performed long-term reprogramming depends on the rewiring of cell metabolism and epigenetic processes, and they stay at the basis of induction of both innate immune memory (also termed trained immunity) and innate immune tolerance. Here, we review the central role that the effects of this long-term reprogramming of innate immune cells plays in a number of clinically relevant conditions such as vaccination, atherosclerosis, sepsis, and cancer. Innate immune system, trained immunity, metabolism, epigenetics, reprogramming, inflammation, vaccination, atherosclerosis, sepsis, cancer 1 Department of Internal Medicine and Radboud Center for neutrinos Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 2 Department for Genomics & Immunoregula- tion, Life and Medical Sciences Institute (LIMES), University of all flavors interacting in the atmosphere at large zenith anglesBonn, as well as Bonn, Germany 3 Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania Xxxxx Xxxxxxxxx-Xxxxxx, Department of Inter- nal Medicine and Radboud Center for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the EarthInfectious diseases (RCI), Radboud University Nijmegen Medical Centre, Xxxxx Xxxxxxxxxxx 0, 0000XX Xxxxxxxx, xxx Xxxxxxxxxxx. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Email: xxxxx.xxxxxxxxxxxxxxx@xxxxxxxxxx.xx
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Legitimacy and legislative priority in the Dutch edible insect sector Downloaded by [Radboud University Nijmegen] at 00:34 11 October 2017 Xxxxxx Marberg1, Xxxxxx Korzilius2 and Xxxx xxx Xxxxxxxxxx 8.1 Introduction Current global food challenges include providing food for those in greatest need, sustainable production, and reconciling the supply of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable food with the Surface Detec- tor Array demands of an increasingly wealthy population (Xxxxxxx et al., 2010). Similar concerns are voiced in The Future of Food: Scenarios for 2050 in which the researchers indicate that the key issues involved in feeding the rising global population are food security, food safety, food and health, and sustainability (Xxxxxx et al., 2010). The authors report that the rising consumption of animal products due to population and economic growth will result in an increase in greenhouse gases and a strain on resources. They differentiate between the developing world and the developed world, stating that decreasing ruminant protein production and consumption in developing countries may not be desirable given the nutritional and economic necessity of ruminant production in very poor regions. In the developed world, however, alternatives to meat could play a role in reducing environmental degradation and use of resources. As a source of protein, one of the Xxxxxx Xxxxx Observatoryalternatives to meat is insects. The identification is efficiently performed advantages of breeding insects for neutrinos protein over traditional ruminant breeding include more efficient conversion of all flavors interacting feed to food (Van Huis, 2013), fewer greenhouse gas emissions and less land degradation (Oonincx & De Boer, 2012), and high mineral and element contents (Xxxxxxx, Mangthya, & Xxxxxx, 2011; Xxxx et al., 2014). In addition to their use in food and feed, insects may also be useful in waste management (Xxxxx et al., 2014; Xxxx et al., 2015) and medicine (Cˇ erˇovský & Bém, 2014; Xxxxx-Xxxx, 2002). Regarding concerns such as allergy, microbial, parasitical and chemical hazards in the atmosphere at large zenith anglesuse of insects as food and feed, Belluco et al. (2013) found that if proper procedures are implemented, insects are a safe source of food. This is not unlike meat, fish, crustaceans and other foodstuffs which must also meet hygiene, production, processing, storage and distribution standards and be properly labeled with respect to allergens. However, Xxxxxxxxx, Vlak, Xxxxxxx-XxXxxx, Cappellozza, and Xxxxxx (2015) indicate that more research is needed on insect diseases, as well as diagnosis and control protocols. Downloaded by [Radboud University Nijmegen] at 00:34 11 October 2017 Although many researchers and edible insect advocates are positive about the potential of insects to contribute to food security and environmental sus- tainability, European policy makers are taking a cautious approach, perhaps in part due to Western attitudes towards insects. Belluco et al. (2013: 309) maintain that because the science justifies ‘insect presence in the Western diet, the greatest obstacle to consumption remains the repulsion felt by Western people’. DeFoliart (1999: 44) voiced a similar sentiment, indicating that more opportunities for Earthresearch and production would be created if the ‘Western-skimming τ neutrinos with nearly tangential trajectories relative driven stigma’ against insects as food could be redressed. Under current European Union (EU) regulations, producers may sell their insects and insect products to animal hobby markets (reptiles, birds, etc.), pet food suppliers and aquaculture. Insects and insect ingredients may not be sold as feed to livestock or on a large scale for human consumption. The sale of insects for human consumption is currently guided by Novel Food legislation which many scientists and producers consider a hindrance to the Earth. No neutrino candidates were found in ∼ 14.7 years growth of data taken up the industry and a barrier to 31 August 2018. This leads the effort to restrictive upper bounds on their fluxsolve global nutrition and food security issues (Belluco et al., 2013; IPIFF, 2015; Xxxxxxxxxx et al., 2011). The 90% C.L. single-flavor limit greatest challenges to the diffuse flux development of ultra-high-energy neutrinos with an Eν−2 spectrum the edible insect sector thus appear to be nonmarket forces – the social, political and legal arrangements that structure interactions among companies and their public. One of the key questions for producers, researchers and edible insect advocates is how to gain political priority for their issue at the EU in order to accelerate the legislation process so that the economic, social and environ- mental benefits of the sector can be realized. Despite a growing number of produ- cers worldwide, a significant increase in scholarly attention (Xxx Xxxx, 2015), and the establishment of a European lobby, advocates in the energy range 1.0 × 1017 eV–European Union indicate that the edible insect sector has had difficulty improving its legitimacy – roughly stated, its legal, social and cultural acceptance (Xxxxxxx, 1995) – with EU policy makers. In order to revise legislation and current policies, the sector will need to increase its legitimacy with the public and policy making institutions (Ju & Xxxx, 2011; Xxxxxxx, 1995; Xxx Xxxxxx et al., 2015). Gaining priority for an issue depends in large part on advocates’ ability to ‘promulgate new explanations of social reality’ and on ‘molding constituent tastes’ (Xxxxxxx, 1995: 591). All organizations in an emerging sector begin with a lack of legitimacy (Xxxxxxx & Xxxx, 1994; Stinchcombe, 1965), a situation that organizations can improve through strategic actions (Xxxxxxx & Xxxx, 1994; Xxxxxxx et al., 2010; Xxxxxxx, 1995; Xxxxxxxx & Xxxxx, 1994). Organizations can use specific nonmarket strategies as means to gain legitimacy (Xxxxxxx & Xxxx, 1999; Xxxxxxx et al., 2016; Xxxxxx, 1991). Xxxxx, Xxxx, and Xxxxxxx (2013) indicate that institutional entrepreneurs can increase legitimacy of an emerging sector by 1) identifying and publicizing problems in the current situation; 2) sug- gesting solutions based on accepted categories of expertise from other dis- ciplines; 3) emphasizing community or society benefits and playing down the benefits to themselves; 4) establishing ties to legitimate actors outside the field such as experts, academic institutions and social elites, and; 5) working with other entrepreneurs in the same field to establish social certification and a professional organization to define and defend their organizational form. Downloaded by [Radboud University Nijmegen] at 00:34 11 October 2017 Our investigation focuses on how actors in the Dutch edible insect sector can gain attention for the sector and, more specifically, identifies the legiti- macy strategy gaps in the edible insect sector as perceived by actors in the sector. A link between the Xxxxxxxx and Xxxxx (2007) framework and legiti- macy was made using Xxxxxxx’x (1995) legitimacy typology and Xxxxx et al.’s (2013) analysis of the legitimation process for institutional entrepreneurs to investigate the emerging edible insect sector in the Netherlands. In doing so, the research takes a strategic institutional approach to the way actors deal with nonmarket forces (Xxxxxxx et al., 2016; Xxxxxxx, 1995). Hence, this study shows how the combined application ocan aid in identifying perceived gaps in a sector’s legitimation process and point to favourable courses of market and nonmarket action.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Exploring the contribution of Cosmology formal and Astroparticle Physics JCAP10(2019)022 Einformal learning to academic staff member employability: A Dutch perspective Xxxxxx Van der Xxxxx Xxxxxxxx X.J.M. Xxx xxx Xxxxxxx Xx Xxxx Xxxxxxx Xxxxxxxx van Rooij To cite this document: Downloaded by RADBOUD UNIVERSITY NIJMEGAN At 04:41 08 September 2014 (PT) Xxxxxx Van der Xxxxx Xxxxxxxx X.J.M. Xxx xxx Xxxxxxx Xx Xxxx Xxxxxxx Xxxxxxxx van Rooij , (2014),"Exploring the contribution of formal and informal learning to academic staff member employability", Career Development International, Vol. 19 Iss 3 pp. 337 - 356 Permanent link to this document: Downloaded on: 08 September 2014, At: 04:41 (PT) References: this document contains references to 66 other documents. To copy this document: xxxxxxxxxxx@xxxxxxxxxxxxxx.xxx The fulltext of this document has been downloaded 36 times since 2014* Xxxxx Xxxxxxx, Xxxxxx Xxxxxxxxx, Xxxxx Xxxxxxxxx, Xxxxx Xxx Xxxxx, (2012),"Understanding work#related learning: the case of ICT workers", Journal of Workplace Learning, Vol. 24 Iss 6 pp. 416-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19429 Xxxxxxx Xxxxxxx Xxxxxxxxx, 2019 Accepted September 5Xxxxx Xxxxxxxxx, 2019 Published October 8Xxxx Xxxxxx, 2019 AbstractXxxxx Xxxxxx, (2014),"Learning to stay employable", Career Development International, Vol. Neutrinos with energies above 1017 eV 19 Iss 5 pp. 508-525 Access to this document was granted through an Emerald subscription provided by 304742 [] If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are detectable with available for all. Please visit xxx.xxxxxxxxxxxxxx.xxx/xxxxxxx for more information. Emerald is a global publisher linking research and practice to the Surface Detec- tor Array benefit of the Xxxxxx Xxxxx Observatorysociety. The identification is efficiently performed for neutrinos company manages a portfolio of all flavors interacting in the atmosphere at large zenith anglesmore than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Xxxxxxx and the LOCKSS initiative for Earth-skimming τ neutrinos with nearly tangential trajectories relative digital archive preservation. *Related content and download information correct at time of download. The current issue and full text archive of this journal is available at xxx.xxxxxxxxxxxxxx.xxx/0000-0000.xxx Downloaded by RADBOUD UNIVERSITY NIJMEGAN At 04:41 08 September 2014 (PT) Abstract Purpose – Little attention has been paid to the Earth. No neutrino candidates were found in ∼ 14.7 years employability of data taken up academic staff and the extent to 31 August 2018. This leads which continuous learning contributes to restrictive upper bounds on their fluxacademic career success. The 90% C.L. single-flavor limit purpose of this paper is to explore the diffuse flux contribution of ultra-high-energy neutrinos with an Eν−2 spectrum formal and informal learning to employability. Design/methodology/approach – Survey data were obtained from 139 academic staff members employed at the Open University in the energy range 1.0 × 1017 eV–Netherlands. The questionnaire included employee characteristics, job characteristics, organizational context factors, formal learning and informal learning and employability variables.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology and Astroparticle Physics JCAP10(2019)022 EMeasurement of the average shape of longitudinal profiles of cosmic-mailray air showers at the Xxxxxx Xxxxx Observatory To cite this article: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 AbstractA. Xxx et al JCAP03(2019)018 View the article online for updates and enhancements. Neutrinos You may also like - Limits on point-like sources of ultra-high- energy neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology Instrumentation Muon counting using silicon photomultipliers in the To cite this article: A. Xxx et al 2017 JINST 12 P03002 View the article online for updates and Astroparticle Physics JCAP10(2019)022 Eenhancements. You may also like - ATLAS data quality operations and performance for 2015–2018 data-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19taking AMIGA detector of the Xxxxxx Xxxxx observatory G. Xxx, 2019 Accepted September 5X. Abbott, 2019 Published October 8, 2019 AbstractX.X. Xxxxxx et al. Neutrinos with energies above 1017 eV are detectable with - Impact of atmospheric effects on the Surface Detec- tor Array energy reconstruction of air showers observed by the surface detectors of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal PCCP PAPER Cite this: Phys. Chem. Chem. Phys., 2021, 23, 25877 Received 17th August 2021, Accepted 4th November 2021 DOI: 10.1039/d1cp03781a xxx.xx/xxxx Infrared multiple photon dissociation action spectroscopy of Cosmology protonated unsymmetrical dimethylhydrazine and Astroparticle Physics JCAP10(2019)022 Eproton-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19bound dimers of hydrazine and unsymmetrical dimethylhydrazine† Xxxxxxxxxxx X. XxXxxx,a Xxxxx Xxxxxxxx, 2019 Accepted September 5‡a Xxxxxxxx Xxxxxxx, 2019 Published October 8b Xxxx Xxxxxx, 2019 Abstractb Xxx Xxxxxx, xx X. X. Xxxxxx,d X. X. Xxxxxxx d and X. X. Xxxxxxxxxx *a The gas-phase structures of protonated unsymmetrical 1,1-dimethylhydrazine (UDMH) and the proton- bound dimers of UDMH and hydrazine are examined by infrared multiple photon dissociation (IRMPD) action spectroscopy utilizing light generated by a free electron laser and an optical parametric oscillator laser system. Neutrinos To identify the structures present in the experimental studies, the measured IRMPD spectra are compared to spectra calculated at the B3LYP-GD3BJ/6-311+G(d,p) level of theory. These comparisons show that protonated UDMH binds the proton at the methylated nitrogen atom (a) with energies above 1017 eV are detectable two low-lying a conformers probably being populated. For (UDMH)2H+, the proton is shared between the methylated nitrogen atoms with several low-lying a conformers likely to be populated. Higher-lying conformers of (UDMH)2H+ in which the Surface Detec- tor Array proton is shared between a and b (unmethylated) nitrogen atoms cannot be ruled out on the basis of the Xxxxxx Xxxxx ObservatoryIRPMD spectrum. The identification is efficiently performed For (N2H4)2H+, there are four low-lying conformers that all reproduce the IRMPD spectrum reasonably well. As hydrazine and UDMH see usage as fuels for neutrinos rocket engines, such spectra are potentially useful as a means of all flavors interacting remotely monitoring rocket launches, especially in cases of unsuccessful launches where environmental hazards need to be assessed. Introduction Published on 05 November 2021. Downloaded by Radboud University Nijmegen on 1/4/2023 2:45:12 PM. Hydrazine (N2H4) and unsymmetrical 1,1-dimethylhydrazine (commonly known as UDMH) find applications in several areas. creating potentially toxic compounds such as methylhydroper- oxide, methyldiazene, and diazomethane.5,6 Additionally, during launch and reentry, ion–molecule reactions in the atmosphere at large zenith anglesionosphere can form protonated hydrazine, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–N H +,4 a species that can also form
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology Instrumentation Muon counting using silicon photomultipliers in the To cite this article: X. Xxx et al 2017 JINST 12 P03002 View the article online for updates and Astroparticle Physics JCAP10(2019)022 Eenhancements. You may also like - ATLAS data quality operations and performance for 2015–2018 data-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19taking AMIGA detector of the Xxxxxx Xxxxx observatory X. Xxx, 2019 Accepted September 5X. Xxxxxx, 2019 Published October 8, 2019 AbstractX.X. Xxxxxx et al. Neutrinos with energies above 1017 eV are detectable with - Impact of atmospheric effects on the Surface Detec- tor Array energy reconstruction of air showers observed by the surface detectors of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 Edoi:10.1068/c11129 Radboud University Nijmegen, Institute for Management Research, PO Box 9108, 6500 HK Nijmegen, The Netherlands; e-mail: auger xxxxxxxxxxxxx@xxxx.xxx X.Xxxxxxxxx@xx.xx.xx Wageningen University, Public Administration and Policy Group, PO Box 8130, 6700 EW Wageningen, The Netherlands; e-mail: Xxxxxx.Xxxxxxx@xxx.xx Received June 1911 May 2011; in revised form 17 February 2012 Climate change is undoubtedly one of the most urgent policy issues of our times. There is now a general recognition that climate change will occur and that nearly all countries will be affected. This is because past and current international efforts to mitigate climate change through a significant reduction of global carbon dioxide emissions are not sufficient to avoid dangerous climate change (Xxxxxxxxxx et al, 2019 Accepted September 52010). In this light, 2019 Published October 8, 2019 Abstractone of the major objectives of the International Panel on Climate Change is to study and report on vulnerability and adaptability of countries’ environment and socioeconomic systems. Neutrinos with energies above 1017 eV are detectable Climate adaptation comprises “ … all spontaneous responses and planned action taken to cope with the Surface Detec- tor Array impacts of, or reduce vulnerability to, a changing climate. Such adaptation is needed to tackle current problems or anticipate possible future changes, with the aim of reducing risk and damage cost effectively, and perhaps even exploiting potential benefits” (Xxxxx et al, 2009, page 25). In more general terms, adaptation to climate change involves adjustments of infrastructure, agriculture, urban and regional planning, and issues of nature preservation and energy supply (Xxx Xxxxxxxx et al, 2009). ¶ Corresponding author. In his classical study of the differences between management and leadership Xxxxxx (1990) argues that, where management is needed to produce orderly results efficiently, leadership is needed for realizing useful change. Since adaptation to climate change often requires a change in existing policies, practices, and institutions, this contribution departs from the view that there is a substantial need for leadership to devise and implement adaptation policies. A search of the literature in the context of adaptation to climate change(1) reveals that, first, most journal publications on leadership and climate change deal with leadership in the context of mitigation policies (eg, Xxxxx Observatoryand Xxxxx, 2000; Xxxxxxxx and Xxxxxxxxxx, 2007). Second, contributions which refer to leadership in the context of climate change adaptation tend to identify it as only one of the factors needed for successful adaptation (eg, Xxxxx, 2010; Xxxxx et al, 2010) or to manage local-level conflicts between mitigation and adaptation measures (eg, Xxxxxxxxx et al, 2009). Others consider leadership at only a high level of abstraction—like Underdal (2010), who compares the merits of the collective action model (involving centralized leadership) versus adaptive governance in responding to complex governance challenges such as climate change. These examples do not take leadership as their main focus and fail to address it in a theoretically informed and systematic way. With this paper we aim to fill this apparent gap by exploring the relevance of modern leadership concepts for climate change adaptation. As there is an impressive body of current literature on leadership in general [for a good general review see, for example, Xxxxxx et al (2009)], we necessarily had to make a selection of leadership theories that are particularly useful for studying leadership for climate adaptation. We have based our selection on the key characteristics and related leadership challenges of climate change adaptation. First, when considering climate adaptation, we observe an important role for government actors and public policy (Xxxxxxxxx et al, 2010). Both private and public parties may play a crucial role in realizing climate adaptation. Citizens, industries, or farmers may adapt autonomously, for example by moving out of flood-prone areas or by growing new crops. However, in modern societies public policy is crucial to climate adaptation. In a way this is unsurprising, since many of the proposed policy options for adaptation—for instance, the strengthening of xxxxx or the creation of space for rivers— are collective action problems that need to be addressed by public policy (Osberghaus et al, 2010). Therefore, we first turn to the role of leadership in the policy process. Second, climate adaptation creates a need for coordinating different levels, actors, and sectors (Xxxxxxxx et al, 2010; Xxxx-Xxxxx, 2009). As is the case in many other policy areas, knowledge and other resources are disseminated amongst a network of actors. In a ‘shared power’ world there is a need for coordination between various levels of government (Xxxxxxx and Xxxxxxxxx Xxxxxxx, 2007), policy sectors, and public and private actors. Third, policies of climate change adaptation need to take into account the relevance of the interactions between social and ecological systems (Xxxxx et al, 2005). Most adaptation options have an impact on natural or ecological systems, such as water systems, agricultural land, or nature; and feedback from the natural system—such as flood events, periods of drought, or heat waves—plays an important role in the adaptation process. Because of these interactions between social and ecological systems there is a need to be sensitive to feedback mechanisms and to anticipate long-term consequences of climate change. The identification need for using a long-term perspective in developing and implementing adaption options is efficiently performed pressing: new xxxxx are being designed to guarantee safety for neutrinos of all flavors interacting at least a few decades; and to be able to
(1) Our searches concentrated on scientific journals in the atmosphere at large zenith anglesISI Web of Knowledge and Scopus databases. In a first round of searches we used the keywords ‘climate change’ AND ‘leadership’ (OR entrepreneurship OR policy entrepreneur OR leader OR change agents). Subsequently, in a second round, we added to these a third keyword, ‘adaptation’ (OR ‘adaptive capacity’ OR ‘adaptability’ OR ‘resilience’). accommodate a future increase in peak river discharges, we need to make spatial reservations for future water retention areas now. Finally, uncertainty and unpredictability are key characteristics of the issue of climate change adaptation. Xxxxxxxxxx et al (2010) distinguish three types of uncertainty: macro- uncertainty is uncertainty about the phenomenon of climate change—that is, about the speed and degree of climate change; microuncertainty is uncertainty about the impact that climate change will have on a specific region; and technological uncertainty is uncertainty about future options in mitigation and adaptation. Next to these uncertainties in the behaviour of natural systems and technology development, there is also uncertainty about the way in which society responds to climate change and about the interactions between social and natural (ecological) systems. Social–ecological systems are nondecomposable systems which are characterized by complexity, variety, spontaneity, and nonlinearity (Xxxxxxxx, 2006; Xxxxxxx et al, 2009). It is exactly because of this uncertainty and fundamental unpredictability that the adaptive capacity or adaptability of socioecological systems needs to be improved and that leadership should create room for or stimulate variety and experimentation (Xxxxxx et al, 2006). Similarly, the literature on adaptive governance or adaptive (co)management suggests that learning and experimentation enhance the adaptive capacity of a governance system (Xxxxxxx et al, 2009). These four characteristics of climate change adaptation lead to four main challenges which leadership needs to address. Leadership in climate adaptation needs to:
(1) influence the policy process so as well to get adaptation policies accepted and implemented;
(2) enhance connectivity across different policy-making levels, sectors, and actors;
(3) enhance the capacity of society to learn in response to feedback from the natural system and to anticipate long-term impacts of climate change;
(4) increase the adaptive capacity (adaptability) of governance networks concerned with climate adaptation. By defining these leadership challenges, we do not contend that leadership is the only relevant factor in climate adaptation. Xxxxx et al (2005) mention the existence of bridging organizations, enabling legislation and governmental policies, and crises (as opportunities) as factors which, along with leadership, are relevant to realizing adaptive governance of social– ecological systems. Xxxxx et al (2010) distinguish six dimensions of the adaptive capacity of institutions for Earthclimate change: resources, variety, fair governance, learning capacity, room for autonomous change, and leadership. Drawing on an extensive literature review, Armitage (2005) distinguishes ten factors influencing the adaptive capacity for community-skimming τ neutrinos based natural resources management. The political factor includes different forms of leadership. Neither of these theories indicates the relative importance of leadership as compared with nearly tangential trajectories relative the other factors; what they have in common is that they recognize leadership as one important factor next to more structural ones. That is why we believe the Earthleadership factor warrants special attention. No neutrino candidates were found By taking an agency perspective, however, we do not preclude that some policy contexts may be more enabling for particular types of leadership than others. Since the four leadership challenges relate to multiple disciplines within the social sciences—including policy science and public administration, organizational and manage- ment science, business ethics, and beyond (ie, the life sciences, regarding the third challenge)—the following sections will introduce leadership concepts from four different bodies of literature:
(1) Theories on leadership in ∼ 14.7 years of data taken up to 31 August 2018the policy process [eg, policy entrepreneurship and ideational leadership (IL)]. This leads literature addresses explicitly the role of leadership in changing and implementing public policy.
(2) Leadership for connectivity (collaborative, catalytic, or integrative leadership). This literature discusses the role of leadership in establishing connectivity across different levels, sectors, and actors.
(3) Sustainability leadership theory (theories on ecoleadership and social–ecological systems). This literature focuses on the role of leadership in managing social–ecological systems and in realizing sustainability.
(4) Complexity leadership theory (CLT). This leadership theory discusses how leadership may enhance the adaptive capacity of organizations. After describing the essence of each leadership concept, we will present a systematic comparison looking for overlapping and complementary insights. Finally, drawing on the different leadership concepts and the comparative analysis, we present an integrative framework for analyzing leadership for climate change adaptation.
(1) display high levels of social acuity (or perceptiveness), (2) pay close attention to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–problem definition,
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal PCCP PAPER Cite this: Phys. Chem. Chem. Phys., 2018, 20, 28319 Received 24th May 2018, Accepted 24th October 2018 DOI: 10.1039/c8cp03314e xxx.xx/xxxx Structural characterization of Cosmology nucleotide 50-triphosphates by infrared ion spectroscopy and Astroparticle Physics JCAP10(2019)022 Etheoretical studies† Xxxxxx X. xxx Xxxxxxxxxx, a Xxxxxxxx Xxxxxxx, a Xxxx Xxxxxx, a Xxxxxxx X. Xxxxxx,a Xxx Xxxxxx ab and Xxxxx X. Xxxx *a The molecular family of nucleotide triphosphates (NTPs), with adenosine 50-mailtriphosphate (ATP) as its best-known member, is of high biochemical importance as their phosphodiester bonds form Nature’s main means to store and transport energy. Here, gas-phase IR spectroscopic studies and supporting theoretical studies have been performed on adenosine 50-triphosphate, cytosine 50-triphosphate and guanosine 50-triphosphate to elucidate the intrinsic structural properties of NTPs, focusing on the influence of the nucleobase and the extent of deprotonation. Mass spectrometric studies involving collision induced dissociation showed similar fragmentation channels for the three studied NTPs within a selected charge state. The doubly charged anions exhibit fragmentation similar to the energy-releasing hydrolysis reaction in nature, while the singly charged anions show different dominant fragmentation channels, suggesting that the charge state plays a significant role in the favorability of the hydrolysis reaction. A combination of infrared ion spectroscopy and quantum-chemical computations indicates that the singly charged anions of all NTPs are preferentially deprotonated at their b-phosphates, while the doubly-charged anions are dominantly ab-deprotonated. The assigned three-dimensional structure differs for ATP and CTP on the one hand and GTP on the other, in the sense that ATP and CTP show no interaction between nucleobase and phosphate tail, while in GTP they are hydrogen bonded. This can be rationalized by considering the structure and geometry of the NTPs where the final three dimensional structure depends on a subtle balance between hydrogen bond strength, flexibility and steric hindrance. Introduction Nucleotide triphosphates (NTPs) drive many central cellular processes including nucleic acid synthesis,1 energy transfer2 and signalling processes.3 NTPs share a common structure com- prising a nitrogen-containing base, a ribose and three phosphate groups (labelled a, b and g, see Fig. 1) and vary in the identity of the nucleobase.4 Among the family of NTPs, adenosine 50-triphosphate (ATP) has received particularly much attention as it is Nature’s main means to capture, transiently store and transfer the energy needed to drive biochemical conversions.5,6 The chemical energy in ATP, and more generally in all NTPs, is stored in the covalent phosphodiester bonds linking the a–b and b–g
Fig. 1 Chemical structures of fully protonated ATP, CTP and GTP. The colours indicate the base (blue), ribose (green) and triphosphate (red) groups. The standard labelling for triphosphate groups and nucleotide † Electronic supplementary information (ESI) available. See DOI: auger xxxxxxxxxxxxx@xxxx.xxx Received June 1910.1039/ c8cp03314e
1. The most commonly occurring energy-releasing reaction in nature is the hydrolysis reaction in which the bg-bond breaks, 2019 Accepted September 5yielding a phosphate (Pi) and adenosine 5'-diphosphate (ADP). Cells use the energy released during this reaction to drive their activities by the protein- mediated coupling of this reaction to reactions that require energy.7 Since the function and recognition of a biomolecule are tightly related to its three-dimensional structure, 2019 Published October 8detailed insight into the structure of the family of NTPs expedites a full biological understanding. NTPs can be deprotonated at their a-, 2019 Abstractb- and g-phosphates and several are indeed deprotonated at physio- logical pH. The resulting negative charge is stabilized by hydrogen bonds, which largely cement the molecule’s three- dimensional structure.8 In addition, under biological conditions, NTPs are complexed to water molecules, amino acid residues, and metal cations, which stabilize the negative charges on the phosphate groups in solution and catalyse reactions involving NTPs.9–12 In the solid phase, X-ray diffraction data is available for some ATP salts,13–18 which show a characteristic folding of the phosphate chain towards the nucleobase. Neutrinos with energies above 1017 eV are detectable The phosphate chain chelates the metal cations and interactions of the nucleobase nitrogen atoms with the Surface Detec- tor Array cation are rare. The ribose ring commonly adopts a C(2')- or C(3')-endo conformation and the adenine group is in the anti-conformation. The crystals have a doubly charged phosphate chain and a protonated nucleobase, which differs from biological situations. Moreover, it was not possible to crystallize complexes involving divalent cations because of the Xxxxxx Xxxxx Observatoryinstability towards hydrolysis. The identification However, it was possible to determine the structure of proteins that bind NTPs as ligands.19 Surveys of either ATP/GTP binding sites20 or protein structures containing Mg:nucleotide complexes21 from the Protein Data Bank22 show that the nucleotide has an extended conformation in most cases, so that there is efficiently performed for neutrinos of little interaction between the nucleotide and b- and g-phosphate. Additionally, almost all flavors interacting proteins bind the NTPs in the atmosphere at large zenith anglesanti- conformation.19 In solution, nuclear magnetic resonance (NMR) studies have shown that NTPs, just as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eVsolid phase, occur predomi- nantly with their base in the anti-conformation.12,23,24 More- over, several studies addressed the acid–base properties of NTP’s in aqueous solutions, evidencing that the phosphate-tail is predominantly in its fully deprotonated form. Decreasing the pH of the solution results firstly in protonation of the g-phosphate, secondly in protonation of the nucleobase and finally in proto- nation of the rest of the phosphate tail.8,25–27 Protonation of the nucleobase occurs at N1 of ATP, N7 of GTP and N3 of CTP (see Fig. 1). Structural studies of biomolecules in the gas-phase add valuable information to condensed-phase studies, since they offer the opportunity to reveal the intrinsic properties of a molecule isolated from the influence of interactions with other molecules or water. Especially the combination of gas-phase infrared spectroscopy and quantum-chemical calculations has been very successful in determining the structure of many bio- molecular systems.28 Several experimental and theoretical studies have focussed on ATP in the gas phase.29–34 Akola and Xxxxx performed a
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal DOI 10.1007/s00253-014-5766-8 MINI-REVIEW PQQ-dependent methanol dehydrogenases: rare-earth elements make a difference Xxx X. Keltjens • Arjan Pol • Xxxxxxx Xxxxxxx • Huub X. X. Op den Camp Received: 11 February 2014 / Revised: 7 April 2014 / Accepted: 8 April 2014 / Published online: 13 May 2014 Ⓒ Springer-Verlag Berlin Heidelberg 2014 Abstract Methanol dehydrogenase (MDH) catalyzes the first step in methanol use by methylotrophic bacteria and the second step in methane conversion by methanotrophs. Gram-negative bacteria possess an MDH with pyrroloquinoline quinone (PQQ) as its catalytic center. This MDH belongs to the broad class of Cosmology eight-bladed β propeller quinoproteins, which comprise a range of other alcohol and Astroparticle Physics JCAP10(2019)022 Ealdehyde dehydrogenases. A well-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19investigated MDH is the heterotetrameric MxaFI-MDH, 2019 Accepted September 5which is composed of two large catalytic subunits (MxaF) and two small subunits (MxaI). MxaFI-MDHs bind calcium as a cofactor that assists PQQ in catalysis. Genomic analyses indicated the existence of another MDH distantly related to the MxaFI-MDHs. Recently, 2019 Published October 8, 2019 Abstractseveral of these so-called XoxF-MDHs have been isolated. Neutrinos with energies above 1017 eV XoxF-MDHs described thus far are detectable with homodimeric proteins lacking the Surface Detec- tor Array small subunit and possess a rare-earth element (REE) instead of the Xxxxxx Xxxxx Observatorycalcium. The identification is efficiently performed presence of such REE may confer XoxF-MDHs a superior catalytic efficiency. Moreover, XoxF-MDHs are able to oxidize methanol to for- mate, rather than to formaldehyde as MxaFI-MDHs do. While structures of MxaFI- and XoxF-MDH are conserved, also regarding the binding of PQQ, the accommodation of a REE requires the presence of a specific aspartate residue near the catalytic site. XoxF-MDHs containing such REE-binding mo- tif are abundantly present in genomes of methylotrophic and methanotrophic microorganisms and also in organisms that hitherto are not known for neutrinos such lifestyle. Moreover, sequence analyses suggest that XoxF-MDHs represent only a small part of all flavors interacting putative REE-containing quinoproteins, together covering an unexploited potential of metabolic functions. Keywords Methanol dehydrogenase . Alcohol dehydrogenase . Pyrroloquinoline quinone . Rare-earth elements . Methylotrophy . Methanotrophy Introduction Methanol serves as the carbon and energy source for a large variety of obligate and facultative methylotrophic microorgan- isms. Phototrophic prokaryotes may use methanol as the electron donor for anoxygenic photosynthesis and respiration (Xxxxxx and Xxxxxxx 1975; Xxxx et al. 1976). Plants excrete methanol from their root systems and leaves (Xxxx and Xxxxxx 1996; Xx et al. 2005; Abanda-Nkpwatt et al. 2006). Here, methylotrophs are particularly abundant as plant pathogens and nitrogen-fixing symbionts (Xxxxxxx 2012). They even assist in plant development by providing plants with pyrroloquinoline quinone (PQQ) (Xxxx et al. 2008). Next, methanol is, after methane, the second most abundant organic compound in the atmosphere at large zenith anglesatmosphere, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to and methanol deposited in the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos ocean surface provides marine microbes with an Eν−2 spectrum important carbon and energy source (Yang et al. 2013). In addition to being a primary substrate, methanol is the first intermediate in methane oxidation in methanotrophs that thrive on the energy range 1.0 × 1017 eV–Electronic supplementary material The online version of this article (doi:10.1007/s00253-014-5766-8) contains supplementary material, which is available to authorized users.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Eur J Crim Policy Res (2015) 21:83–97 DOI 10.1007/s10610-014-9237-7 Combating Hooliganism in the Netherlands: An Evaluation of Cosmology Measures to Combat Hooliganism with Longitudinal Registration Data Xxxxxx Xxxxxx • Maarten Xxxxxx • Xxxxxxx Xxxxxx • Xxxxxx Xxxxxx Published online: 9 April 2014 Ⓒ Springer Science+Business Media Dordrecht 2014 Abstract Football hooliganism is an undesirable but widespread phenomenon. In this contribution, a range of measures to combat hooliganism in the Netherlands is evaluated. We use (logistic) multi- level models to analyze data on hooliganism from the Dutch Football Vandalism Information Office covering 3431 matches in the period 2006–2011. We controlled rigorously for (un)observed heterogeneity between matches and Astroparticle Physics JCAP10(2019)022 Efor differences in expected risk over time. Football matches played early during the day and in daylight are less likely to witness incidents of hooliganism than matches played at a later time and in darkness. The politically sensitive mandatory transport measure decreases the risk of incidents as well. On the other hand, we could not find any evidence for the effectiveness of the mandatory home-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19match cards or mandatory away-match cards. An alcohol prohibition within the stadium causes a waterbed effect, 2019 Accepted September 5increasing incidents outside the stadium. Keywords Alcohol prohibition . Football . Hooliganism . Logistic multi-level models . Policy evaluation Introduction & Theory Introduction Football has been an extremely popular sport for decades. Its popularity seems to be ever- growing, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of 2010 World Cup Championship final in South Africa attracting a total X. Xxxxxx . X. Xxxxxx Socio and Cultural Science at the Xxxxxx Xxxxx Observatory. Radboud University Nijmegen, Nijmegen, The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Netherlands
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Magnetic Resonance in Medicine 64:777–786 (2010) Superselective Pseudocontinuous Arterial Spin Labeling Xxxxxxx Xxxxx,1* Xxxxx X. Xxxxxx,2 Xxxxxxx Xx¨ fer,1 Xxxxxxx Xxxxx,1 Xxxx Xxxxxx,1 and Xxxxxxxx X. X. van Osch3 A new technique for the imaging of Cosmology flow territories of individ- ual extra- and Astroparticle Physics JCAP10(2019)022 Eintracranial arteries is presented. The method is based on balanced pseudocontinuous arterial spin labeling but employs additional time-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with varying gradients in between the Surface Detec- tor Array radiofrequency pulses of the Xxxxxx Xxxxx Observatorylong labeling train. The identification direction of the additional gradient vector is efficiently performed perpendicular to the selected artery and its azimuthal angle is switched after every radiofrequency pulse. The phases of the radiofrequency pulses are adopted to cancel out the phase accrual of the spins at the center of the target vessel due to the extra applied gradients. This results in efficient inversion at the tar- geted position, whereas elsewhere time-varying phase changes will result in marginal inversion efficiency. By xxxxx- ing the moment of the added gradients, the size of the label- ing focus can be adjusted. Influence of the temporal order of the additional gradients on the labeling efficiency and on the selectivity was investigated by simulations and experimental measurements. In a volunteer study, the acquisition of high signal-to-noise ratio flow territory images of small branches of the anterior cerebral artery distal to the circle of Xxxxxx was demonstrated. This shows the method’s flexibility for neutrinos dealing with complicated arterial geometries and its ability to super- selectively label small intracranial arteries. Magn Reson Med 64:777–786, 2010. VC 2010 Xxxxx-Xxxx, Inc. Key words: magnetic resonance imaging; arterial spin labeling; perfusion territories; cerebrovascular disease; cerebral arteries; cerebral arteries The ability to magnetically label blood can be used to set blood spins in a different magnetic state to that of all flavors interacting static tissue and hence affect the contrast of MR images (1). Today, these techniques, known as arterial spin labeling (ASL), are commonly used to measure cerebral perfusion. Compared to other imaging modalities, ASL has the advantage of achieving perfusion-weighted images in a completely noninvasive way by utilizing magnetically labeled blood as a tracer without exposing patients to ionizing radiation and the atmosphere at large zenith anglesadministration of exogenous contrast agents. Recently, different variants of ASL techniques were introduced that enable the mea- surement of flow territories in a completely noninvasive way (2–15). The ability to visualize perfusion territories of the cerebral arteries may be an important tool for many clinical applications and makes it possible to address several clinical questions. In acute stroke, such regional perfusion imaging (RPI) is beneficial in deter- mining the origin of an embolus (16). In chronic cerebro- vascular disease, it was shown that RPI can investigate the extent of perfusion territories of the contralateral in- ternal carotid artery (ICA) and the basilar artery, as well as the contribution of the ipsilateral external carotid ar- tery to cerebral perfusion in patients with symptomatic ICA occlusion (17–21). In patients with symptomatic ICA stenosis, RPI can track alterations in perfusion xxxxx- tories upon carotid endarterectomy and carotid angio- plasty with stent placement (22). Moreover, RPI was used to image the individual contribution of main brain supplying arteries and depict differences in perfusion territories based on anatomic variations of the circle of Xxxxxx (23). In order to enable RPI in clinical routine, the technique should have the following characteristics: First, it should provide a high signal-to-noise ratio (SNR) to be able to detect the flow territories even when these are hypoper- fused and to ensure a convenient examination time. Sec- ond, the measurement setup and preparation should be simple so that there is no utilization of extra hardware necessary and that even for Earth-skimming τ neutrinos tortuous vessels the planning of the labeling is easily accomplished. Third, the tech- nique should be as selective as possible, in particular when the aim is to perform RPI in patients with nearly tangential trajectories relative altered arterial architecture in whom it is advantageous to label a single artery to avoid ambiguity in the interpretation of the results. Fourth, the technique should allow for tuning of the selectivity by adjusting the size of the labeling spot. This is important when adjacent vessels are located close to the Earthtargeted vessel and to enable proper labeling in ves- sels with different diameters. No neutrino candidates were found in ∼ 14.7 years However, none of data taken up the existing RPI techniques fulfill all these criteria. The existing RPI techniques are either based on pulsed ASL or on continuous ASL (CASL). The most promising pulsed ASL RPI technique involves angu- lations and translation of the inversion slab to 31 August 2018selectively label the ICA or the posterior circulation (5–7,15). This leads to restrictive upper bounds on their fluxmethod implies careful planning of the labeling slab 1Institute of Neuroradiology, Xxxxxxxxx-Xxxxxxxxx-Universita¨ t, Kiel, Germany. 2Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Netherlands.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Psychophysiology, 40 (2003), 60–68. Xxxxxxxxx Publishing Inc. Printed in the USA. Copyright Ⓒ 2003 Society for Psychophysiological Research Auditory event-related potentials in humans and rats: Effects of Cosmology task manipulation XXXX XXXXXXX, J. H. R. XXXX, XXXXXX XXX LUIJTELAAR, XXXXXXXX X. X. XXXXXXXXX, MARIJTJE X. X. XXXXXXX, AND XXXXXXXXXX X. XXX XXXX Nijmegen Institute of Cognition and Astroparticle Physics JCAP10(2019)022 Information/Department of Biological Psychology, University of Nijmegen, Nijmegen, The Netherlands Abstract The purpose of this study was to compare components of the rat and human auditory event-related potential (ERP) as generated in active oddball and passive single-stimulus tasks. The rats were trained to discriminate between target and standard stimuli in an oddball task, whereas the human subjects received instructions. Task effects on various ERP components were found in both species. Interestingly, effects on the P3 component were similar in the species with regard to amplitude: Target stimuli elicited a higher amplitude in the oddball task than did standard stimuli. This might indicate that the P3 shares the same characteristics between species. However, the first four components occurred 1.82 times earlier in rats than in humans, expecting a P3 of about 200 ms in rats. The P3 in rats appeared at 380 ms. We conclude that either the relation between human and rat peak latencies is not linear, or the P3 in rats is not the equivalent of the human P3. Descriptors: Auditory event-related potential, P3, Oddball task, Human, Rat Event-related potentials (ERPs) are averaged electroencephalo- graphical potentials triggered by, and time-locked to, sensory stimuli (Na¨ a¨ ta¨ nen, 1990). These potentials consist of various components that are either defined by polarity and order of occurrence (e.g., N2 is the second negative component), or by polarity and latency (e.g., P300 is a positive component approximately 300 ms after stimulus onset). ERPs can be used to study information processes. Numerous ERP studies have been performed in humans, often in a so-called oddball paradigm. Frequently occurring standard stimuli are interspersed with infrequently occurring target stimuli, and subjects are instructed to count targets or to press a button after the presentation of the target stimulus. Both the N1, which is suggested to be involved in attention processes (Garcı´a-Larrea, Xxxxxxxxxxx, & Xxxxxxx` re, 1992; Na¨ a¨ ta¨ nen, 1990), and the P3, which is involved in stimulus evaluation (Xxxxxxx, 1981), usually have a larger amplitude for target than for standard stimuli (Xxxxxxx, Xxxxxxx, & Xxxxxxxxx, 1987; Xxxxx & Xxxxxx, 2000; Xxxxxxxxx et al., 1996). The latencies of the N1 and P3 are generally longer at target in comparison to standard stimuli or to stimuli in a passive paradigm requiring no response (Xxxxxx & Xxxxxxx, 1990; Xxxxxxx & Xxxxxx, 1997). In addition, ERP studies have been performed in nonhuman species (Molna´ r, 1994). Monkeys (Xxxxxx, Xxxxxx, Xxxxxxxx, & Xxxxx-Xxxxxxx, 1986; Xxxxxx, XxXxxxxx, Xxxxxxxx, Xxxxxxx, & Xxxx, 1992), cats (Bas,xx-Xxxxxx, Xxx,ar, & Xxxxxxxxx, 1991; Xxxxxxxx, Xxxxxxxx, Xxxx, Xxxxx, & Xxxxxxx, 1988), and xxxxxxx (Xxxx, Xxxxxxxxx, Xxxxx, & Xxxxxxxxx, 1998) all show a component in the cortical EEG that resembles the human P3 with respect to latency. Although a component (250–500 ms) that is somewhat similar to the human P3 with respect to latency has also been found in rats (Brankacˇ k, Xxxxxxxxxxxx, & Mu¨ ller- Ga¨ rtner, 1996; Xxxxxx, Xxxxxx, Xxxxxxx, & Xxxxx, 1994; Xxxxxxx, Xxxxx, & Xxxxxxxxxxx, 1987; Jodo, Xxxxxxxx, & Xxxxxx, 1995; Xxxxxx, 1999), others proposed that an earlier component (220–240 ms) might be considered as the equivalent of the P3 in the rat (Galicia et al., 2000; Xxxxxxxxx, Globus, & Xxxxxx, 1993). Latency alone however is not sufficient for suggesting equivalence of the P3 between rats and humans. Besides latencies, there are other uncertainties with respect to the P3 in rats. Much less work has been performed in rats than in humans. Its sensitivity to task manipulations is hardly described, and the Xxxxxx xxx Xxxxxxx, Xxxxxx Xxxxx, Xxxx Xxxxxxx, Xxxx-Xxxx Xxxxxxx, Xxxx Xxxxxxx-xxx Xxxx, Francien van de Pol, and Xxxxx Xxxxx are thanked for their (bio)technical support. Prof. dr. A. M. L. Xxxxxx is greatly acknowledged for making this study possible. Address reprint requests to: X. X. xxx Xxxx, MD, PhD, NICI/ University of Nijmegen, Xxxxxxxxxxxxxx 0, Xxxxxxx 0000, 0000 XX Xxxxxxxx, Xxx Xxxxxxxxxxx. E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19xxxx@xxxx.xxx.xx. (Xxxxxxxˇ k et al., 2019 Accepted September 51996; Xxxxxxx et al., 2019 Published October 81987; Jodo et al., 2019 Abstract1995). Neutrinos with energies above 1017 eV are detectable with This is important because amplitudes of earlier components might influence the Surface Detec- tor Array amplitude of the P3. A final point to bear in mind is the expected latency of components. As noted, some authors suggest that the latency of the P3 is the same in rats and humans (Brankacˇ k et al., 60 1996; Xxxxxx Xxxxx Observatoryet al., 1994; Xxxxxx, 1999). However, the brain of rats is much smaller than that of humans. Therefore the conduction of a signal is faster, which should result in shorter latencies of components in rats compared to humans. This might imply that the P3 in rats, as found in some earlier studies, might not be the equivalent of the human P3 (Jodo et al., 1995; Xxxxxx, 1997; Xxxxxxxxx et al., 1993), but merely a reflection of some other late cognitive process. Direct comparisons between the human and rat ERP were not made until now, although comparative studies form the basis for the search for the nonhuman equivalent of the human ERP, particularly the P3. These studies are important, as such research may constitute a necessary basis for the establishment of neurophysiological substrata of cognitive processes. ERPs, as obtained in different species with an oddball paradigm, can be compared on similarities and differences in, for example, topographical localization, influence of task manipulation, and effects of drugs. One may have an argument for their equivalence if the components of the ERP in different species react in the same way in those species. The identification is efficiently performed for neutrinos present experiments assess the effects of all flavors interacting in task manipula- tion on the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years ERP of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxhumans and rats. The 90% C.L. singlesubjects first received auditory target and standard stimuli in an active oddball task, and, subsequently, auditory stimuli in a passive single stimulus paradigm. Methods The present experiment was part of a larger study performed at the University of Nijmegen. The effects of a drug on the ERP were investigated in a double-flavor limit to blind, placebo-controlled study in humans. In rats, silastic implants were used. Only the diffuse flux data of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–placebo groups will be reported here.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal the concept of Cosmology the state in political philosophy Department of Public Administration and Astroparticle Physics JCAP10(2019)022 Political Science, Institute for Management Research, Radboud University Nijmegen, PO Box 9108, 6500 HK Nijmegen, the Netherlands E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19x.xxxxxxxxxx@xx.xx.xx *Corresponding editor. doi:10.1057/eps.2010.56 Abstract In a lecture given in 1991, 2019 Accepted September 5while working on the never finished third volume of his series on theories of justice, 2019 Published October 8Xxxxx Xxxxx gave a rare glimpse into the ideas with which he was wrestling – twenty years ahead of present-day political theorists. What is the role of the state, 2019 Abstracthow are we to conceptualize it, in a world if globalization, and against the background of a legitimate appeal for international distributive justice? Keywords international justice; social justice; sovereignty; state T EDITOR’S NOTE 92 european political science: 10 2011 at his talk into an article. Neutrinos Moreover, the notes he used were already part of the book manuscript he was working on at the time – the never completed third volume of his treatise on social justice. Xxxxx felt that turning the lecture into an article would add little to, and only distract from his work on, the book – but he did not mind publication in the form I proposed: authorized lecture notes dis- playing one of the best political philoso- phers of our days struggling to perfect and further develop his ideas though debate with energies above 1017 eV are detectable his critics. The text was offered for publication in the journal of the Dutch Political Science Association in the autumn of 1991, but its editors neither appreciated the format, nor were they (92 – 102) & 2011 European Consortium for Political Research. 1680-4333/11 xxx.xxxxxxxx-xxxxxxxx.xxx/xxx/ impressed by the novelty of what Xxxxx had to offer. It was rediscovered in 2009 in the process of converting files, created with now defunct word processing software, to a more current format. I have added nothing to the original text, except a couple of references to Xxxxx Xxxxx’x own (later) work. Although little of what Xxxxx had to say is really surprising, from the point of view of 2009, the text does offer a rare glimpse into the ideas with which Theories of Justice: Volume III might have begun, and for the biographer it shows the very first signs of his growing impatience with academic political philosophy. The 1991 lecture was prepared while he was working on the final draft of his second volume in the Theories of Justice series – or so he thought at the time. However, Xxxxx Xxxxx always refused to publish any text he was not deeply satisfied with; hence, Justice as Impar- tiality did not appear until 1995. Volume III – which, as Xxxxx announced in 1991, would discuss international justice – was never finished. Moreover, he soon changed his plans and intended to devote Volume III to the institutions of justice (cf. Xxxxxxx, 2009). Instead, after a period during which Xxxxx wrote about environmental and intergenerational justice, he aban- doned purely ‘academic’ political theory completely in favour of more involved writing like Culture and Equality (2002) and Why Social Justice Matters (2005). As Xxxxx Xxxxxxx (2009) noted, Xxxxx left behind the manuscript of a book on international social justice, all but finished in 1980: Rich Countries and Poor Coun- tries. Had it been published then, the book would have set him on a collision course with Xxxxxxx Xxxxx (1979) and Xxxxxx Xxxxx (1989), the first major thinkers to apply Xxxx Xxxxx’ theory of social justice on a global scale (the oracle himself remained silent on global justice until 1997; cf. Xxxxx, 1999). While Xxxxx certainly agreed with the Surface Detec- tor Array cosmopolitans on the existence of global distributive ‘y American academics in general attach far too much importance to the state and far too easily assume that only a world injustice and of moral obligations towards the world’s poor, the 1991 lecture illustrates that, and why he had little faith in global redistributive institutions or powers. Justice requires a commitment, a sense of belonging, to a cooperative venture, and it requires strong institutions to effectively implement redistribution, neither of which a global society or world state can offer in any foreseeable future. A position like this might be taken as support for Xxxxx’ later rejection of global justice; for Xxxxx (1999), the reciprocity, broadness, intensity and duration of the Xxxxxx ties that make a people a people justify limiting social justice to within the bor- ders of its state, and justify the rejection of global redistribution. Yet the most important message in Xxxxx’x 1991 lec- ture is that Xxxxx Observatoryand – as we can sense in Xxxxx’x reply to a comment by Xxxxxxx Xxxxxxxx – American academics in gen- eral attaches far too much importance to the state and far too easily assumes that only a world state can be an alternative for the classical nation-state. Xxxxx calls for a far more flexible understanding of structures of social cooperation, reflecting a political reality in which state authority ‘leaks away’ to sub- and supranational institutions, and in which peoples, socie- ties and cooperative ventures are not necessarily identical (cf. also Wissenburg, 2007). In this respect, Xxxxx was at least a decade ahead of, and may still inspire, current academic debates on the right to partial or total secession, on the justification of borders per se, and about the (at least contractual) justification of governance and institutions of governance. XXXXX XXXXX’X LECTURE Undoubtedly, Xxxx Xxxxx’ A Theory of Justice (1971) has been responsible for an upsurge in the production of political philosophical literature. Yet little of what has been written since – including my own work – concerns the concept of the state. Modern political philosophy takes the state and its boundaries as a given, in sharp contrast to classic contract theor- ists like Xxxxxx, Xxxxx, and Xxxxxxxx. Xxxxx himself is a good example: his theory is built on the assumption of a certain kind of society, characterized as a group of people living in a state, with a common sense of justice, and rules to which they agree and generally adhere. A society is, furthermore, supposed to know no immigration or emigration, to be economically self-sufficient, and to have no external obligations of any kind. In short, Xxxxx’ view of society is not xxx- xxxxx for this century; an organization like the UN does not fit into his theory. Within this framework, Xxxxx develops a social-democratic theory of the rights of citizens. His explicit aim is the reconcilia- tion of liberty and equality by means of his two principles. Liberty in these principles is represented by civil liberties and the free- dom to follow one’s preferences; equality is the basic principle of distribution. How- ever, the theory has a hidden third leg – efficiency. Xxxxx turns the Pareto-principle of rationality or efficiency into a principle of justice. He allows deviations from equality in those cases where an unequal distribution would make someone better off than she was before, without making anyone else worse off. From these possi- ble Pareto-optimal distributions, Xxxxx then selects the most equal distribution, the one that makes the worst-off in society best off – the so-called maximin-rule. Now Xxxxx is important for two reasons. Firstly, he is politically important. Ever since the publication of his book, it seems clear to us that if a moderately redistribu- tive welfare state – like ours – can be defended, then Xxxxx’ theory would be best suited. Secondly, he is intellectually important as he has set the agenda for political philosophy, leaving open numer- ous lines for criticism and revision. Let me illustrate four possible types of move towards Xxxxx. Firstly, Xxxxx’ argu- ments can be criticized, especially his Original Position and the derivation of his principles from this version of the state of nature. There are other conceivable ori- ginal positions, and I think mine is one of the more interesting (cf. Xxxxx, 1989). Secondly, there are internal problems of consistency in his theory. His principle of distributive justice – the ‘difference principle’ – for instance combines two political theories in one: Xxxxxx’s, which is welfare-based, and his own, which is resource-based. The identification is efficiently performed for neutrinos effect of all flavors interacting applying this principle might be that someone gets paid more (resources) as an incentive to work harder in the atmosphere at large zenith anglesinterest of society, but in fact works less hard, and therefore has more welfare. The difference principle is intuitively appealing, but cannot be taken seriously as it stands now. the social security of a welfare state. I now switch to autobiography for a short personal statement. I feel com- mitted to both the political and the intellectual programme of Xxxxx: I think the Western European arrangements of societies are better than any existing alternative, and I think that changes in these arrangements must be defended from within the existing framework. The most fruitful approach to political theory is contractual, that is, justification of theories by agreement under ideal con- ditions. Xxxxxxx Xxxxx’ Political Equality (1990) is an excellent example of this approach, as well is my own three-volume treatise on social justice1 – though I fear it will turn out in the same way as for Earth-skimming τ neutrinos with nearly tangential trajectories relative my Political Argument (Xxxxx, 1968), which seems to have been the Earthlast contribution to linguistic philosophy. No neutrino candidates were found My book on social justice may be seen as the end of the line, while the philosophical debate is moving into new territory. I do not think that I am saying the last word on the subject, but perhaps our energy can be spent in ∼ 14.7 years better ways. Now why do I say this? Because build- ing theories of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxthis kind is more costly than beneficial. The 90% C.L. singleadvantages are real; there is now a well-flavor limit to worked out tradition for analysing states – but the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum problem is that the conceptual net catches too little reality. Compare Xxxxx’ assumptions about the state: the facts are that there are many political decisions taken outside the state’s borders – for example in the energy range 1.0 × 1017 eV–the
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal For additional information about this publication click this link. xxxx://xxx.xxxxxx.xxx/2066/46046 Please be advised that this information was generated on 2019-02-17 and may be subject to change. Taking Economics to Bed: An Essay about the Pitfalls and Possibilities for Cultural Economics Xxxxxxx Xxxxxxxx, University of Cosmology and Astroparticle Physics JCAP10(2019)022 ENijmegen October 2005 Culture as a topic in economics is currently experiencing a come-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstractback. Neutrinos with energies above 1017 eV are detectable with On the Surface Detec- tor Array wings of the Xxxxxx Xxxxx Observatorynew institutionalism, there has been increasing attention to the role of culture in explaining economic phenomena. However, it is argued that culture lacks a clear definition, and that the theoretical underpinnings of the current attempts to re-introduce culture into economics are weak. This paper will discuss the problems and possibilities of such integration. Starting point is a historical discussion of the reasons why culture does not already play a role in economics. Once we have thus grasped the problem to its fullest, it is argued that there are three main routes for bringing culture into economics. The identification first route is efficiently performed for neutrinos through preferences, which the paper holds to be possible but not very illuminating theoretically; the second is through constraints, which seems more promising but suffers from several theoretical failings; and the third is as complementary deviation from the economic model. On basis of all flavors interacting a conceptual discussion of what culture means in economics, it is argued that the atmosphere at large zenith anglesthird route, in spite of possible appearances, actually has the most potential. However, this project does require a move towards a more reflexive methodology. This implies a questioning of definitions of economy and culture, instead of deductive reasoning on basis of pre-given definitions, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative neoclassical theory is wont to do. A ‘new cultural economics’, in order to be successful, would end up discussing the Earth. No neutrino candidates were found in ∼ 14.7 years field of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to economics itself, questioning divisions that have set it apart from the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–other social sciences.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University Journal of Cosmology and Astroparticle Physics Measurement of the average shape of longitudinal profiles of cosmic-ray air showers at the Xxxxxx Xxxxx Observatory To cite this article: X. Xxx et al JCAP03(2019)018 View the article online for updates and enhancements. You may also like - Limits on point-like sources of ultra-high- energy neutrinos with the Xxxxxx Xxxxx Observatory
X. Xxx, X. Xxxxx, X. Xxxxxxxx et al. - Probing the origin of ultra-high-energy cosmic rays with neutrinos in the EeV energy range using the Xxxxxx Xxxxx Observatory
X. Xxx, X. Xxxxx, X. Xxxxxxxx et al. - Search for magnetically-induced signatures in the arrival directions of ultra- high-energy cosmic rays measured at the Xxxxxx Xxxxx Observatory
X. Xxx, X. Xxxxx, X. Xxxxxxxx et al. ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 JCAP03(2019)018 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19November 13, 2019 2018 Accepted September 5February 25, 2019 Published October 8March 7, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–2019
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with JCAP04(2012)040 A search for anisotropy in the Surface Detec- tor Array arrival directions of ultra high energy cosmic rays recorded at the Xxxxxx Xxxxx Observatory. Observatory The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for EarthXxxxxx Xxxxx collaboration X. Xxxxx,75 X. Xxxxxxxx,58 X. Xxxxxx,110 X.X. Xxx,94 I.F.M. Albuquerque,20 X. Xxxxxx,34 X. Xxxxxxxxx,1 X. Xxxxx,98 X. Xxxxxxx,100 X. Xxxxxx,13,9 X. Xxxxxxx Xxxxxxxx,68 X. Xxxxxxx-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Xxx˜iz,85 X. Xxxxxxxx,51 X. Xxxxxxx,69 X. Xxxxxxxxxxx,111 X. Xxxxxxxx,75 X. Xxxxˇxx’c,28 X. Xxxxx,51
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Neuroethics (2015) 8:327–334 DOI 10.1007/s12152-015-9241-8 ORIGINAL PAPER A Reason To Be Free Operationalizing ‘Free Action’ Xxxxxx Xxxxxxx • Xxx Xxxxxxxxx Received: 20 July 2015 / Accepted: 12 October 2015 / Published online: 31 October 2015 Ⓒ Springer Science+Business Media Dordrecht 2015 Abstract Recent Libet-style experiments are of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative limited relevance to the Earthdebate about free action and free will, and should be understood as investigations of arbitrary actions or guesses. No neutrino candidates were found In Libet-style experiments, the con- cept of 'free action' is commonly taken to refer to a 'self- initiated voluntary act', where the self prompts an action without being prompted. However, this idea is based on the problematic assumption that the conscious self needs to be free from every constraint in ∼ 14.7 years order to be actually free. We maintain that a fundamental condition for free action is the presence of data taken up reasons to 31 August 2018act responsibly. By analyzing a recent neuroscientific experiment, we indi- cate how its results could be interpreted as indicating how free action operationalization is inappropriately focusing on arbitrary actions. Hence, the way free action has been experimentally studied may have had a mis- leading influence on the debate about free will. Keywords Free will . Free action . Voluntary action . Libet . Free selection paradigm . Responsibility. Self generated action . Reasons . Cues . Self Introduction This leads to restrictive upper bounds on their flux. The 90% C.L. singlepaper claims that Libet-flavor limit to style experiments have rela- tively minor implications for the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–debate about freedom of
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Control of Cosmology prehension in hemiparetic cerebral palsy: similarities and Astroparticle Physics JCAP10(2019)022 differences between the ipsi- and contra-lesional sides of the body Xxxx Xxxxxxxxxxx*, Nijmegen Institute for Cognition and Information, Katholieke Universiteit Nijmegen, Nijmegen; Xxxx van der Xxxx, Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands. E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19xxxxxxxxxxx@xxxx.xxx.xx This study aimed at broadening our insight into ipsi- and contra-lesional control of prehension after unilateral brain damage. Six male adults with hemiparetic cerebral palsy (mean age 17 years 3 months, 2019 Accepted September 5SD 15 months) performed unrestricted grasping of discs that differed in size (40, 2019 Published October 860, 2019 Abstractand 80mm in diameter) and which were placed at different distances from the participants (150mm and 30mm). Neutrinos with energies above 1017 eV are detectable A precalibrated Optotrak 3020 system was used for recording motion. Kinematics of the transport and grasp component, and hand orientation at the moment of grasping, were determined. A marker on the wrist was used to calculate the kinematics of the transport component. The distance between the markers on the index finger and thumb was used for the calculation of the grasp component. Kinematic variables of the transport and grasp component were remarkably similar between both sides of the body. However, with the Surface Detec- tor Array contra- lesional side, more time was spent in contact with the object before it was lifted, and movements were performed less fluently compared with the ipsi-lesional side. Maximum grasp aperture was attained very late during reaching. For final hand orientation, results showed a large standard deviation both within and between participants. These findings show that, despite the ostensible awkward prehension movements of the Xxxxxx Xxxxx Observatorycontra-lesional side (slowness and decreased fluency), similarities in the kinematics between both sides of the body are present, which may be indicative of intact central control of the movement. The identification results of variant final hand orientation, combined with the relative late occurrence of peak aperture, suggest that these participants encounter difficulties with forward planning and may use a step-by-step control strategy. In individuals with hemiparetic cerebral palsy (CP), i.e. uni- lateral brain damage acquired before, during, or after birth, the ability to perform a variety of daily activities is efficiently performed reduced. Research on the control of prehension movements in this par- ticipant group is, however, relatively scarce (see Xxxxxxxxxxx and Xxxxxxxx 2001). Generally, CP results in spasticity, a condi- tion that may be characterized as a velocity-dependent increase in tonic reflexes resulting in an excessive and awkward acti- vation of skeletal muscles (Xxxxx 1980, Xxxxxx et al. 1994). Spasticity occurs in a variety of forms and severity levels that reflect the location, size, and timing of the cerebral lesion. Consequently, spasticity is associated with many symptoms, such as excessive coactivation of antagonistic muscles, hyperactive stretch reflexes, associated movements, stereo- typed movement synergies, and hypertonia (Xxxxxxx-Xxxx and Woollacot 1995). Currently, there is a debate as to whether the ostensibly awkward behavioural patterns that one can observe in atypical populations, such as those with hemiparetic CP, should be considered pathological or the result of adaptation process- es (Xxxxxx and Xxxxx 1996, Xxxx-Xxxxx et al. 1997, Xxxx et al. 2000, Xxxxxx and Xxxxxxx 2002, Xxxxx et al. 2002, Xxxxxxxxxxx and Meulenbroek 2003). Importantly, our lack of knowledge about the basic principles of motor control seri- ously complicates a distinction to be made between what may be termed a disorder per se and the short- or long-term adap- tation to this disorder (Gielen 1996, Latash and Xxxxx 1996, Xxxxxxxxxxx and Meulenbroek 2003). Therefore, invari- ances and deviations in movement behaviour of atypical groups need to be meticulously researched in varying exper- imental conditions, so that the principles of (deviant) motor control are better understood and our knowledge of the dis- order-adaptation issue may be advanced. A ubiquitous feature of movement performance in hemi- paretic CP is the presence of large timing differences between the ipsi- and contra-lesional sides (i.e. unimpaired and impaired respectively) of the body (Xxxx and Xxxxxxx 1988; Xxxxx et al. 1989; Xxxxxx and Xxxxx 1995; Xxxxx and Xxxxxx 1998; Xxxxxxxxxxx et al. 1996, 1998, 2000a). A meta-analysis in which unimanual hitting, reaching, and grasping move- ments were compared for neutrinos ipsi- and contra-lesional sides of all flavors interacting the body, showed an increase in manual asymmetries from hitting, to reaching to grasping (Xxx Xxxxx et al. 2000, Xxx Xxxxx and Xxxxxxxxxxx 2001). It was claimed that the larger timing differences could be attributable to the increased involvement of the more distal hand and flnger musculature. Moreover, several studies showed an increased involvement of the proximal trunk and a decreased involvement of the more distal elbow in participants with hemiparesis compared with controls (stroke: Xxxxx 1996, Xxxxxxx and Xxxxx 2000; CP: Xxxxxxxxxxx et al. 2000a; Xxx Xxxx et al. 2003, 2004). Collectively, these flndings suggest that the disorders at the more distal grasp component of the contra-lesional side are augmented, causing the large performance differences between both sides of the body. However, thus far, the char- acteristics of the grasp component of the contra-lesional side have not been studied, nor have the characteristics of the transport and grasp component been examined together in this group of participants (kinematics of the transport com- ponent for both limbs in hemiparetic CP: Xxxxxxxxxxx et al. 2000a; kinematics of the grasp component of the preferred hand in quadriplegic CP: Cope and Xxxxxxx 1998; kinematics of the ipsi-lesional side after stroke: Xxxxxxx 1993, Xxxxx 1996, Xxxxxxxxxxx et al. 1999). In the present study, we examined the kinematics of the transport and grasp component of both sides of the body to search for the invariances in kinematics that have repeatedly been reported in participants without disabilities. Examples of these invariances include influences of object location on the kinematics of the wrist transport (Xxxxxxxxx 1984, Xxxxxxxxxx et al. 1991), and influences of object size on the kinematics of the grasp aperture (Xxxxxxx and Weeks 1988, Xxxxxxxxx et al. 1990, Xxxxx et al. 1997, Xxxxxxxxx et al. 1997). For example, Xxxxxxxxx et al. (1990), using ten discs differing in size, showed distinctive effects of disc size on grasp aperture. When participants without neuroimpairments had to grasp smaller discs, peak aperture was attained earlier and the amplitude of peak aperture was scaled to disc size, such that larger discs induced larger peak apertures. These authors argued that an increase in accuracy constraints of the task, by reducing disc size, is reflected in the atmosphere at large zenith anglestiming of hand opening and closing. Comparison of these previous flndings in controls with par- ticipants of the present study may provide important insights into the principles guiding control of prehension that are unal- tered after unilateral brain damage. In addition, as similarities in the kinematics between both sides of the body in the par- ticipants of the present study may inform us about the cen- tral (re)organization of the underlying control structures after unilateral brain damage. As well as deviations during movement execution, partici- pants with hemiparetic CP also show deviations in the type of grip they use when they grasp an object. In participants with- out disabilities, there is ample evidence to suggest that opti- mization of end posture comfort is used as a constraint on grasp selection (Xxxxxxxxx et al. 1992, 1996; Xxxxxxxxx et al. 1997; Short and Cauraugh 1997, 1999). These flndings may have been altered after unilateral brain damage. Method PARTICIPANTS Six male participants with CP (mean age 17 years 3 months, SD 15 months) and diagnosed with mild spastic hemiparesis participated in the experiment on a voluntary basis. All par- ticipants were students from the Werkenrode Institute, where they followed an adapted education programme. Selection of the participants was based on several criteria. Participants needed to have functional sitting balance without adapted seating aids (on occasions a foot bench was used to enhance the stability of seating). All had normal or corrected-to-nor- mal vision and hearing, no hemi-neglect, and displayed the behavioural and attentional capacities necessary to perform the experiment. We ensured that every participant could reli- ably grasp each of the three discs that were used in the exper- iment, with both the ipsi- and contra-lesional side. Likewise, we ensured that object distance was well within functional reaching distance. Table I presents additional participant infor- xxxxxx. All participants had undergone extensive rehabilita- tion programmes, and their situation was described as stable. Some participants received physical therapy, aimed at pain relief and preventing contractures. Neurophysiological data on the exact location of the lesion were not available because partici- pants were students of the school for Earth-skimming τ neutrinos with nearly tangential trajectories relative to special education, rather than patients in a clinical or medical setting. Participants were naive about the Earthexact purpose of the experiment. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxBefore the experiment, all participants gave written informed consent. The 90% C.L. single-flavor limit to study was approved by the diffuse flux of ultra-high-energy neutrinos local ethics committee and performed in accordance with an Eν−2 spectrum the ethical standards laid down in the energy range 1.0 × 1017 eV–1964 Declaration of Helsinki.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Journal of Cosmology Instrumentation X X Xxxxxxxx Techniques for measuring aerosol attenuation You may also like - Two interacting Ising chains in relative motion - Statistical mechanics of learning using the Central Laser Facility at the Xxxxxx Xxxxx Observatory To cite this article: The Xxxxxx Xxxxx Collaboration 2013 JINST 8 P04009 orthogonal signals for general covariance models Xxxxx X Xxxxx - Random tree growth by vertex splitting X Xxxxx, X X X Xxxxx, X Xxxxxxx et al. View the article online for updates and Astroparticle Physics JCAP10(2019)022 enhancements. Published by IOP Publishing for Sissa Medialab Received: December 18, 2012 Accepted: March 11, 2013 Published: April 12, 2013 2013 JINST E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19P04009 ABSTRACT: The Xxxxxx Xxxxx Observatory in Malargu¨e, 2019 Accepted September 5Argentina, 2019 Published October 8, 2019 Abstract. Neutrinos is designed to study the prop- erties of ultra-high energy cosmic rays with energies above 1017 eV 1018 eV. It is a hybrid facility that employs a Fluorescence Detector to perform nearly calorimetric measurements of Extensive Air Shower energies. To obtain reliable calorimetric information from the FD, the atmospheric condi- tions at the observatory need to be continuously monitored during data acquisition. In particular, light attenuation due to aerosols is an important atmospheric correction. The aerosol concentration is highly variable, so that the aerosol attenuation needs to be evaluated hourly. We use light from the Central Laser Facility, located near the center of the observatory site, having an optical signa- ture comparable to that of the highest energy showers detected by the FD. This paper presents two procedures developed to retrieve the aerosol attenuation of fluorescence light from CLF laser shots. Cross checks between the two methods demonstrate that results from both analyses are detectable with compati- ble, and that the Surface Detec- tor Array uncertainties are well understood. The measurements of the aerosol attenuation provided by the two procedures are currently used at the Xxxxxx Xxxxx ObservatoryObservatory to reconstruct air shower data. The identification is efficiently performed KEYWORDS: Data analysis; Large detector systems for neutrinos of all flavors interacting in the atmosphere at large zenith anglesparticle and astroparticle physics; Detector alignment and calibration methods (lasers, as well as for Earthsources, particle-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. singlebeams) ◯c 2013 IOP Publishing Ltd and Sissa Medialab srl doi:10.1088/1748-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–0221/8/04/P04009 2013
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal DOI 10.1007/s00330-016-4317-3 CHEST Software performance in segmenting ground-glass and solid components of Cosmology subsolid nodules in pulmonary adenocarcinomas Julien G. Cohen1,2 • Jin Mo Goo 1,3 • Roh-Eul Yoo1 • Xxxxx Min Park1,3 • Xxxxx Xxxx Xxx 1 • Xxxx van Ginneken4 • Doo Hyun Chung5 • Young Xxx Xxx 3,6 Received: 8 July 2015 / Revised: 14 February 2016 / Accepted: 2 March 2016 / Published online: 5 April 2016 Ⓒ European Society of Radiology 2016 Abstract Objective To evaluate the performance of software in segmenting ground-glass and Astroparticle Physics JCAP10(2019)022 Esolid components of subsolid nodules in pulmonary adenocarcinomas. glass and solid components with pathology measurements of tumour and invasive components. Results Segmentation of ground-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19glass components at a threshold of -750 HU yielded mean differences of +0.06 mm (p = 0.83, 2019 Accepted September 595 % limits of agreement, 2019 Published October 84.51 to 4.67) and - 2.32 mm (p < 0.001, 2019 Abstract-8.27 to 3.63) when compared with pa- thology and manual measurements, respectively. Neutrinos For solid components, mean differences between the software (at - 350 HU) and pathology measurements and between the man- ual (lung and mediastinal windows) and pathology measure- ments were -0.12 mm (p = 0.74, -5.73 to 5.55]), 0.15 mm (p = 0.73, -6.92 to 7.22), and -1.14 mm (p < 0.001, -7.93 to 5.64), respectively. Jin Mo Goo xxxxx@xxxxx.xxx.xx.xx 1 Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, 000 Xxxxxx-xx, Xxxxxx-xx, Xxxxx 000-000, Xxxxx 2 Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Xxxxxx Xxxxxxx, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France 3 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea 4 Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Center, Xxxxx Xxxxxxxxxxx 00, 0000 XX Xxxxxxxx, Xxx Xxxxxxxxxxx 5 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea ence with energies above 1017 eV pathology. • Software can effectively segment ground-glass and solid components in subsolid nodules. • Software measurements show no significant difference with pathology measurements. • Manual measurements are detectable with more accurate on lung windows than on mediastinal windows. Keywords Solitary pulmonary nodule . Lung cancer . Subsolid nodule . Adenocarcinoma . Segmentation Introduction Persistent pulmonary ground-glass nodules (GGNs) have been a growing concern in the Surface Detec- tor Array last few years because many of them turned out to be pulmonary adenocarcinomas or their precursors [1, 2]. In the 2011 IASLC/ATS/ERS classification [3], it was recommended to report the size of the Xxxxxx Xxxxx Observatorysolid component and entire tumour size separately for part-solid GGNs as the invasive component of pulmonary adenocar- cinoma is closely related to a patient’s prognosis. The identification is efficiently performed for neutrinos A sub- sequent study showed that the diameter of all flavors interacting the solid com- ponent was a better prognostic predictor than the largest diameter of the whole nodule in adenocarcinomas appearing as part-solid GGNs [4]. Therefore, the atmosphere at large zenith angles, diameter of the solid component as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years size of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum whole nodule is a key element in the energy range 1.0 × 1017 eV–recent recommendations for the management of subsolid nodules [2]. However, when the variability of manual measurements was assessed, 95 % limits of interobserver agreement were reported to be 1.72 mm and 1.73 mm for GGNs and solid nodules, respectively [5, 6]. As for a part-solid GGN, the interob- server measurement variability of solid component may be even higher given the fact that solid components are usually very small, with the largest diameters of no more than a few millimetres. Furthermore, given their slow growth rate, it may not be easy to determine interval changes in GGNs with manual measurements, especially when the solid component is small.
Fig. 1 Example of an excellent segmentation for a part-solid GGN in the right upper lobe before (a) and after (b) segmentation with thresholds of - 750 HU and -350 HU for ground-glass and solid components, respectively. Software measurements were 16.8 mm for the ground- glass component and 8.7 mm for the solid component. Pathology obtained with wedge resection revealed a lepidic predominant adenocarcinoma with a maximal tumour size of 17 mm and an invasive component size of 9 mm As computer-aided volumetry was reported to reduce inter- observer variability in solid nodules; a similar approach may be applicable to GGNs [7–9]. While several articles have ex- plored the topic of semi-automated segmentation in GGNs, most of them focused on the feasibility of volumetry and mass measurements as well as their intra/interobserver, and intrascan variability [10–13]. However, these studies did not compare the software measurements with manual measure- ments of maximal diameters of ground-glass and solid com- ponents of nodules, which are still the reference standard for GGNs [2]. More importantly, there have been no studies which compared the software measurements with pathology measurements of invasive components and the entire tumours in pulmonary adenocarcinomas [3].
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Impacts of Cosmology biogenic CO2 emissions on human health and Astroparticle Physics JCAP10(2019)022 E-mailterrestrial ecosystems: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19the case of increased wood extraction for bioenergy production on a global scale ROS A LIE V AN XXXX 1 , 2019 Accepted September 5PATIENCE A . N . M UCHADA 1 , 2019 Published October 8M XXXXX XXX X XX XXXXX 2 , 2019 AbstractXXXXX X XXXXXXXXX 2 , M I CHAEL OBE R ST EI NER 2 and XXXX X. X. XXXXXXXXXX 1 1Department of Environmental Science, Institute for Water and Wetland Research, Radboud University Nijmegen, P.O. Box 9010, Nijmegen, GL 6500, the Netherlands, 2International Institute of Applied Systems Analysis, Ecosystem Services and Management Program, Laxenburg A-2361, Austria Abstract Biofuels are a potentially important source of energy for our society. Neutrinos with energies above 1017 eV are detectable with Common practice in life cycle assessment (LCA) of bioenergy has been to assume that any carbon dioxide (CO2) emission related to biomass combustion equals the Surface Detec- tor Array amount absorbed in biomass, thus assuming no climate change impacts. Recent developments show the significance of contributions of biogenic CO2 emissions during the Xxxxxx Xxxxx Observatorytime they stay in the atmosphere. The identification goal of this article is efficiently performed to develop a global, spatially explicit method to quantify the potential impact on human health and terrestrial ecosystems of biogenic carbon emissions coming from forest wood extraction for neutrinos biofuel production. For this purpose, changes in aboveground carbon stock (DCforest) due to an increase in wood extrac- tion via changes in rotation time are simulated worldwide with a 0.5° 9 0.5° grid resolution. Our results show that both impacts and benefits can be obtained. When the extraction increase is reached by creating a longer rotation time, new growth is allowed resulting in carbon benefits. In a case study, we assessed the life cycle impacts of all flavors interacting heat production via wood to determine the significance of including biogenic CO2 emissions due to changes in forest management. Impacts of biogenic CO2 dominate the total climate change impacts from a wood stove. Depending on the wood source country, climate change impacts due to heat production from wood either have an important share in the atmosphere at overall impacts on human health and terrestrial ecosystems, or allow for a large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–additional CO2 sink.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. 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University Library Radboud University ournal the concept of Cosmology the state in political philosophy Department of Public Administration and Astroparticle Physics JCAP10(2019)022 Political Science, Institute for Management Research, Radboud University Nijmegen, PO Box 9108, 6500 HK Nijmegen, the Netherlands E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19x.xxxxxxxxxx@xx.xx.xx *Corresponding editor. doi:10.1057/eps.2010.56 Abstract In a lecture given in 1991, 2019 Accepted September 5while working on the never finished third volume of his series on theories of justice, 2019 Published October 8Xxxxx Xxxxx gave a rare glimpse into the ideas with which he was wrestling – twenty years ahead of present-day political theorists. What is the role of the state, 2019 Abstracthow are we to conceptualize it, in a world if globalization, and against the background of a legitimate appeal for international distributive justice? Keywords international justice; social justice; sovereignty; state T EDITOR’S NOTE 92 european political science: 10 2011 at his talk into an article. Neutrinos Moreover, the notes he used were already part of the book manuscript he was working on at the time – the never completed third volume of his treatise on social justice. Xxxxx felt that turning the lecture into an article would add little to, and only distract from his work on, the book – but he did not mind publication in the form I proposed: authorized lecture notes dis- playing one of the best political philoso- phers of our days struggling to perfect and further develop his ideas though debate with energies above 1017 eV are detectable his critics. The text was offered for publication in the journal of the Dutch Political Science Association in the autumn of 1991, but its editors neither appreciated the format, nor were they (92 – 102) & 2011 European Consortium for Political Research. 1680-4333/11 xxx.xxxxxxxx-xxxxxxxx.xxx/xxx/ impressed by the novelty of what Xxxxx had to offer. It was rediscovered in 2009 in the process of converting files, created with now defunct word processing software, to a more current format. I have added nothing to the original text, except a couple of references to Xxxxx Xxxxx’x own (later) work. Although little of what Xxxxx had to say is really surprising, from the point of view of 2009, the text does offer a rare glimpse into the ideas with which Theories of Justice: Volume III might have begun, and for the biographer it shows the very first signs of his growing impatience with academic political philosophy. The 1991 lecture was prepared while he was working on the final draft of his second volume in the Theories of Justice series – or so he thought at the time. However, Xxxxx Xxxxx always refused to publish any text he was not deeply satisfied with; hence, Justice as Impar- tiality did not appear until 1995. Volume III – which, as Xxxxx announced in 1991, would discuss international justice – was never finished. Moreover, he soon changed his plans and intended to devote Volume III to the institutions of justice (cf. Xxxxxxx, 2009). Instead, after a period during which Xxxxx wrote about environmental and intergenerational justice, he aban- doned purely ‘academic’ political theory completely in favour of more involved writing like Culture and Equality (2002) and Why Social Justice Matters (2005). As Xxxxx Xxxxxxx (2009) noted, Xxxxx left behind the manuscript of a book on international social justice, all but finished in 1980: Rich Countries and Poor Coun- tries. Had it been published then, the book would have set him on a collision course with Xxxxxxx Xxxxx (1979) and Xxxxxx Xxxxx (1989), the first major thinkers to apply Xxxx Xxxxx’ theory of social justice on a global scale (the oracle himself remained silent on global justice until 1997; cf. Xxxxx, 1999). While Xxxxx certainly agreed with the Surface Detec- tor Array cosmopolitans on the existence of global distributive ‘y American academics in general attach far too much importance to the state and far too easily assume that only a world injustice and of moral obligations towards the world’s poor, the 1991 lecture illustrates that, and why he had little faith in global redistributive institutions or powers. Justice requires a commitment, a sense of belonging, to a cooperative venture, and it requires strong institutions to effectively implement redistribution, neither of which a global society or world state can offer in any foreseeable future. A position like this might be taken as support for Xxxxx’ later rejection of global justice; for Xxxxx (1999), the reciprocity, broadness, intensity and duration of the Xxxxxx ties that make a people a people justify limiting social justice to within the bor- ders of its state, and justify the rejection of global redistribution. Yet the most important message in Xxxxx’x 1991 lec- ture is that Xxxxx Observatoryand – as we can sense in Xxxxx’x reply to a comment by Xxxxxxx Xxxxxxxx – American academics in gen- eral attaches far too much importance to the state and far too easily assumes that only a world state can be an alternative for the classical nation-state. Xxxxx calls for a far more flexible understanding of structures of social cooperation, reflecting a political reality in which state authority ‘leaks away’ to sub- and supranational institutions, and in which peoples, socie- ties and cooperative ventures are not necessarily identical (cf. also Wissenburg, 2007). In this respect, Xxxxx was at least a decade ahead of, and may still inspire, current academic debates on the right to partial or total secession, on the justification of borders per se, and about the (at least contractual) justification of governance and institutions of governance. XXXXX XXXXX’X LECTURE Undoubtedly, Xxxx Xxxxx’ A Theory of Justice (1971) has been responsible for an upsurge in the production of political philosophical literature. Yet little of what has been written since – including my own work – concerns the concept of the state. Modern political philosophy takes the state and its boundaries as a given, in sharp contrast to classic contract theor- ists like Xxxxxx, Xxxxx, and Xxxxxxxx. Xxxxx himself is a good example: his theory is built on the assumption of a certain kind of society, characterized as a group of people living in a state, with a common sense of justice, and rules to which they agree and generally adhere. A society is, furthermore, supposed to know no immigration or emigration, to be economically self-sufficient, and to have no external obligations of any kind. In short, Xxxxx’ view of society is not xxx- xxxxx for this century; an organization like the UN does not fit into his theory. Within this framework, Xxxxx develops a social-democratic theory of the rights of citizens. His explicit aim is the reconcilia- tion of liberty and equality by means of his two principles. Liberty in these principles is represented by civil liberties and the free- dom to follow one’s preferences; equality is the basic principle of distribution. How- ever, the theory has a hidden third leg – efficiency. Xxxxx turns the Pareto-principle of rationality or efficiency into a principle of justice. He allows deviations from equality in those cases where an unequal distribution would make someone better off than she was before, without making anyone else worse off. From these possi- ble Pareto-optimal distributions, Xxxxx then selects the most equal distribution, the one that makes the worst-off in society best off – the so-called maximin-rule. Now Xxxxx is important for two reasons. Firstly, he is politically important. Ever since the publication of his book, it seems clear to us that if a moderately redistribu- tive welfare state – like ours – can be defended, then Xxxxx’ theory would be best suited. Secondly, he is intellectually important as he has set the agenda for political philosophy, leaving open numer- ous lines for criticism and revision. Let me illustrate four possible types of move towards Rawls. Firstly, Xxxxx’ argu- ments can be criticized, especially his Original Position and the derivation of his principles from this version of the state of nature. There are other conceivable ori- ginal positions, and I think mine is one of the more interesting (cf. Xxxxx, 1989). Secondly, there are internal problems of consistency in his theory. His principle of distributive justice – the ‘difference principle’ – for instance combines two political theories in one: Xxxxxx’s, which is welfare-based, and his own, which is resource-based. The identification is efficiently performed for neutrinos effect of all flavors interacting applying this principle might be that someone gets paid more (resources) as an incentive to work harder in the atmosphere at large zenith anglesinterest of society, but in fact works less hard, and therefore has more welfare. The difference principle is intuitively appealing, but cannot be taken seriously as it stands now. the social security of a welfare state. I now switch to autobiography for a short personal statement. I feel com- mitted to both the political and the intellectual programme of Xxxxx: I think the Western European arrangements of societies are better than any existing alternative, and I think that changes in these arrangements must be defended from within the existing framework. The most fruitful approach to political theory is contractual, that is, justification of theories by agreement under ideal con- ditions. Xxxxxxx Xxxxx’ Political Equality (1990) is an excellent example of this approach, as well is my own three-volume treatise on social justice1 – though I fear it will turn out in the same way as for Earth-skimming τ neutrinos with nearly tangential trajectories relative my Political Argument (Xxxxx, 1968), which seems to have been the Earthlast contribution to linguistic philosophy. No neutrino candidates were found My book on social justice may be seen as the end of the line, while the philosophical debate is moving into new territory. I do not think that I am saying the last word on the subject, but perhaps our energy can be spent in ∼ 14.7 years better ways. Now why do I say this? Because build- ing theories of data taken up to 31 August 2018. This leads to restrictive upper bounds on their fluxthis kind is more costly than beneficial. The 90% C.L. singleadvantages are real; there is now a well-flavor limit to worked out tradition for analysing states – but the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum problem is that the conceptual net catches too little reality. Compare Xxxxx’ assumptions about the state: the facts are that there are many political decisions taken outside the state’s borders – for example in the energy range 1.0 × 1017 eV–the
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal BRAIN IMPAIRMENT VOLUME 18 NUMBER 1 MARCH pp. 138–173 c Australasian Society for the Study of Cosmology Brain Impairment 2016 doi:10.1017/XxXxx.2016.31 Social Cognitive Interventions in Neuropsychiatric Patients: A Meta-Analysis Xxxx´e X. Xxxxxxx,1,2,3 Xxxxx Xxxxxxxxx¨ hle,1,2 Xxx X.X. Egger1,2,3,4 and Astroparticle Physics JCAP10(2019)022 EXxx P.C. Kessels2,4,5 = = = = Social cognitive deficits are common in neuropsychiatric disorders. Given the prox- imity of social cognition (SC) to everyday functioning, many intervention studies (including targeted, comprehensive, and broad-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatorybased approaches) have focussed on SC. The identification is efficiently performed aim of this paper was to quantitatively meta-analyse the efficacy of SC interventions in adult neuropsychiatric patients. Databases Pubmed, PsycINFO, Web of Knowledge, and Embase were searched for neutrinos controlled SC intervention studies published between 01-01-2003 and 01-01-2016. Forty-one studies, com- prising 1,508 patients with schizophrenia, autism spectrum disorders, or acquired brain injury were included. Outcome measures evaluated emotion perception (EP), social perception (SP), Theory of all flavors interacting Mind (XxX), and social functioning (SF). The meta-analyses showed that interventions were effective in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earthimproving SC (Xxxxx’x d .71). No neutrino candidates Interventions targeting one specific SC function were found to be most effective (d .89), followed by broad-based interventions, targeting non-SC do- mains in ∼ 14.7 years addition to SC (d .65), and comprehensive interventions, that target multiple SC processes (d .61). Targeted interventions were especially effective in improving EP and XxX. Comprehensive interventions were able to ameliorate EP, ToM, and SF. Broad-based interventions were especially effective in improving SF, but also showed effects on EP and XxX. Keywords: Social cognition, training, treatment, psychotherapy, neuropsychiatry, emotion perception, social perception, theory of data taken up mind, social functioning, systematic review Introduction Social cognitive deficits are common in a va- riety of psychiatric and neurological disorders. Given the proximity of social cognition (SC) to 31 August 2018. This leads to restrictive upper bounds everyday functioning, many intervention studies have focussed on their fluximproving SC in these popula- tions. The 90% C.L. singleaim of this paper is to quantitatively meta-flavor limit analyse the efficacy of these interventions in adult neuropsychiatric patients. SC is considered to be a cognitive domain that includes the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–mental processes underlying social + +
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with JCAP04(2012)040 A search for anisotropy in the Surface Detec- tor Array arrival directions of ultra high energy cosmic rays recorded at the Xxxxxx Xxxxx Observatory. Observatory The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for EarthXxxxxx Xxxxx collaboration X. Xxxxx,75 X. Xxxxxxxx,58 X. Xxxxxx,110 X.X. Xxx,94 I.F.M. Albuquerque,20 X. Xxxxxx,34 X. Xxxxxxxxx,1 X. Xxxxx,98 X. Xxxxxxx,100 X. Xxxxxx,13,9 X. Xxxxxxx Xxxxxxxx,68 X. Xxxxxxx-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Xxx˜iz,85 X. Xxxxxxxx,51 X. Xxxxxxx,69 X. Xxxxxxxxxxx,111 X. Xxxxxxxx,75 X. Xxxxˇxx’c,28 C. Aramo,51
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University Journal of Cosmology and Astroparticle Physics Multi-resolution anisotropy studies of ultrahigh- Observatory To cite this article: X. Xxx et al JCAP06(2017)026 View the article online for updates and enhancements. You may also like - ATLAS data quality operations and performance for 2015–2018 data-taking energy cosmic rays detected at the Xxxxxx Xxxxx X. Xxx, X. Xxxxxx, X.X. Xxxxxx et al. - Impact of atmospheric effects on the energy reconstruction of air showers observed by the surface detectors of the Xxxxxx Xxxxx Observatory
X. Xxx, X. Xxxxx, X. Xxxxxxxx et al. - Search for photons with energies above 1018 eV using the hybrid detector of the
X. Xxx, X. Xxxxx, X. Xxxxxxxx et al. ournal of Cosmology and Astroparticle Physics JCAP10(2019)022 JCAP06(2017)026 Multi-resolution anisotropy studies of ultrahigh-energy cosmic rays detected at the Xxxxxx Xxxxx Observatory The Xxxxxx Xxxxx collaboration E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received November 25, 2016 Revised March 17, 2017 Accepted May 26, 2017 Published June 1913, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array of the Xxxxxx Xxxxx Observatory. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–2017 −3
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal & Oligosaccharides Advances in Stereoselective 1,2-cis Glycosylation using C-2 Auxiliaries Xxxx X. Xxxxxxx and Xxxxxx X. Xxxxxx*[a] Chem. Eur. J. 2017, 23, 17637 – 17653 17637 T 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Abstract: The control of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array stereoselectivity in a glycosylation reaction remains one of the Xxxxxx Xxxxx Observatorymost challenging aspects of oli- gosaccharide synthesis. Especially the synthesis of 1,2-cis-gly- cosides is challenging and generally applicable methodology to prepare this linkage is needed to standardize oligosac- charide synthesis. This review highlights the recent develop- ment of an elegant strategy employing a C-2 auxiliary to control the anomeric stereoselectivity in glycosylations. The identification is efficiently performed for neutrinos of all flavors interacting in the atmosphere at large zenith anglesvarious auxiliaries developed to date, their compatibility with protecting groups and monosaccharide types as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative to mechanistic aspects are summarized. Furthermore, the Earth. No neutrino candidates were found appli- cation, advantages and limitations of C-2 auxiliaries in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–oligo- saccharide synthesis are discussed.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Xxxxx Xxxxx(✉) and Xxxx Xxxx {xxxxxx,xxxxxxxx}@xx.xx.xx Blockchain technology has received a huge interest ever since its inception in the cryptocurrency Bitcoin [22]. Indeed, on a global scale companies and gov- ernments [27] are looking for applications of Cosmology this technology [13]. Cryptocur- rencies, in particular Bitcoin, are the best-known and Astroparticle Physics JCAP10(2019)022 Emost successful scenario where blockchain technology has been adopted, but many other applications of blockchain have been proposed, such as supply chain management [28], identity management [15], and smart energy grids [29]. However, the justification for using a blockchain in many of these scenarios is unclear. Indeed, many papers have argued that using a blockchain is not the best – or not even a good – solution for particular scenarios [17]. This has led to the proposal of methodologies for deciding if blockchain is an appropriate solution for a given scenario, from a technical point of view [25, 39]. However, non-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV technical drivers are detectable with the Surface Detec- tor Array not typically discussed in most of the Xxxxxx Xxxxx Observatorycomputer science literature. The identification is efficiently performed In this paper we try to look beyond this technical view, and we also consider the non-technical drivers behind the choice for neutrinos of all flavors interacting blockchain in the atmosphere at large zenith angles, as well as for Earthreal-skimming τ neutrinos with nearly tangential trajectories relative to the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–world scenarios.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Astron. Nachr. / AN 328, No. 7, 593–624(2007) / DOI 10.1002/asna.200740001 Multi-Messenger Cosmic Particles 55 contributions Chairperson: Xxxxxxxx Xxxxxx, Karlsruhe Splinter Meeting A A 54 GEORG ZWETTLER1 , DIETER BREITSCHWERDT1 1Institut für Astronomie der Universität Wien, Xxxxxxxxxxxxxxxxxx 00, 0000 Xxxx, Xxxxxxx xxxxxxxx@xxxxx.xxxxxx.xx.xx, xxxxxxxxxxxxx@xxxxx.xxxxxx.xx.xx Galactic Cosmic Rays are observed over a wide range of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mail: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable with the Surface Detec- tor Array from ∼ 109 − 1021eV. The energy spectrum of the particle flux is a powerlaw with an overall spectral index of −2.7 with a steepening at around 1015eV (knee) and a flattening at ∼ 1018eV (ankle). Diffusive shock acceleration quite naturally leads to a powerlaw with appropriate spectral index with an energy limit in SNRs at 1015eV, depending on the charge of the particle. Xxxx and Xxxxx (2001, MNRAS, 321, 433), for example, reach higher energies by amplifying the upstream magnetic fields of SNRs non-linearly, whereas Xxxx and Xxxxxxxxxxxx (2004, A&A, 417, 807) use ’Slipping Interaction Regions’ generated by weak spiral density shocks in galactic winds to circumvent the limitations of SNRs. According to CR clock measurements, energetic particles escape from the galaxy in a few times 107yrs. We therefore consider shock waves in galactic winds as a possible source of energetic particles between the knee and the ankle. If these shocks are strong they can reaccelerate these galactic cosmic rays to significantly higher energies. We discuss a model in which galactic winds are described in a flux tube geometry (Xxxxxxxxxxxxx et al. , 1991, A&A, 245, 79) and reformulate the Fokker-Xxxxxx Xxxxx ObservatoryEquation in these coordinates. Approximate solutions for the particle distribution function, based on singular perturbation analysis, will be discussed. We find that it is possible to reaccelerate particles to energies up to 1018eV. A 71 XXXXX FALCKE1,2 FOR THE LOFAR COSMIC XXX XXX SCIENCE PROJECT 1Dept. of Astrophysics, Institute for Mathematics, Astrophysics and Particle Physics, Radboud University, Nij- xxxxx, The identification is efficiently performed for neutrinos of all flavors interacting Netherlands 2ASTRON, Dwingeloo, The Netherlands It has been realized in the atmosphere at large zenith angleslast couple of years that the new generation of digital radio telescopes, such as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative LOFAR, offers a unique opportunity to directly observe the Earth. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux impacts of ultra-high-high energy neutrinos with an Eν−2 spectrum cosmic rays and neutrinos. Brief radio flashes are produced when these particles hit the earth atmosphere or a solid surface such as the ice sheet in Antartica or the lunar regolith. In the former case the emission process is due to geosychrotron emission produced through interaction of air shower electron/positron pairs gyrating in the earth magnetic field while in the latter case a Cerenkov-like process is expected and observed in accelerator experiments. Radio emission of ultra-high energy range 1.0 × 1017 eV–cosmic particles offers a number of interesting advantages. Since radio waves suffer no attenuation, radio measurements allow the detection of very distant or highly inclined showers, can be used day and night, and provide a bolometric measure of the leptonic shower component. Significant advances in this field have recently achieved with our XXXXX (LOFAR Prototype Station) experiment which has been installed at the Forschungs- zentrum Karlsruhe in Germany next to the cosmic ray detector array ”KASCADE Grande”. The experiment has detected and imaged the radio emission from cosmic rays, confirmed the geosynchrotron effect for extensive air showers, and found an excellent correlation between radio pulse strength and primary particle energy. Future steps will be the installation of radio antennas at the AUGER experiment to measure the composition of ultra- high energy cosmic rays and the usage of the LOFAR radio telescope as a cosmic ray detector. Here an intriguing additional application is the search for low-frequency radio emission from neutrinos and cosmic rays hitting the moon. Simulations indicate that particle events above 1021 eV can be detected from the ground which promises the best detection limits for particles beyond the so-called GZK limit and allows one to go significantly beyond current ground-based detector arrays. A pathfinder experiment with the Westerbork Synthesis Radio Telescope is currently under way and first experiments with actual LOFAR hardware will commence soon.
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal of Cosmology European Societies, Vol. 16, No. 4, 594–614, xxxx://xx.xxx.xxx/ 10.1080/14616696. CHANGING CULTURE, STABLE STRUCTURE Segmented pluralism on the Dutch airwaves Xxxxx X. Xxxxx and Astroparticle Physics JCAP10(2019)022 E-mailXx X. X. Xxxxxxx Downloaded by [Radboud Universiteit Nijmegen] at 02:43 25 April 2015 Radboud University Nijmegen, Nijmegen, The Netherlands ABSTRACT: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable In this contribution we deal with the Surface Detec- tor Array contradiction between changing culture and stable structure, i.e., the phenomenon that a social structure that developed to accommodate a certain culture may remain stable over a long period of time, even when that culture changes. We do so for the case of the Xxxxxx Xxxxx ObservatoryDutch public broadcasting system, that was designed in the 1920s to fit with the segmented pluralism of Dutch society, in which a number of religiously and ideologically different groups had to peacefully co-exist. In the mid-1960s, Dutch society started to change rapidly and segmented pluralism started to wane. The identification is efficiently performed public broadcasting system, however, hardly changed until today. First we explain how structure and culture initially matched and how the concept of path dependency can explain how over time culture and structure can grow apart. Then, with data of six national surveys between 1979 and 2005, we explore the possible cultural grounds for neutrinos the fact that the segmented public broadcasting system has outlived the segmented pluralism of all flavors interacting in the atmosphere at large zenith angles, as well as for Earth-skimming τ neutrinos with nearly tangential trajectories relative Dutch society that it was originally designed to the Earthmatch. No neutrino candidates were found in ∼ 14.7 years of data taken up to 31 August 2018. This leads to restrictive upper bounds on their flux. The 90% C.L. single-flavor limit to the diffuse flux of ultra-high-energy neutrinos with an Eν−2 spectrum in the energy range 1.0 × 1017 eV–Key words: public broadcasting; segmented pluralism; social structure; culture; correspondence analysis; longitudinal analysis
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End User Agreement. This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act. This article entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. Research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act, are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the University Library know, stating your reasons. In case of a legitimate complaint, the University Library will, as a precaution, make the material inaccessible and/or remove it from the website. Please contact the University Library through email: xxxxxxxxx@xxx.xx.xx. You will be contacted as soon as possible. University Library Radboud University ournal Understanding “Failed” Markets: Conflicting Logics and Dissonance in Attempts to Price the Priceless Child Xxxxxxx Xxxxxxxxx Xxxx Xxxxxx Xxxxxxx Xxxxxxxxx Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) To cite this document: Xxxxxxx Xxxxxxxxx Xxxx Xxxxxx Xxxxxxx Xxxxxxxxx . "Understanding “Failed” Markets: Conflicting Logics and Dissonance in Attempts to Price the Priceless Child" In How Institutions Matter! Published online: 22 Dec 2016; 37-68. Permanent link to this document: Downloaded on: 01 March 2017, At: 05:07 (PT) References: this document contains references to 0 other documents. To copy this document: xxxxxxxxxxx@xxxxxxxxxxxxxx.xxx The fulltext of Cosmology and Astroparticle Physics JCAP10(2019)022 E-mailthis document has been downloaded 40 times since 2016* (2016),"Institutional Maintenance through Business Collective Action: auger xxxxxxxxxxxxx@xxxx.xxx Received June 19, 2019 Accepted September 5, 2019 Published October 8, 2019 Abstract. Neutrinos with energies above 1017 eV are detectable The Alcohol Industry’s Engagement with the Surface Detec- tor Array Issue of Alcohol-Related Harm", Research in the Xxxxxx Xxxxx ObservatorySociology of Organizations, Vol. 48B pp. 101-143 xxxx://xx.xxx.xxx/10.1108/ S0733-558X201600048B006 (2016),"How Institutional Logics Matter: A Bottom-Up Exploration", Research in the Sociology of Organizations, Vol. 48A pp. 137-155 xxxx://xx.xxx.xxx/10.1108/ S0733-558X201600048A005 Access to this document was granted through an Emerald subscription provided by emerald-srm:304742 [] If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit xxx.xxxxxxxxxxxxxx.xxx/xxxxxxx for more information. Emerald is a global publisher linking research and practice to the benefit of society. The identification is efficiently performed for neutrinos company manages a portfolio of all flavors interacting in the atmosphere at large zenith anglesmore than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Xxxxxxx and the LOCKSS initiative for Earthdigital archive preservation. *Related content and download information correct at time of download. Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) UNDERSTANDING “FAILED” MARKETS: CONFLICTING LOGICS AND DISSONANCE IN ATTEMPTS TO PRICE THE PRICELESS CHILD Xxxxxxx Xxxxxxxxx, Xxxx Xxxxxx and Xxxxxxx Xxxxxxxxx How Institutions Matter! Research in the Sociology of Organizations, Volume 48B, 37—68 Copyright Ⓒ 2017 by Emerald Group Publishing Limited All rights of reproduction in any form reserved ISSN: 0733-skimming τ neutrinos with nearly tangential trajectories relative 558X/doi:10.1108/S0733-558X201600048 B002 Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) Keywords: Cognitive dissonance; institutional logics; marketization; institutional change; failure; childcare
1). These wider trends are often linked to the Earthascendance of neo-liberal thought (Xxxxxxxx & Xxxxxxxx, 2001) rooted in the Chicago School of Economics which aggressively suggested that all arenas of social and eco- nomic life could be efficiently organized as markets (Xxxxxx, 1976), and successfully advocated market-embracing social policies. No neutrino candidates were found in ∼ 14.7 years In turn, policy- makers became influenced by conservative think tanks such as the American Enterprise Institute as well as major international NGOs and institutions such as the World Bank and IMF that promoted market- based solutions. However, despite the seeming hegemony of data taken up market-based policies, research has shown that markets are complex social structures that can be extraordinarily difficult to 31 August 2018construct (Xxxxxxxxx, 2001; Xxxxxxxx, 1990). This leads has been vividly demonstrated in macro-societal research on transitions from Socialism to restrictive upper bounds on Capitalism (Xxxx, Szele´nyi, & Xxxxxxxx, 1998; Xxxxxxx, 1999; Xxxxx, 1992). Yet, our understanding of market construction remains limited, especially with regard to how market creation efforts can go awry. While markets have seemingly taken over the world, it would be especially useful for us to understand the conditions under which they fail to take hold. We argue that societal institutions and institutionalized practices in organizations matter in shaping markets, or in our case, how they constrain neo-liberal attempts to privatize public sectors, often under the guise of the so-called new public management (Xxxxx & Xxxxxxxxxxxx, 2006). Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) Given that the successful creation and functioning of markets requires shared belief systems that enable producers and consumers to understand the nature and quality of what is being exchanged, situations of institu- tional complexity, where alternative institutional logics offer competing behavioral prescriptions (Xxxxxxxxx, Xxxxxxx, Xxxxxx, Xxxxxxxxx, & Xxxxxxxxx, 2011; Xxxxxxxx, Xxxxxx, & Xxxxxxxxx, 2012) can undermine the creation of such shared beliefs around markets. For instance, the remaking of an existing field animated by social welfare or religious logics into a market may meet with resistance by dominant incumbents (Xxxxxxxxx, 1996). That is, in situations where incumbents feel threatened by efforts to alter dominant logics, established actors may counter-mobilize to protect their fluxjurisdictions and established routines (Xxxxx, Xxxxxx, & XxXxxxxx, 2008). The 90% C.L. singleXxxxxxx and Xxxxxxxxx (2007) showed how banking professionals sought to maintain their professionally oriented community logic that was under assault by large, outsider banks promulgating a corporate-flavor limit oriented market logic, by creating a variety of new community banks. We believe that more needs to be done to conceptually understand how the particular contexts of different fields may make them more or less prone to the diffuse flux creation of ultramarkets. For instance, we believe that resistance to market logics may be more likely to be observed and effective under condi- tions where the field experiencing a threatening change is relatively homo- geneous and dominated by a single logic that underpins core incumbents. Under conditions of institutional complexity (Xxxxxxxxx et al., 2011), where fields are informed by multiple conflicting logics, and fragmented with a variety of organizations with different values and beliefs, resistant collective action may be more difficult to mobilize in response to efforts to create a market. However, pockets of resistance may still occur in this latter situation if some organizations interpret institutional change as a threat to their core identities and values. But whether and how such pockets of resis- tance can lead to halting market creation remains an important puzzle. To aid in this broader theory-high-energy neutrinos building effort, we illustrate our arguments with an Eν−2 spectrum attempt by the Dutch state to marketize childcare organizations by creating a childcare market (see also Xxxxxxxxxxx, Xxxxxxxxx, Xxxxx, & Xxxxxxx, 2015). We probe how a field comprised of multiple logics enabled organizations to variously resist adopting and implementing market logic practices. We document that even though the heterogeneity among child- care managers and their logics inhibited organized collective resistance, marketization efforts never took root, and have even been rolled back. We argue that underlying this resistance and failed market creation were strong institutionalized beliefs about childcare and a considerable amount of cog- nitive dissonance (Xxxxxxxxx, 1957) that cumulated into profound ambiva- lence at the field level, which constrained the privatization efforts of the government. Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) In the next section, we discuss how institutional complexity can stimu- late variegated responses, motivating our empirical illustration. We then provide an analytical narrative that tracks the effort to marketize Dutch childcare. Following the presentation of our illustrative case, we provide a process model of resistance under conditions of institutional complexity, and discuss its implications for future theorizing on institutional change. — While the market logic has become increasingly pervasive, fields are typi- cally characterized by multiple institutional logics that fuel the emergence of new practices as actors invoke, blend, or fuse logics to solve problems (Xxxxxxxxx et al., 2011; XxXxxxxxx & Xxxxxx, 2013; Xxxxxx, 2010). Institutional logics define the ends and shape the means by which interests are determined and pursued and provide the glue that links action and institutional effects in organizational fields arenas where actors “compete over the energy range 1.0 × 1017 eV–definition of issues and the form of institutions that will guide organizational behavior” (Xxxxxxx, 1999, p. 352). While Xxxxxxxxx and Xxxxxx (1991) identified five societal-level logics, capitalism, family, the bureaucratic state, democracy, and religion, scholars later identified other categories, notably corporate, professional, and more recently, community logics (Xxxxxxxx, 2004; Xxxxxxxx et al., 2012). Many fields and organiza- tions are by their very nature “an incarnation or embodiment of multiple logics” (Xxxxxx & Xxxxx, 2008, p. 244). For instance, healthcare is shaped by the logics of the market, the state, and professional medical care (Xxxxx, 2004) as is the field of pharmacy (Xxxxxxxx & Xxxx, 2011). Organizations in pluralistic fields operate across institutional spheres subject to “incompa- tible prescriptions from multiple institutional logics” (Xxxxxxxxx et al., 2011, p. 317). While earlier work often portrayed multiple institutional logics as starting or endpoints of change where subordinate, secondary or “minor- ity” logics may disrupt dominant logics (Xxxxxx & Xxxxxxx, 2012; Downloaded by RADBOUD UNIVERSITY NIJMEGEN At 05:07 01 March 2017 (PT) Xxxxxxxxx, 2001, 2007; Xxx, Xxxxx, & Xxxxxx, 2003; Xxxxxxxx, 2002), more recent work has shown that logic multiplicity and institutional com- plexity may persist and xxxxxx (Xxxxxxxx & Xxxx, 2011; Xxxxxxxxx et al., 2011; Xxxxxx, 2010; Xxxxx, Xxxxxxxxxxxx, Xxxxx, & Xxxx, 2015). Competing prescriptions may co-exist and require organizations to con- tinuously manage “constellations” of logics, both dominant and subordi- nate (Xxxxxx & Xxxxxxx, 2012), as well as cooperative and competing (Xxxxxxxx & Xxxx, 2011; Xxx & Xxxxxxxxx, 2015). While often driven by a dominant logic, organizations may also borrow and experiment with other socially available logics and practices grounded in these logics to solve local problems (Xxxxxx, 2012; Xxxxxxxxxx, 2007). But how do organizations navigate through conflicting institutional pressures in pluralistic fields where multiple logics guide behavior?
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